ID W2LWW4_PHYPR Unreviewed; 2746 AA.
AC W2LWW4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=L917_01545 {ECO:0000313|EMBL:ETM01917.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETM01917.1};
RN [1] {ECO:0000313|EMBL:ETM01917.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHvinca01 {ECO:0000313|EMBL:ETM01917.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CHvinca01.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI677557; ETM01917.1; -; Genomic_DNA.
DR EnsemblProtists; ETM01917; ETM01917; L917_01545.
DR VEuPathDB; FungiDB:PPTG_06804; -.
DR Proteomes; UP000054423; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 3.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 3.
DR Gene3D; 2.60.120.10; Jelly Rolls; 4.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF00520; Ion_trans; 2.
DR SMART; SM00100; cNMP; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 697..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 807..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 922..943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1353..1371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1399..1416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1428..1446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1578..1604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1025..1125
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1532..1632
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2464..2571
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1887..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2746 AA; 313492 MW; 0185BADC300CE7F2 CRC64;
MPHRKVYAAT VDAANLHEHE LEAATGDPLI PPERGDFQLS KRSTVKTRSR LSSKQFIRAC
RRFYRRICRP VIKLYKKLPW TTRETLRVLI SLYVALYLFL TIPFRIAFYY EPLETHVRHQ
WTKELSIFTT LDIVADVIGL LEFVSFYQIW KDAFSQLSAS VSFELNKKLT RDANRLKTPK
ILTRTASTGL RRGKAKWTIA SIGPLSSIPG AGMDDSSAHR RFVLMRNIEL MMEVIGLLPT
EVIPLSSGAY NTLHLARITK LGRIYRLRQC FERFASIYSD RSWVQHLSST GIDSLVRNIG
MCAGLCHYVA CGYMLLAHAQ CGLSFEACDE HVETSWAIRD RLSGATVARK YARTLYWASR
TIVLLGYDDV TPVSDGETVY ALAVILIGAL FGSSLLATFL FIFRFRNARY AAFATHVDNA
REYMRSQNIT RAVRHQVIEY FSYCWSTHHS LDSEEALHLM PKHLQTKVIS TLKASRVKQV
CFLMKESVEF INLLALALVR RVYSPADQIT EPKFNAQMFF VIRGTIVLSA FNGSNAKECQ
TGDFFADSCL LFPEKYEEKA VAKTFCELYV LAKAKFDEAV THFHRGSEPE VRERMTETWI
KYSTQLQKTK KLLGLRGGHE NGRRNSHSGS THSVVNNDVT SDRKRGVSWQ LPGSVFRVYW
DTVRMFAIVY VAFEVPFYSV FIAMTDDQGM FAEEPEFGLR YALTLMAEMF FAADLVLRSR
YFAYLDHSVM LEVVQPSMIF AAYRASGFYL DLLAWLPVGI VLDSLPIDPI RGRLSLLRLL
RLVRVRELPG LLRNISDYHS ISSKTHLVLS LLLGVTLMLH IVGCVWFEMA WTIQRTTLED
YTEHDMADLS RADCLQYATQ FQNCSWVKYD CYAHIGAVFP LQDPSSMYKY PFAYLRSVYW
AIVTLTAVGY GDIVAYSTAE SYFAAFWIFV GGIINFGVVG AMSSTISNVM ATRHHHVEKL
NTLNSILERM DISEKLSGEI RRFYHHQFVE HKRAYESQLL SHLPDQLCYQ ISSLLHSEAV
KSISLFDSAS VEFLHEITGK FRHRSFQHGE TICLEGDICR EFFVFLHESK VNVFYHIRKV
PIRALHQGDC YGVSEFLLRK TYTATLTAAS LVNASVMSRE QFDVIQRKFA SDLSDVKEEA
QILWLDQQKR MRRVVNNLER LKLQPHMMQT TTLFSQHDTM VTMNGKNGKA IVRDADTRRT
AFTSAWNAVI TCWNIYNAFF IIFRICFHSH LHFYAGTSTV VWVADLACDW CFALDIYLRL
FYFGCPEVGF ENLFTRQEKD THYLHSSTFK WDLLASLPLY APVASGSITA SLCRLPRLVR
CVDLFVYLDD VIVQIQQHFA SHNVSAYLSP AKLMIILVLA AHFVGCVFLL ISERECEHVE
QCWMEHDHLL HEYHHSVPIL YAKTFYWAIT TLLLVGSRES VPRDTAGTLW TSITCLVCTF
IIGHIVGEIS ELILELGKET KHYKSRIASF ESFAKEHNLP TTLRECVGFF FRLQFEHTEG
LDLHSTVHDL SANLRLKLML EIYGRSISLL PISRFLTPSQ INNLALRLQS ELFIPGDNIL
VEGTYGSRLC TLRKGVAAVF WTSSVTSVAI LMEGALFGEV AFFLSGQRRL ATVKATTSCE
VLYVTKHDWR ELWTTDGDLS DTQVQKHALY SILDWVHGRL LRYQRASLRT AKKAKRLLAT
RQTQQVTTEN RGAKARLSGS PSVIPLLTKK ATSRLSLFSE VQLLEKKTQY ILLKADALAN
KFHQALAALH ARRRISSAVS IRSTRLSISR KNRGNSNEMN RSTVGDVVAP IHQTSNTKKD
IHALQFIVDL NPVNKLVRDS LPTRHVRRLE TESWTSFKIL AAVQHTVRKL MDELIPPETA
SMRVTIAPNA HGEHRSHSRM YHARRLTRRQ SSCSPDKPNN RRPNGAHFGA TRISMVAQTI
GLGGNDPKRR FSTVATQDQQ LAGAPVMTTN VKMVRSRSLP LFGGKYFEEL HKEGDRNMKS
HDGYTSRATI DFEIIQRCQR PQYTAQLQWY HRYRRWKNRN HDARKQSVPR RINDARWLSS
SLRSTLQLLD LNRRTSNGQR PSLIGKFQLP SDQSETIDPR SREVIKRIKE LGRLWDIGML
MIAIYHSIVT PFKLCFASDL TEFSGSSLRL WSGFEVFLDI LCVFDVGYKI RYASLTVHSV
GTSLANTHQG GWRRIFTSNP ALRSDILAML PLELLLCATD IRIPVSSEHA TASWWTTRWL
LRMNRLLLAH RIESLSEQFF QYMIYDRKIP VDEAFLYFLK GLASYVTMGH LLACIWFITS
ELGFHHYGTS WLSTSGMLTF ISDGSTEVEH TARMLNESVT TFYLESVSLT RKYLRSLLFS
MECISTLFYG DILSMNPLEL VAEIAITLWS IYIYGALVGA QGELLDAQAR REAAFEQSLG
ELQHYLVENE VPKKLKRQIK SYYARVWRRR KGEKEFAAVA HVSHTLHEDV VLATLRGFAA
RVAAFRSLDE HFLRGLLVCL QYVVCSEGEE VAMKGDVDRS MYFIAQGRVL VKLDSGESIR
ERGEFFGELA LLYGVSRLET CVALALTELY RLDHQPYEHL LQDFPQYRER NKLAWTSPNT
AAPDRAMLEA LMINFQRDGD SIQTPIAVPA VKLDDVVANA ERINADLPYS YIYKFIMELL
AQLQRVDPLE ARDLVLQGRA GARKQLKALL GLATSREEIA RNEIPVPEVP EVSAPPPLGV
EMVSTFQPQC KKEPKDQLND KSVDGFATKR RGTALVNEAL LVQEYP
//
