ID W1TQF1_9ACTO Unreviewed; 324 AA.
AC W1TQF1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Malate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Q618_VCMC00001G1433 {ECO:0000313|EMBL:ETI83852.1};
OS Varibaculum cambriense DORA_20.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Varibaculum.
OX NCBI_TaxID=1403948 {ECO:0000313|EMBL:ETI83852.1, ECO:0000313|Proteomes:UP000018843};
RN [1] {ECO:0000313|EMBL:ETI83852.1, ECO:0000313|Proteomes:UP000018843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DORA_20 {ECO:0000313|Proteomes:UP000018843};
RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA Banfield J.F.;
RT "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT community with otherwise low bacterial novelty that shifts toward anaerobic
RT metabolism during the third week of life.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETI83852.1}.
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DR EMBL; AZMI01000001; ETI83852.1; -; Genomic_DNA.
DR STRING; 184870.HMPREF1862_00840; -.
DR eggNOG; COG0039; Bacteria.
DR Proteomes; UP000018843; Unassembled WGS sequence.
DR GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF0; MALATE DEHYDROGENASE 2, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003369};
KW Reference proteome {ECO:0000313|Proteomes:UP000018843}.
FT DOMAIN 11..151
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 162..216
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT REGION 301..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 35152 MW; 7D80DBD412E47376 CRC64;
MAECCCKKPV TVTVTGAAGN IGYALLFRIA SGAMLGPDQP VKLNLLEIPQ AVKAAEGTAM
ELNDSAFPLL AGVDIYDDPN QAFAGCSYGL LVGARPRSKG MERADLLAAN GGIFGPQGKA
INDNAADDIR VLVVGNPANT NAYIASKSAP DVPAERFTAM MRLDHNRAIS QLAEKTGAAV
KDIKKMIVWG NHSADQYPDL TFATVDGKPA PELVDEAWLD DYFVPTXXXX XXXXXXXXXX
XRCHYRGSGR FFGGFGGFGG YRPYAHLGSR YSRGRLVYFR RPLSRRIRSS RRPHLRYARN
LQGRTVPGSG RSRAPRKDQA AYRG
//
