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Database: UniProt
Entry: W1TZA2_9FIRM
LinkDB: W1TZA2_9FIRM
Original site: W1TZA2_9FIRM 
ID   W1TZA2_9FIRM            Unreviewed;       493 AA.
AC   W1TZA2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=Q612_NSC00279G0018 {ECO:0000313|EMBL:ETI86756.1};
OS   Negativicoccus succinicivorans DORA_17_25.
OC   Bacteria; Firmicutes; Negativicutes; Veillonellales; Veillonellaceae;
OC   Negativicoccus.
OX   NCBI_TaxID=1403945 {ECO:0000313|EMBL:ETI86756.1, ECO:0000313|Proteomes:UP000018840};
RN   [1] {ECO:0000313|EMBL:ETI86756.1, ECO:0000313|Proteomes:UP000018840}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DORA_17_25 {ECO:0000313|Proteomes:UP000018840};
RA   Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA   Banfield J.F.;
RT   "A Varibaculum cambriense genome reconstructed from a premature infant
RT   gut community with otherwise low bacterial novelty that shifts toward
RT   anaerobic metabolism during the third week of life.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747914}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETI86756.1}.
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DR   EMBL; AZMC01000279; ETI86756.1; -; Genomic_DNA.
DR   PATRIC; fig|1403945.3.peg.553; -.
DR   Proteomes; UP000018840; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018840};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018840}.
FT   DOMAIN      185    322       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      400    469       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     193    200       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   493 AA;  56014 MW;  1D65EC2E4D4F137E CRC64;
     MTDIFDFWET VLARLGERIS PEMLNWLMSH VLPLTLTEDT LTAQVSKPFL KIWLEQNLLS
     DLQATVNEVA ARPLTLQITL PQATDVPTSP LPSTNSTETS TLPEPPVPIF TRPTPSVEQT
     TLPIATSTAA TQDTQVAAVS ENERNFGKRS IPIDPSCTFD NFIVSNSNTL ARSAAFAVAQ
     QPAQYQNPLF IYGPSGLGKT HLMHAICNYV RAHTPEKKFL FLTSEDFTND FISALTQKGV
     EHNRAFREKY RSVDYLLIDD VQFFGKKDGT QLEFFHTFNE LLNSKKQIVM TCDRLPENME
     KVEQRLISRF RMGLVVEIQP PDFEIRSAYL QKKAAAADIS IPTEVVSFLA ENFTEDFREL
     GGVFNRIATL QSLSPEPITV EWAQQQLADI LPTERRIILN PDVIINEVAS FYKIRRDKLV
     GKTRPKNIVF PRQIAMFLCR EMLDLSFKEI AAAFNKNDHT TVMHAYDKIY KELQTNIKLQ
     EEMQQIRQFL TGG
//
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