ID W2H3C9_PHYPR Unreviewed; 3467 AA.
AC W2H3C9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETK89722.1};
GN ORFNames=L915_06365 {ECO:0000313|EMBL:ETK89722.1}, L916_06303
GN {ECO:0000313|EMBL:ETL43119.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETK89722.1};
RN [1] {ECO:0000313|EMBL:ETK89722.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ02B3 {ECO:0000313|EMBL:ETK89722.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ02B3.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETL43119.1, ECO:0000313|Proteomes:UP000053864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ05E6 {ECO:0000313|EMBL:ETL43119.1,
RC ECO:0000313|Proteomes:UP000053864};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ05E6.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI685657; ETK89722.1; -; Genomic_DNA.
DR EMBL; KI685657; ETK89723.1; -; Genomic_DNA.
DR EMBL; KI685657; ETK89724.1; -; Genomic_DNA.
DR EMBL; KI672218; ETL43119.1; -; Genomic_DNA.
DR EMBL; KI672218; ETL43120.1; -; Genomic_DNA.
DR EMBL; KI672218; ETL43121.1; -; Genomic_DNA.
DR EnsemblProtists; ETK89722; ETK89722; L915_06365.
DR EnsemblProtists; ETK89723; ETK89723; L915_06365.
DR EnsemblProtists; ETK89724; ETK89724; L915_06365.
DR EnsemblProtists; ETL43119; ETL43119; L916_06303.
DR EnsemblProtists; ETL43120; ETL43120; L916_06303.
DR EnsemblProtists; ETL43121; ETL43121; L916_06303.
DR VEuPathDB; FungiDB:PPTG_02596; -.
DR Proteomes; UP000053236; Unassembled WGS sequence.
DR Proteomes; UP000053864; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 3032..3369
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3435..3467
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3337..3375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3467 AA; 387004 MW; 6C0105756892B7CC CRC64;
MLGRCTEMAA EPTLVAMKTG SDDVEMKEPS DVGRSLQTII FDSTVKHVLG IIGQLNLSYQ
FDLQTTNNGK NATGYLPTVP RDHSIMLNMT EFVERVLGQV LRPLLRPWIP LIMQRVMSSA
SKLPLVSSFY RIGTVVAIAM DDLKFFDSPP IIDDRLSRFR DDFKTFVQRV CAQARFYQDE
LLLTCSEFVL TAPIELIAVH TMIGIVRSVL ELGRSYLPAA IVAVTALERW QKQCLNDLED
VISEVIPLLS AYLDQEALSD EESSLVKLSG KGMRNTSSNE TSDLAQLQRR ILLLLGKCGG
KISLLMSEPP SLINADGSMG SISSPFFRLE LQLSELSISL AMDPILSHLG NLATHSSVRR
VKASASEGYH ALVCYLCGKT ATYPHAAGKK SEFYDTWRGV FARIVRLATD PEKICRSLFE
PLLFQLLRWM AANSDTFPFE YSSMLDELTR SLSDSETAVR TMSARCIAVF LSLALENSKA
QANADDIFER VFSLCRHPGA VQRSGAAASI SYFLRSFKEE DGQILTQFAL PCLKNLLYAL
RLCDNDVRNR IGGVDISRDV ISKAVMKIKR GICRFPQLFL KGSTSARDVD EDSVLQRTTL
WLFQQTGARE VLFRRLCQQL FMSFSTLISK SSAEWIQKYA STHGSESVVT VLVPMSSLAH
TSITVQWMEQ LSASIESYVW CVEMLGDKAK DIFENSLTSR QESMKRKHFA DVSAQEYSCQ
QTLSWAIATF LKNGGPWEDS LKGSHWTGAY LSVLTSLCCC VMSFMKTGNV VLRNVADMDT
QSFRGAVAEK LLQAILHLPD TQVHDANSLD GIEEFCSGVI TRSPDWAQQM QETVDSMLSN
LQLCLANVNS SESFVEHSIT IGLLSFFGSK VLSAGIISFP VADKYVEMFA MVASKAMEYG
HGSPHDRLVA IAALKAAAAC GWRITDIFAN PADRQVYGPV YSDVIHFMPT LAVWNRCASE
