ID W1Y6V6_9ZZZZ Unreviewed; 595 AA.
AC W1Y6V6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=Q604_UNBC08883G0002 {ECO:0000313|EMBL:ETJ36869.1};
OS human gut metagenome.
OC unclassified sequences; metagenomes; organismal metagenomes.
OX NCBI_TaxID=408170 {ECO:0000313|EMBL:ETJ36869.1};
RN [1] {ECO:0000313|EMBL:ETJ36869.1}
RP NUCLEOTIDE SEQUENCE.
RA Brown C.T., Sharon I., Thomas B.C., Castelle C.J., Morowitz M.J.,
RA Banfield J.F.;
RT "A Varibaculum cambriense genome reconstructed from a premature infant gut
RT community with otherwise low bacterial novelty that shifts toward anaerobic
RT metabolism during the third week of life.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETJ36869.1}.
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DR EMBL; AZMM01008883; ETJ36869.1; -; Genomic_DNA.
DR AlphaFoldDB; W1Y6V6; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ETJ36869.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..150
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 166..475
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 595 AA; 68812 MW; A35B955BBBC8EA1F CRC64;
MNEFKRHQQT SINVQKQANL IWNVADILRG LYKPHEYGKV ILPMTVIKRL HDTLLKTRDE
VLKTSENTKS INDVMRERLL KNASGYSFYN TSLYTFETLL ADPANIESNF RAYLNGFSEN
MQDILNNFKF DVEITTMADN DALFYVIQEF NKADAYLGPD KMTSTDMGYV FEELVRKFSE
SYNEEAGAHF TSRDIIYLMT DLLLIEDKNT LFKEHVFKTV YDQTMGTSQM LSAMTERIHD
MNDTAEVATF GQELNPETYA IAKADTMIRG GEPENMALGS TLTNDHFEGF KFDYCISNPP
FGVDWKKDQK AVKSEHELGE LGRFGVGLPR ISDGQLLFQL NGLSKLKETG RMTIIHNGSA
LFSGNPGGGE SLIRQYVIEN DWLEGIIQLP NDLFYNTDIS TYIWIITKNK SPERQGKVQL
IDASNMYEKR RKNIGEKRVD ISEACREKIV QAYGEFDNKE YHFEDRTVES KILNNESFGF
TRVTIERPER NKNGDIVYKK NRNMRADTSL RDTEDIPLTE DINEYFKREI LKFIPDAWID
RKKDKVGYEI PFTKLFYKYI PPEPSETISE RIKQLEESIV KNFQVLSGKE VDTDE
//
