ID W2LAP8_PHYPR Unreviewed; 1386 AA.
AC W2LAP8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Ryanodine-inositol 1,4,5-triphosphate receptor Ca2 channel (RIR-CaC) family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=L917_07566 {ECO:0000313|EMBL:ETL94472.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETL94472.1};
RN [1] {ECO:0000313|EMBL:ETL94472.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETL94472.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
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DR EMBL; KI679396; ETL94472.1; -; Genomic_DNA.
DR EnsemblProtists; ETL94472; ETL94472; L917_07566.
DR VEuPathDB; FungiDB:PPTG_10899; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02026; RyR; 2.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 266..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 331..477
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 530..755
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT DOMAIN 1099..1188
FT /note="Ryanodine receptor Ryr"
FT /evidence="ECO:0000259|Pfam:PF02026"
FT DOMAIN 1291..1379
FT /note="Ryanodine receptor Ryr"
FT /evidence="ECO:0000259|Pfam:PF02026"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 353..363
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 1386 AA; 154927 MW; 9A43ECB2ADF0F42B CRC64;
MDADDAAPIA NGASPQDSAA APKTPPAPAS APTPSLAKEE SEKLRNGAPS STGAVPAASD
SPAPLKPKTK PALRAPPRRL RSGSGSGSNT SSGRERRHSG GPRPASANMG IVVGTLRRRN
RVSLRTSSLS DEEADDVVSV PPRSTAILAP RRGKKQPSLR NMASLVRSHL RSSKSLVSTA
SESTDVDADE DKRPGLERSN SSFAGVAQQV VTSRRAARGF LSMWTKDSTE TMHVYRGIHM
EKKKLDLVSV ASEYKEIKRR QFYQELVVYV VFLTLLFSLL SWLPVQDSFH QNDVVGALTC
REEGECEIKT FADIYDFAGK LRDTVCERQD VTAQWVRVGG VGFRQVRVKE LRCRVYDGWE
APCYPFYSPE VEQKTPLLGE NGTDRLYKWR DGLGELSPEI YRSFVDWLFF APVSSYGTGG
YAVDLCDLEE VEELRLDYFL SEHTRAAAFK FILLNPITRV FTIGMHVITV DPSGHIDHFA
HSSHVRVIGH EKPEQFTITE DNGDIPSKPQ LHRRIFDAVG SSMSLVREAF DVRVLLWVAL
VLFFITYCIG EATEMMTMGA TTYLGSDMWN LFELTHLVIL AALLSYMVHY YMASSTFALH
LAELREGRGV EELSHTSSQE LLTGFQQLSD LASLGSAISL LKVFKFLRMN ATLNLLWRVL
GMAMSDLMGF LVIFNLIFLG YSAMGSYAFG FALEEYSTIS KSYGTCFQML AGEMDYGRLQ
QANPRVAPLF IGTFVVLVFQ ILVNMFVAIL SEYYEVAKND ETASGEDVEY DVLARIRSFV
SACSPTVVVP KDHGVIRLIP WQQVRLISTN LVDQEETRQR VRKLFRGAVW RVVALLRFGM
KFDRRINFGD RKTHDGSAHN GNGGSGNGKD DRELVSHIRL SENFDHKTIK EMIPIGITIR
LQGDSILGDG LALKVVHHGK LSVECIVLGP NEAEAGVNAP GKVNGGLNAF APPRSISSLG
SFGDDSDLDD GAPRERVLEL MGGEKLRIPR RRLAVHLCRV MFQELKMGLL RATKLWNYSK
DHMVDDYHLG LLFDSVRADG RTSLRFDEIS RMLDLFLRKD KRKAMCSQAE VRREALQVMY
RFRKCLIDMP SREKEGHNYR PKPVDTSKVE LGHLEHLGDV LARNCHDMWA LERLKQGWQY
GEERDDKKKR HPNLVPYKLL SVEEQAFDYR SSIETIKTIV FMNYTITRAN HQRSHSGSFH
DSVSRSASMM SDIADGLGGS NSSLISGGSD STSPRANDAA VFEELGTASH PGTPAKPVPS
LLREAMSFRR NSLMGDSPYF TTYGEGNVEV YRPLPIDTTT VELPPRLLRL VDLLAENAHE
VWAKGRMDEG WTYGPQRDDS AKKHPCLVPY VFLTDDEKEY DINIAKETLK TLIAMKFTIL
DRSSKY
//
