ID W2NHP9_PHYPR Unreviewed; 6051 AA.
AC W2NHP9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN ORFNames=L914_08051 {ECO:0000313|EMBL:ETM47214.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETM47214.1};
RN [1] {ECO:0000313|EMBL:ETM47214.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAC_01/95 {ECO:0000313|EMBL:ETM47214.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica IAC_01/95.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI692724; ETM47214.1; -; Genomic_DNA.
DR EnsemblProtists; ETM47214; ETM47214; L914_08051.
DR VEuPathDB; FungiDB:PPTG_11709; -.
DR Proteomes; UP000054532; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 31.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.60; Cadherins; 30.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF422; NEURAL-CADHERIN 2-RELATED; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF01833; TIG; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 30.
DR SMART; SM00429; IPT; 3.
DR SUPFAM; SSF49313; Cadherin-like; 28.
DR SUPFAM; SSF81296; E set domains; 2.
DR PROSITE; PS50268; CADHERIN_2; 32.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5434..5454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5520..5543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5555..5574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5617..5639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5685..5705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5711..5727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5829..5848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5868..5895
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..169
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 168..271
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 270..377
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 376..480
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 479..584
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 592..688
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 689..807
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 808..908
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 909..1034
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1015..1123
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1122..1240
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1238..1340
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1372..1441
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1441..1549
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1555..1670
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1670..1774
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1799..1893
