ID   W1UA05_CLOBU            Unreviewed;      1750 AA.
AC   W1UA05;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Helicase HerA central domain-containing protein {ECO:0000259|Pfam:PF01935};
GN   ORFNames=Q607_CBUC00054G0057 {ECO:0000313|EMBL:ETI90597.1};
OS   Clostridium butyricum DORA_1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1403941 {ECO:0000313|EMBL:ETI90597.1, ECO:0000313|Proteomes:UP000018876};
RN   [1] {ECO:0000313|EMBL:ETI90597.1, ECO:0000313|Proteomes:UP000018876}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DORA_1 {ECO:0000313|Proteomes:UP000018876};
RA   Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA   Banfield J.F.;
RT   "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT   community with otherwise low bacterial novelty that shifts toward anaerobic
RT   metabolism during the third week of life.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETI90597.1}.
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DR   EMBL; AZLX01000054; ETI90597.1; -; Genomic_DNA.
DR   PATRIC; fig|1403941.3.peg.1243; -.
DR   Proteomes; UP000018876; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR017646; Dnd_assoc_2.
DR   InterPro; IPR002789; HerA_central.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03237; dnd_assoc_2; 1.
DR   PANTHER; PTHR42957; HELICASE MJ1565-RELATED; 1.
DR   PANTHER; PTHR42957:SF1; HELICASE MJ1565-RELATED; 1.
DR   Pfam; PF01935; DUF87; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
FT   DOMAIN          1393..1608
FT                   /note="Helicase HerA central"
FT                   /evidence="ECO:0000259|Pfam:PF01935"
FT   REGION          1287..1367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1287..1324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1333..1351
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1750 AA;  200298 MW;  C8A299941ED60BBD CRC64;
     MSDQFYSYLS DKIIEFFNMN PLSIGAKYNI QFEKQEQVLA LYDELKKNTL YKEYEYKDSK
     GNVKYTSYLL DFPNVKLIIS ATINGVQPDF LTRLRNMVGV EDGYKDKAIL FIHDTTLDSI
     MGGTESFSKE GMPFHIKSIE KDINRKLSDS NFSEVDKAII NLDIERKNKE LLGESISIFE
     YKDLLAIVNG TCIEKDQYKS FGLFYDSKLK DYTGKQLKNR IDENATNFNR VDEIHSYGNP
     EVQLEKYFDN KGVDKLKSEE WKDTDFKDVK KYIEDRISTP ILEYLGNTVD WDREEGASKV
     KSRIRNMIIF NERREETIDM ELPFDATLHK EFLSRVDGDA EVSTSGKKIK VTLKNCDGNA
     NFYKIVYKNE NTKFEFRIVV VTCNEKYLES IKTKFSVIYN KKYSYISINT NESSIVFNEF
     ASTINNYELT NNYEEVAISE DDRLILKISD NFDYENDSDL VKFKISIEGN KIPFGVIGTS
     EKIAPIEGLK VWKLKREKKC DFKFIGDNKL QHGTKEYFTR DEFRKNLQLE NQIIELEGMA
     FEDTSEGLDC VDLELNDDVK EAFENIVRYF KTSNKLPSLT YLNEDLKDLY ERFIKVYIRE
     LNKIEEKEYL TRKQKALFRI GTIKRVCEDK ELLFTPLNPL NIAYQLHIND TVKDEVLEDD
     IIKKFTSTYL LPYINVGEDR LYIPMEQNHS PEWKYYVDDK LPRYKSSRDF VSKLVNEKIT
     EFVDHFKYLF NMGNNAPIRI NLINTGDSKE ILQGIFKYYI KQLKSKKKEV LPIDLFIYSN
     KGITNAFEEV AFNDNIKDLK ELYDLDLNVS SMSEEDVLDL YREKVHFYSK KVDNGIEYAH
     ITFIEMSNNA KTIKSNMDDI PSGIILNGLI SGVPSVFSGD YYRTGFGTKY ANTETDLMTV
     SSKLNAVNAA INGEAFDSNS CTAISVANKN KATLDDIYNA SHWVTFIDPK VDLNFFKNDP
     DAKDLLIIHY SDQYTTAGGY DAITVTRKSG PYQKVIEEFL SKKGIENPKD YSSGVINMFN
     AVNGDWLLRL LSTKSHFPKE KISILSAIKL ALAKFKKDNV IWVPISLEEV LRVSGGAGLK
     QSEGFLSAKQ LGFDNSGATS DDILLIGIEN VYGNTYVHYY PIEVKIGDNP NWYVNKGIEQ
     AKTTKKIFNE ILLPKEGQEL TNTQKVYRNF LMQLVVTSAE KLNLYSVCNE ENWNSVIDSD
     LRRVLLNEEY IISNTFEESL GEAAVISFKD ENKNSDIRIE DNVMVLEMTE NDGIEFITKT
     VGEIREKVGT VDIKSIGVMG STDVQIDDSD AANGSQNNID DNTSSLNKNN GKEETQNDAV
     STYVSGVDNA EDIEADMSIK TDSDSGKEIT ESKSVADPGS EYEDSNVDTD RNMQILFGVN
     QKNHKEVYWC PNDTNKLMHT NTGIIGTMGT GKTQFTKSMV TQIHRESKYN VDGKNVGILI
     FDYKGDYNKS KQDFIEATDA KVFELYHLPF NPLSVVKAVN SKPMLPLHTA NGLKETIAKA
     FGLGIKQETL LRDLIMEAYE KRGIIKNKPD TWDNLAPTLK DVYDIYVSKE DLKEDSLYAA
     FSNLIDFEIF EPDCNETQSL FELIDGVTVI DLSGYDPGIQ NLVVAITLDL FYSQMQAYGH
     SKIDGNLRQL NKIVLVDEAD NFLSKNFSSL KKILKEGREF GVGTILSTQL LSHFSTGENE
     YANYILTWVV HNVADLNNKD VKYIFNTQSK GEEENIYSKI KSLNKHYSIV KMGDSDRAVF
     MKDKAFWELK
//