ID W2N4Q2_PHYPR Unreviewed; 649 AA.
AC W2N4Q2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=L914_10955 {ECO:0000313|EMBL:ETM43667.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETM43667.1};
RN [1] {ECO:0000313|EMBL:ETM43667.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAC_01/95 {ECO:0000313|EMBL:ETM43667.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica IAC_01/95.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI693561; ETM43667.1; -; Genomic_DNA.
DR AlphaFoldDB; W2N4Q2; -.
DR EnsemblProtists; ETM43667; ETM43667; L914_10955.
DR VEuPathDB; FungiDB:PPTG_13501; -.
DR Proteomes; UP000054532; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT CHAIN 19..649
FT /note="Purple acid phosphatase"
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT /id="PRO_5005149865"
FT DOMAIN 198..304
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 319..538
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 558..615
FT /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 649 AA; 72876 MW; 62198B7E2437F341 CRC64;
MVASKTSILL LLLQAVLTAS ISSLVAPPPP RAAVVARQQE PEDSDDFEKR EVENCVPYDI
RSSVVGRRAV VEWATRRTYI RKVKLQKSHD PSPVLANPWR SCHDVAADVV VRYRRLGDND
TMLVSGDREA PFTSKEAITY TTDEATFTTH TAFINLPEGE HDAGYEFIVG SVFHGWSAVH
RLGVNLPFRG DEAERCRPKH VHTAYGRTPG SLAVQWMTKE FCGKGNAQLQ MVEGYHARIE
VEGPNATPVT AWANTTLFED DGEKQSKRWL HVVRLEGLKP DTRYTYVVGN AYYTSWSIPY
VTKTAPAPLS AGEKPKPTRF LVTGDIGYQN AATLPMMQSE VAEGVVDGVV SVGDYAYDLN
MIDGHVGDIF MQEIEPIAAS VPFMVCPGNH ETHNVFSHYS QRFRLMPSNK NEGVQTVHVG
GRSKDAEPKE VPNNWFYSFD VGLVHFAIIS TEIYFKKTLD VDGDVIARQE AWLEQDLAKA
NANREQTPWL VVIGHRPMYC TSDDTNCGDK AAVLRDKLED KFFTHGVDLY LCGHQHNYER
AFDVYKSQTW KRTHNMRATT HILTGASGQY LTSIMRKSFE RPVEVWDAFR NSIFGYSRME
VMNATHLHWQ QVEADPENPA ARGLYGQVID DVWLVQEQHG SFAPVGTAS
//