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1895..2003
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2004..2113
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2141..2223
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2223..2322
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2356..2428
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2561..2668
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2674..2765
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2766..2873
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2873..2981
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2980..3083
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3091..3183
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3210..3310
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3385..3491
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3492..3603
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3604..3714
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 5913..5941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5981..6051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5913..5934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5986..6000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6021..6051
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6051 AA; 654873 MW; E063BC826FE93884 CRC64;
MLQVANSTLL NFEVRKKLVV TVCARDGGSP SLIGCGTTTV YITDINDAPA TITPQKCEID
EYIYDYTDEQ VGRLVGTAVC NLTVLDEDNS GSANTSWKNH VWQVVEADSG CPFNVSAQGQ
VVVSTPRSVS YEQQKVWSLL VQAMDLGGLS STPQRIEISI LDINEKPQIN ATTFYIDENS
VAGTLATGII SVFDPDIRSD GQSDTPIVSL VEEVDTFNVA NNKIQLQRDT LDFETKPSYV
ISVVATDKSG AKSNVQKINI VVNNVNEGPT IDPMQVSILE NQPAMTKILP AVKAKDPDGD
SVSFSLVSET PQGAITRAPT AFGIDTITGV LFQQVDQLNY EEAKEYALVV KARDTAGLFS
TAIVTVIITD VNEAPSIRDQ TVSIRENVSI VASVGQPFAT MSSDPDLKNG LEVLTFTLTN
ASQSPFSIDS KSGQVVTSAH LDFETVSVYN LRVRVMDLNG LSDESNFMVT ILDVNEPPVI
GPFSISVPEN LVPGSIFGDP IVAIDPEAGS KLYYDLIGTS DIVTACIRIN SSTGQLSLKI
DCSLDCEAST GSTLSVVVHV TDGEFTVSTK GTIYIIDVNE APVLVASEST LLRENSVDET
IVTLIVVEDP DVNEYHQFWI CEQSHSNTFR IQPTGLNTAE IVVMDSSVLN YEKNPYLCVD
ACVKDRGNLT AKARYTINLV NVFEPPYFVQ DIIQFTVEES IRVGSDIGSP LTRLVVDEEN
LNVDIGCSVE ISIVNSTCGH RASFSVDSRG QITLSSGGLD YETMSTCVVY VLLPATSIYN
ANTSSLPLVD TITVVLTVTD VNEPPAFQQN LYQFGLAESS VEGALIGVLP ATDVDTGDVL
SFQLLNIETG YEGVFKVSVS GEITLAGLLD YEKKQSYQVS VRVLDRQGAY SDSSVVISIR
DTEEPPIFQA SHYSFAIREN SPVQTVVGDV VAIDSDTYQN KTIIYNIISG NNFGAFAILS
IAGDGKIVVG SQQALDYERQ ESYTLLVEAT DSIQGGVRSF ATVSVSIKDV NEAPQVHPVR
VYIPEDAVIA TPIFSSSTLN ETFTGKLFAS DPDDKDTLTF TATDSTDTFS IDSVSGAVLS
KRLLNFESNS YYSIYITATD EDNLSATEIL EIIILDRNDV PIVTSTTFTL AENQLRDSVV
GVTQITDEDF NQQHFFTLVE TTLVLRDNST EARPNNDVVS VGLSSGSIQV LNESVFDYEV
