ID   W2ES63_9ACTN            Unreviewed;      1268 AA.
AC   W2ES63;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Protein kinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MPTA5024_18735 {ECO:0000313|EMBL:ETK34563.1};
OS   Microbispora sp. ATCC PTA-5024.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Microbispora.
OX   NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK34563.1, ECO:0000313|Proteomes:UP000018869};
RN   [1] {ECO:0000313|EMBL:ETK34563.1, ECO:0000313|Proteomes:UP000018869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK34563.1,
RC   ECO:0000313|Proteomes:UP000018869};
RX   PubMed=24459268;
RA   Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA   Stegmann E., Weber T.;
RT   "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT   Producing the Lantibiotic NAI-107.";
RL   Genome Announc. 2:e01198-13(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETK34563.1}.
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DR   EMBL; AWEV01000141; ETK34563.1; -; Genomic_DNA.
DR   RefSeq; WP_036325210.1; NZ_KI866523.1.
DR   AlphaFoldDB; W2ES63; -.
DR   STRING; 316330.MPTA5024_18735; -.
DR   PATRIC; fig|316330.3.peg.3618; -.
DR   HOGENOM; CLU_264167_0_0_11; -.
DR   OrthoDB; 9801841at2; -.
DR   Proteomes; UP000018869; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR011528; NERD.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   PANTHER; PTHR45832:SF24; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45832; SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED; 1.
DR   Pfam; PF08378; NERD; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR   PROSITE; PS50965; NERD; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018869}.
FT   DOMAIN          10..120
FT                   /note="NERD"
FT                   /evidence="ECO:0000259|PROSITE:PS50965"
FT   DOMAIN          196..454
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          473..720
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   1268 AA;  138540 MW;  AFCB1F445E133CF5 CRC64;
     MARLHVLSDW HGPGEEKTAR LLAAELPDDW DVIAGRQIPT HTDPVDLDLI VVGVNGIYVC
     EEKSWGPHVV AGEVAWYVNG EQRSDPVGQV AHAARVLAGR LRAKVGGWAA AQANLPRGVR
     PVTGHVVMSH SSIDLSGTGD LGEDKVVTLD AAAAMLTARD AALPDTMSAL RPKAMSYLLG
     LGPRNPTEAP KQIMQYKVAG LLGTDGNARV YAGSNPAGEL VFLHCVSVAN ATDRPAAELL
     AKREHDALTL LAKEDRTWHV RDWFDWEGYR VTPIVPDLSG ISLWKLSGDR PTPTDQENRI
     PPEIAKPVVH DAFAALTSVH AKEIMHRALR PRYIEITGDD RVRFRDFSRA RIPSVETIAP
     SLFDDHPSTP FRAPGATMEF FGTKDDVYSL ALSLVLWIHG DQDETPDHDQ ARERAAAYPE
     IGELMVRCLA PDYNDRPEAA EVASATAPDK ATALAIIEDA STPIAGQLVA DRYRLKHQLG
     EGAWAVTWLA TDEQLQGELR TLKYLKPDRV SWAQAFDEYQ NTDTLRSRFC ARVYDLRPEP
     EPGVLVQEYV PGTTLKELVT RETPTGDEFR RIALDVLAGL GDAHQQGLYH RDVSPANIIV
     RDDGAARLID FGLAAHVDDA HSAVGSPPFT APEVWERRAW SPAADLYAAA ASILHAMLGR
     YPYASTDLSG RRTLVPPSDE DRLRFGGAFL DALYQGVSYD PADRPQSAAD FARLLTEPST
     PSTTDKRKVN PTVAALRGLY RESGIGNAGN RGLDDVFAHD TYAKTRLDTE LLPAILNKKL
     DVVVLSGNPG DGKTSFLVKV GDALDARQAE KVHEDKAGWV KRLDGHTFVA VYDASESNGA
     LSSDEMLHRA LGLADGEDRS RCTVLIAAND GRVTQFFIDN YDLYPDVAAE LSKQRRGDAS
     PDSRVVLVDL KQRALAMPKK ADANGEAPDL AAAILDLFTT DFRWSDCADC VSRDVCPILR
     NATDLRAPAT KAAVMELVLT SHLRRRRRAT VRDVRSAFAW LITGDLSCDE VHSEHEADEN
     PATDARLLPG LTFAGASSDN LLQEWAELDP AGLPAPGAIR AARAREDLIP DLHTILDADI
     RRLKRALFLG QWGTVSGRLE VRSYRHLDEY LSAMDTPEQA LPRFLAGLSR VLGFVGYDGV
     RLALRDQMYD APAVRAIVVI KELDPTEFAL AASGARSRYI ESFPDLLVLR HSSGAELRIT
     LDTAELLLRA ADGEILGDLA SEAIRQEVTA FGNRLRREPA HAVRIIDGSG RSLRAKAIGG
     QIVREDAP
//