GenomeNet

Database: UniProt
Entry: W2ETI9_9ACTN
LinkDB: W2ETI9_9ACTN
Original site: W2ETI9_9ACTN 
ID   W2ETI9_9ACTN            Unreviewed;       517 AA.
AC   W2ETI9;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=MPTA5024_16290 {ECO:0000313|EMBL:ETK35048.1};
OS   Microbispora sp. ATCC PTA-5024.
OC   Bacteria; Actinobacteria; Streptosporangiales; Streptosporangiaceae;
OC   Microbispora.
OX   NCBI_TaxID=316330 {ECO:0000313|EMBL:ETK35048.1, ECO:0000313|Proteomes:UP000018869};
RN   [1] {ECO:0000313|EMBL:ETK35048.1, ECO:0000313|Proteomes:UP000018869}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC PTA-5024 {ECO:0000313|EMBL:ETK35048.1,
RC   ECO:0000313|Proteomes:UP000018869};
RX   PubMed=24459268;
RA   Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A.,
RA   Stegmann E., Weber T.;
RT   "Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024,
RT   Producing the Lantibiotic NAI-107.";
RL   Genome Announc. 2:e01198-13(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETK35048.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AWEV01000122; ETK35048.1; -; Genomic_DNA.
DR   RefSeq; WP_051458225.1; NZ_KI866523.1.
DR   EnsemblBacteria; ETK35048; ETK35048; MPTA5024_16290.
DR   PATRIC; fig|316330.3.peg.3155; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000018869; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018869};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018869}.
FT   DOMAIN      208    336       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      420    489       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     216    223       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   517 AA;  57137 MW;  5C7CBDD727BE7D85 CRC64;
     MEGVDLNAVW ARALGTLLDE GVSGQQRAFL QMTQPSGLIN DTILLAAPND FAKEVLEVRL
     RPLIVHALSQ ELGRPVRIAV MVDPSAASGQ AADQQRPSST DYPQHRPQAQ GFALGDEGPV
     QHDSGPVGGP QYPQHPQQPP RPGGYSPEPP PAPKPEPAQN RWDARGGRTG GEPARLNAKY
     TFETFVIGAS NRFAHAAAVA VAEAPAKAYN PLFIYGDSGL GKTHLLHAIG HYAQSLYDGA
     RVRYVSSEEF TNDFINSIRD HKADGFRSRY RAVDILLVDD IQFLEGKEQT QEEFFHTFNT
     LHNASKQIVI SSDRAPKQLV TLEDRLRNRF EWGLITDVQP PELETRIAIL RKKAIQEGLA
     APPDVLEYIA SRIATNIREL EGALIRVTAF ASLNRQSVDI QLAEIVLKDL ISEDASPEIT
     ISLIMSTTAE YFGVSLDDLC GGSRSRALVT ARQIAMYLAR ELTDLSLPKI GQQFGGRDHT
     TVMHAERKIR SLMAERRSMY NQVNELTTRI KQRARNT
//
DBGET integrated database retrieval system