ID W2KF87_PHYPR Unreviewed; 698 AA.
AC W2KF87;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN ORFNames=L917_16326 {ECO:0000313|EMBL:ETL83773.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL83773.1};
RN [1] {ECO:0000313|EMBL:ETL83773.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL83773.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR EMBL; KI681972; ETL83773.1; -; Genomic_DNA.
DR AlphaFoldDB; W2KF87; -.
DR EnsemblProtists; ETL83773; ETL83773; L917_16326.
DR VEuPathDB; FungiDB:PPTG_16570; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 27..171
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 286..541
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 698 AA; 78009 MW; 877A017042535571 CRC64;
MYLEKNLWPT KSSHQLPRTS AMASRAVSVF YGSQTGCAES IAQRIYDEAL EKQLDAELHP
LNEFQKSKVE TCDGHFVVIV CSTTGNGDPP DNCGKFWRYV KRRTQPEDML AKLRYTVLGL
GDTNYDKFCF MGKSIEKRMR ELGAQSFYEF GAADEAMGLE DSVEPWLNGL WEAFDKANGV
IEVTADVVTS VSDIKESTAN RGNATNSLTT EKTSSTSTTV NTPYILDNLI SYEKMFGPLD
TPTEVPEDLP RLQHSLLSVH FLGDEERQKP IHTSTTDEDD KEISSTNPFM ASLIGAEYLT
APHAERKVLR LDIDVSGSGI QYVPGDSIGI KCPNRTEDVD ALLARLGVSG DEVFSAEPVA
ATNGRAAKRK NTSIHFPTPC SVRDVFLHYV DILSSPKKAA VRALATYCTD EEERARMLLL
SSKTGADKYT EFITEQHLNF AEILHFFPSC KPPLDHLLTL IPQLMPRYYS IATSPLVDPT
RLSVAFTVVE YAVGEQRLRR RGLCTNWLNK ICQPLIGASV AASITIKIPI FLRGTQDFHL
PENSQSPMVL IGPGTGVAPF MGFLQHRYYE AKDASVTRGD AYLFFGCRRQ SEDWLFKEQM
QEYASNGTLR QLFTAFSRDQ DEKHYVQHDL RDNVELVADI LLGSDGYVFV CGDGMAMAKD
VHTALVGILT ERAGLSQEDV ELKLRELGTQ HRYVRDIW
//