VRQVVIVITV SDDGNPIRQS AGSLTIDLTN ENEQCAFPEV VLTLSISENV IGVAGHVLAI
DPDANTSLSW GSLSYYMIDD EMSSNAVSLS NTGEVLVKTP LDFEIQRKIV FKVAAVDGGS
LVCSTSVQLL VEDKNEPPVI QSDHFWVPES VDGNLDWVRA YDGSHARILV WDPENDTVTV
SQNSSDYISV SDDGLIYLEK PVNYEVKSCY DLLVTATDSH GLQTSAIVRV EIVDLNEPPV
FTPQPTLTIA EDASRGAVLG VVGSAYDPDE YDVVSYKLES ATDRNGLSVD MFMIHSCDGE
VRMSKSSALD YEANDRYVLT ISAADRAGLK AFSKPLLVEV TDVNEPPQCR DEILSILENA
TANERFGPIE WSDPDSPIKN NITVFEVISD TDEIGYEIFE IQWGNDQYWM ALQNSGRLDY
ESMNLYTVRV KIGDSFDSRN DPSATSVVSS LSSTCTITIH VLDVNEPPIV SSIIKREVEE
NAPLYVNVGL PIEVNDPDAA DVLHYSNANH QTNPVPFTMD YNTGQLRVSG DLDYETQALY
SINVIIEDSA LNTITTLLEV SIIDINERPQ LPRNCFVRED GITENRYEYN KDVCIEANED
VEVGALLHHF EALDPDSNQR LFYSVSETSN PFVRVVQNDD RSCELIYSRA IFDYESLKMH
RVQLTVTDTG KGFLSDTVMV FIFIVDVNEP PSLLQASTLN LVIAENSVSG QLLGQLHGVD
PEGDSFTFSL KGSSPVSNTI EIRDDGQIRT TGASIDYEAL AKMNSLWAEP VLTIRGTINS
FDAVSTAFTF VIAVVDVPEP PSFSFKQYSL AVHELASAGV IVGALQATDP DFNDTQRFTW
DTTDAATKAA SSVFDVDDKS GIISLIKKGV LDSETTPTYK LKTVVTDSTG LTDLSTVVLT
IVNDNEPPSC PSLQCWVLEN AAGVFKGLPG TQGLCQAEVQ DLDIGQKHTF QLLSYPDSSI
FSIDYASGVV RFTSGQQIYA NFEVQSVYRL RYQANDIPDT GVSLSCSNEI VISVVDVNEA
PAISGRQSLI VAEMSTDGTI VGTVNTIDED NGDVLTFSLL DSYSPFTLET DTGVLRVANG
STINFESAPV MYITVAVTDR EGLQVVATLT VTVLNVNDPP ILQSANFTAA EYALSRNGDT
FGTRNLELLG SLHCFDEDTS DELSFSLLDD TSAFVVETKS GMFYAETRNL DFETTRGYDL
TIQCSDGQTT AISTFWVFVK NINEAPIVTG QVYRVNENTP IGTGIGFVSV SDVEHDDENF
LTIVNDATRS SNTVSRLQDQ APVFTDSLDV EWMNIPEILQ NAFIVTTSVS EPLSKVTLNL
ASSGDIFVLV EDDSDVIPAW ISQNAFVKLE GQTITAQSST SATTYEIYIR ANSGGDFVIP
DTTAFNMLCV FGAYPSPLEY FIHGSRSNWF DVSTSGELLL ATVTLDYESI AAIDQPVQIS
VNVVDSGGLM GEATLSIYVD DVNEPPVIIS CCLEITENPT IGSMIGELSG TDPDLSDQIT
FELAFPSTDI SLTSSGNMSV RDSSLFDYER NSLVTVRVRA TDRGGLVYER EIQIKVLDVN
EPPIFQQSSY YFGVPENSAS GLNFGTPIRA IDPDRGQTEN LRYELVNKND GGLPFRLESC
SGQLAVQWDK LDYEGTNQYS FGVRVIDSGY PVALEAQVQV VVDILNVNEP PQFAESGSLV
ILENAPTGTF IGKIIATDPD QASVLTFRTN ASNYVSITDS GELYAAEPFD YETMPILFIS
ITVKDSSVYC DPTLDAASCK SMSTIMNAVV LIRNVNEPPS LTAGTFTILE NLSPGSLVGK
PVKVVDVDGT VGNSSGFWIK SGVSSGNASE FLIRSDGQLL TLVPMDFESK TEYELEIAYT
DGEFTSFLDI KVSVLDENEP PSVVGGITGY VQENKPAGTT VLVAQFTDPD QTSANVFTLM
DSYVPFRMDQ LSGELQTTRA LDYEKDPTTF NLNVRVCDAA HTSLCGSGFV TVNVLDVHEA
PSMDDLICTQ VENTAVVLTE QGASACTFIA IDPDKASCSF YSIVGSTSSF QLVHDTIVNG
VATTKMLEPT LCTSGRVGLS WKASSLPDYE VLSQHVVTVR VSDETVKTTG FSADSRVIVN
IVNANDCPTL AALSFTSNAT SGLIGIDAMT GQLTAARAPS GSELVYPAQY TVTVSVTDSS
VSRCSTTADI KVFTTKSNFA PVWSSTLPAS FDINENSATG TQAGALISGF VEDPDNDVIQ
FTLQSKTDAY CADTFSVGLT SGAIALRAGI VLDFEQRRTY ICTVAACDPF QMCSNHDVTV
QVKNVNEAPV FNDQQYKFVV QENKAPNLAL PRCLSATDPD EGDGYALTYT TSCTNATDCS
LFSVKVEKDC SQARCARIIV KLSLNYEARR HYSFNLIAQD PGKLTAVTTI VIEVEDVNEI