LVSQSLKNDF VVNVLADILC QVTSFKVYPS KSADWDVFTK TLVANVKQFV SNLEAVKADT
QRVLSTLQVL RHFLELCQHC SESLVEALRM GPIPDIQDAI IKLLKQRGCS YLVKAEVLRM
FALLGPTSLL VSNEEQASKA MLDALVALVF DEFPIVSVDV ARGSKEFDVF YLLFSELLGV
IERSNSIAYL KIIYPSLKEA DNHLFRTEIK QMLARFSISL GSQTGHATSG ERIRHQLVEL
LDVLLDPTLD IAIRKTLLEE VFTPLVECQT GETLLQFYLM ESLTKKSTII SLLATLVSTA
AEVSSGGSRI GVFVAFSLVE ILYRLIDPEI IRTEINSAFL GHKNGKGREF TMLVCKCASK
VVTKTYGDVD DLVRLACCAA YNCLLTAVSR TQKQEKFFDQ ILFQPALWSN ILDLSREYEL
HAETETFATI PLSSLSAISL EARLDTNATT NAKSKRNESA ALRFFTASSL SMDTDSQTAS
TLTASLDVNQ VGSTYENIEI ELDTFNQHPC MIPLLRVLVQ MKTDFGSSWS EKAMPGWMKK
IFDVIVDPST GLNVRLFVAK VVLNVPNVFA MYSSPWLRAV MEALLDASAA QKAPEFNYIL
RDCCNLVLNS WKDVAVSSLS DTASRFVNEL VKICPELNNL IRNSNVLLIT ELIALWKDSA
SVDAGVLITY MINDDDDSKM KSAKQFAALQ IVSAMLTTGL ESELLVEEGG QTIEDGILLV
MTSKTTSLYT LAAEVGGLYL QTAGHSEGEE FMCKVRNLII GSYNEENFGR FLALLRNASM
HQPEIIDSVM LQRLSFVLPK AVAVDAWALL AADSLNNAAG NESVVKDIFT HAQSVLGRFV
AHRHAGVQLS TLGAISRLLD HLNLSELERL IANTSEGGIG TLKCYEGHDL SEYRRLLFTV
GKKLYEKDLS DQVKSRVRVS LLHGLCDSDD QRRKEAFEYW NTSAAIVNSC SDRLLSIFGS
LYSSEFDEKW ILYATNLLVG MSKESSEFER PLFTSALGSG EYAETPIDAS WEAKTQSMAP
LFSVEADLFS ARPEFTQQST SLTYTASQAD GSLGSTIQSQ LFLSKPASIG ASYSQSFGES
DVVQQRPGRN RFFKRRAAAV NSAVKDPSSY DKKASKRFFQ DQYALLKKKE EAQKTRERKQ
RQGHVSMKRT YRVGEFPDIQ ITQQDIVDPI MALCETSIET SSLVFGALFS SIVASPQFEK
SGITHELTER LEETLTLSQS SSVYVGCIVS AYFASIVRNP RLCEMLPVRP KTVGEAGLSS
GKYHISELTL EEQLLHEIQG KTRDLNLASN ELVTNCWDLL HKLLSTMHKR NLLIALSMAC
STTAESKLAL QAQLSGDLPL AIASYKKAES ILDSQMEILD GDNSFATETD ATRCRWQRRN
CLETLNNWDT LKNELTDATQ TDSDFLWKQR PPYLEQGVGH YLRSCLGLVE AKQTNSDLAS
LRSFIEGAMR DSAKMELVQS RFPVEMCLTY LSSSDKNQAR VCVETFYTNF LKMWRQTSPM
ASTSRMQLLQ SLSSMVEIDE VLSRFGRDYS DIGKMGHQSV TAFMDAWRRS PPSTGEEGMV
LWSQHSMVQN TVAGFMLNYA RDQRLYSDEI GLAVLGGKSN TMLQYANAAI SCNILALASK
MLKNYRELCN THQLPKLSVQ MVEVFVSHVL KLVDRQEHQS DKSGSNSSSI KLITRYYETA
TKMFDNVEIM NMMETAGASD KVAMGYLEAK TFASAAGFYA VNDVDDNLKE EYLSRSLDMF
KVSCKRIDAV SRKEMEDGAS SAFLRCRLTF IEFLNDLFFK RKMEKLAKLT DRKALTKLLA
ENVLGGMAAG DRECANYFPQ LCDVIAPYPD IVAEFEQCVL TNVPLWTCLQ WSAQLMALLN
GPIGKTIVAI LEKMAEKYPV ALFYDFMVTC RSSLGKFKVD LHRLEVLLSN TVMEKFVTAL
RLIHHPELRL KEGLREIAKL IEDNRMSDAR QKVEHIWKDC FSPDHPLLGT QIGRYNRDWS
RKAKRDVEKI MGKDGSKMTA KTVNTAREWI MNHFGVTPGR YGITKDMKAH LGDFAEWLEE
FDHSSCILEL PGQYTSYWRP PDPSTHIRIL SFDSMLGVLA SKQLPKRLTM HCSDEKDYTF
LVKGGEDLRL DQRIEQLFGV MNQILEADPR CCDQRLSLTT YDVIPMTQEI GLLEWVGGTT
TLKAVIEAQL QIDERCVDLK SNKRQKLELF NTTAAKTYES FLLKQRGASF SAKVVAPRSK
DVVDQFAKVQ AMIPADLLRR QLLGLGSNFE AFLLVRDQFL KSVAVFSACS YVLGIGDRHL
DNFLLDLASG RVIGIDFGVS FGSGASVLPV PELIPFRYTR QMDFVFQPYD GANLLAQEMQ
AVFDALRSKR QVVESVMNVF LHEPLLDWQQ STTTRQKALF ESKGDDQSTL QDSDVEMEDV
EEPRKTTSPA GGNETTAWLP DVKITIARRK LEGVSPALLL KEELAQNPHL KPHLSKFHVL
VDTANIGEDG ADEMVELSSL TQAQELLAMA TAPDLLGRTF QGWMPWL
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