ID W2P3P8_PHYPR Unreviewed; 2620 AA.
AC W2P3P8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=L914_01862 {ECO:0000313|EMBL:ETM54858.1};
OS Phytophthora parasitica (Potato buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4792 {ECO:0000313|EMBL:ETM54858.1};
RN [1] {ECO:0000313|EMBL:ETM54858.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IAC_01/95 {ECO:0000313|EMBL:ETM54858.1};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica IAC_01/95.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI690888; ETM54858.1; -; Genomic_DNA.
DR EnsemblProtists; ETM54858; ETM54858; L914_01862.
DR VEuPathDB; FungiDB:PPTG_19058; -.
DR Proteomes; UP000054532; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 4.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 4.
DR Gene3D; 2.60.120.10; Jelly Rolls; 4.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 4.
DR Pfam; PF00520; Ion_trans; 3.
DR SMART; SM00100; cNMP; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 4.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..915
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1163..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1309..1327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1352..1370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1382..1401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2082..2105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2366..2387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 486..550
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 994..1092
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1486..1587
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2466..2580
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1898..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2620 AA; 298766 MW; C354B7DFF4E1BFAC CRC64;
MSTVRERAVS SAANGELWQQ TQQRGPLARI LYFFRRRKRG WFMGMVILEL LYVFVSVPLR
IGFLFDPYTT DDWSSGWTVE LTVFTVLDVL ADTAGFTSLM DIFAAQRREQ AAVAADAIGA
IGARRQRSNQ GLNKQHGRRA SLISGIRDSM QVAWSLNTII PKRHRHHGIQ RPILLEMISM
IPLELLAFAF GPNSLHLLRI LKLLRLYRVP GCMRELKQMN TGSRIVQMLE YTGNVVLFNT
VMLGLAACHW IACGYMAVAH LECGIDFMLC SKARTVLTTI PGAGAHGVPK GIAKVSPTGD
GSGYTCWAIE DYLVGTNVGR QYGRAVYWAS RSVVTAGFYD VAATTNVETL YAIFAQVIGA
IFSTAVLATF LFIFRYRNAR MQEFMAHVDS AKEYMRVRHF PENVREGVLG YYKNTWATHH
ALYHDEAIER LPGHLKVSVY SVLKAKRIQD VAFLSKESIE FINTLALRIE YCVYSPKDWI
IEKLPDGMYF VLRGSVQLDG PRHPQTAFAK AGGHFAEGSL LFPTRSEERA RAQTYCDLYK
LPQRSFNKTL AVFYRENAHQ HLEEMRSMHA RHDQQEQKMK KMLGRSADNA ETNVNANNSG
GRYSVTYGND VRSVKRPRIP WRMPGSSFRK YWEHARLFSL VFVVFEVPLY CVFDADTFPF
GAKSKYSLQS ITSIIVEAFF VVDFVLRARF FAYVDQLALI TVSDPSYILE AYRENGLWFD
LLAIVPLPLV VEFVVHRGHG WTMWLQISRL IRLLRARYLQ QTIQEFSHIR GLSSKMQQAG
TMLLYVTLTI HVAGCLWFLM ARFSVLETEF EPILEEYTRD RCLRDAGLHG NCSWTVYDAY
GQIGTTFKVQ DPEHSIYTIT MAYMRSIYWA IVALTTVGYG DIVAFSTFES YFAAVWVFIG
GIINYGVVGA MSNIISNLTA SSHHHSEKMN SVNVTLGHFR ISESVRVRIR QFYHQQMYEQ
KVTSEVQLLD GLPAQLRHRI SSILHAESVR KVPIFVDAQN ERLLYELTGL FRRQLFQRGD
PFFAEGTLCE EMYVVVNGRA NIFSKRVGTL PVGALSAGDC FGVCELLLRK SFNTTVVAAS
VVDASVITYS AFVAKIEGHF PAEMESLRLQ ATQQHIFDTL TLEAVIDNIK SRSTLMKFTE
KCTSMFEEKE NWGQHKNKMR IRLYWDLIVL ILDVYNAFQV TFRIGFLAHP SSGTRVFLVV
SDFVGDAFLL ADIYLKLYYF ECEGAGLMNL IYREERSETY KGHELRGDLL SSLPLYYVGS
SFLAMSLCRL PRLLRLHQVP SMIDSLIMRI QQRFSAGGNI SAYLSPIKLV LILLFTGHLA
ACVFYLICHT DHNHKNWTHH DPIVVMEHES TGVFYLRAFY WALTTLTLVG SREIVPLGLP
GTIWATFTCL CCAFIVGHIV GELSELILEM DATKKELKER ESHFDQFAKD HDLPSSICTR
VQHYLKFQHH YLKGMDIYAT FSDLSPNLRV QLMMDLHGTT LQNLCIAPFL NQTQINGLAM
RLKSELYIPG DTIIVEGDLG HKLYIVKGGT GMVLWKSTGT AVATLTAGSL FGEVAFFLRG
QRRIASVQAT TCSELLVLGR RSWEELLASS AREEAESTER ALIQWVQYCL KGYNIMTVEI
VKDIKSGDSG TSKTPKNIEE LRELNAMKMH DTDNAPVIDP LRYVSATTLE ERKVRQLLRK
TAGYGGKNKA EFAAPSILTI VFRWVRDNIL PSGRKAAKLG RVYADNSDFD ARNEPVTTST
SGTRRLFAWH TPRNTTSGLS LHKMKSFKNG TAVQINPVSR SMREYYRDEQ LVEMEEECWR
RYKVSLFMAD AFTGEVIKQS PAVTPVSPQL LVQPQPQANI ILSQNTSRNE EDSTPTASKA
ETKIRVSRKT FCGAMLPGAS PQRATRTLVT TDGMRFLENY ESRNRPSERG LSRKRRPRGS
IHGHELHQSF GITNLPSGAA RAHRRQRKLK RSQSLPLFDR HFAHMIREEL QDSNAKESES
KLNLGFELLQ RCRQPEFSSL FRIYLTWLKH EKRWSQWYSQ QTERFTWLRS FSSSSSASEN
SRTMSFFDSG HDRTASTSSL PDRSTSSKAE DFVNLLSRCY RLWEWVVVFV GLFYAVTIPF
FVCFASDLET FHEDHEDEIA LAHWERIVIC VDLVCIADFL LKHSAFRRVL ALSDGGSTDV
PTAAPQPLAP PPLTSMRSTK SLVSTAPQPT IQKRKSWWKQ HVNTHLWLDI MTSLPFDILL
YIPPLSKSSM TDHRWFYLSL FQLNKIPRIL ESIEASERLT QFLAVDLNLP IGESRLHFIR
TVCVYLLSGH WIGCLWFRLG LHAYHFYGDS WLSTYKMLAV DYFGELSEIP TSRRYLRSLH
FAIGSITTVF YGDVVSMNAI ETVVEIAFIV VCILIFGVLV GAQGEMIEAN YKHKMLFEQN
LMELYHFLKN NDVPRDVRQR LRLYYMNTWL KYHGHDDLEG VRGLSTLLVE DIAQYTLRSF
ANRVSILKSC DESFLRSLLT CLKHIICSSS EAVVRKGDVD RSMYFIAKGK ILVQGPGFEL
VKQEGDFFGE LSLLYGIPRS ATCSSLGVSL LYVLEWETYE RLLADYPEYR EQNRREWVIV
STVLKTGESR FRSIIDIVAR MEKADWVLVD QIIRKAKSLK
//