HSFVDFTTTK SVLENTAIGS AILRVTTTDP DMYSYPFGTI QYALSGMTPP GLNVFRIDST
TGDLIVNGAI DFEAVQAYTL TIEARDSSGI NALVISKDLI VTVKNTEDTT VEAFELVADS
SRKLSTIGGE KFILTGTNMG FKQRADGSVV IKLLTVQYGA YGTTSPYTAT NCFLVNGNTG
VECTSAPGVG ANLYWNITLV MTVPTIGDTT FQASSSVPLA SYGAPVIDSV ECNTAFPTNG
SSVDNIIIYG ENLGSTQLSS SDAQPIVLYG SDFEVQNCKL HTSTRQYVTC RSVLGTGTNL
PFTLVVRGQA SATFATSCHY AAPIITAVTM ANGLQTSGSA TVVVNGSGFG CQGCANITVW
YMNTLHSSEL NDCTVVVDHI QLTCMSLPGA GGDFQWQISV DNQLSVLTSE IKTAYDLPQI
LEVMGFKDAS TAGGTVFQIR GQNFGPDTAI FVDPVVEYSF DNLTILRAVH CKRQYTDPKN
HNLIQCESVA GSGSFHSWRV TIEGQTSLWT TQNTSYAGPI VNKVFRPDGE AEIRTSGAQQ
VVITGKNFGI MNESVINRVT YGINGNEFTA TNCSIVINHE RILCTTAPGV GNRLAWIVTI
DGLTSATPTI SYAKPYITSL DGEGAVNALV RGGQTVIIRG GNFGPSDVAI DMISYGSSGR
DYQVTEVIKH NDSTIVCTTT PGVGANLSWI VSVGDQESSL STFTSSYAPP VVTSFYPTVA
LTDGSTQVTI IGENLGANVT FAASRMMFSP PQSSLSTRRI PTIAFGDFGN SNSSEYVVVR
VPVGYGSGGS LQLLVGTTSV QKSALLPISY GLPLIESVFT DEGPSECLPS CIQLTITGTN
FYTTGRVLVS KYPVTTSNFE AASYESSVDF SSWTHDTIII PKYVGKLGYV TIVIGREKIL
SNSAPFSWDD PSILDWYTYS STCGVLDCST SYRLDGDTKL FQTEPIGTTG ELNYLSATNG
GATLSLYAKY VGRNPRISIG GSTCNNVVVT TPVIPSSVVL SGAISGVSSI RLISCSVPSG
QGSMLALIVT SGTTLSSPRY FSYIPPSVDW VGSSATLSPT TGKMVTLTGA NFGTNPIVSM
TSSSNASALL TITTFDHSHA TVNIPAGEGQ NYTLKLIAGN QEKSTTFSYN PPVISSIEVV
DATTAGGSTM TIRGENFGTR ALSNEHAVSL GDAFSCSIES IDHDLILCTT SEGQGSGHDV
VVTVSGHANV DKTKKFSYDP PVVYSISRND GPTSGYTCSC TDPDQPCATL EAPIKCQYLE
ASSTSSSLDS YCVQTILDGV LQKVTLTVVE DVYSSNKAVY LSEETDLQLL YTGGFWQLLQ
NDESLYRASA STVSPPTTGW LDVTVDPPVD ATMKVYPGSC SKTASRACPV GTALCERVAV
TIVGKNFGVR SLGWHLELAS SDGSIEPVKV TNDDIVYFSH STIKFNLPPG QGISRIVNLT
VSELQLVNKS VEFDYQTPEL IGYETSTSNL STCGGYTITL YGKNFGSARA KVLIGGRDAR
VDGQSSHPKA CGSDTCEYSS SGPCIDIDTL VCYPSLYVVS PTFNFLDLCD DDKGTQIMCE
AVDPAVDLAE NLTSHSDFVI ETTVPAGYGA DLEVYVVVDS QPSNALTFSY NQPVITAQMP
NQPDANGANA ITIKGTDFGC FPNDAITISF ASTDTVQPIS RKLGAASSMS DLETAFHGES
YRQLAETTTP ADATNTSSNS TGTIVWNSSS ELIWYPPKTK AGITSITLSV GGNVMSASSQ
TQLKFQCSPG YYRTSTEFCD ECPEGATCAG GDEMPLAKPG YWREGEVVFA CDPMYACLGA
NRCAVGYMDI RCGECEKNYH KLNAECNLCP DNKWGSVAIV VICLGVASIV SYLLTRKGVS
LGLLSIGIDY FQTLSIFGNA RISWPASLIN LFSTLSAFNL NLELIAPECF AFQVSFVNKW
FIIELFPLVV AATSLGIFAA LYAYKRFIKR RRTRLTSHLP QLFGSTLVMM YYLFLYLTRT
TLDVFNCVGT IPSDGKLYMV AIYTQCFKPG GIHMQLFPFA VLAFVVYSLG YPLFVLLTLS
RNRALVMEDQ LLRAMQRGTS RRTNPNCWVF RKKFSKLYYQ FKPDYWYWMV LIILRKFLLA
GIGLLFRQDP VFQLATATFV LFVNYALQVR CRPYMSAYET QRVLADYAKR VLLETRRAKA
KGEAFIQPAH LRLEMHASTV TAWKSGHGDH GGSGVAGSAA SPGIRGANEA ILASQEPQNL
VGYLWDHNTV EACLLFSASL VLLAGVMFES GRLGSSETGF TSASAQMLAI ATTMLVVVSC
VYFALVLITE LVVALRPDYY KRITRVQKVF SSPRRHLKDD TETDHSKHRP AGDDDSDNDD
DDELEMVATM TQNPLHFNRA LAGARGRAMR ARERDALAAL QDIQRRGSNP RRNSPQHQSE
RGVLSDEENV SRRRRSQRRR GTKRDENLMA ELTSAIEETD DVNKQRRGAD D
//
