ID W2QET4_PHYPN Unreviewed; 2890 AA.
AC W2QET4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPTG_10264 {ECO:0000313|EMBL:ETN11366.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN11366.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN11366.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN11366.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIEZO (TC 1.A.75) family.
CC {ECO:0000256|ARBA:ARBA00007821}.
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DR EMBL; KI669579; ETN11366.1; -; Genomic_DNA.
DR RefSeq; XP_008903175.1; XM_008904927.1.
DR STRING; 761204.W2QET4; -.
DR EnsemblProtists; ETN11366; ETN11366; PPTG_10264.
DR GeneID; 20179906; -.
DR VEuPathDB; FungiDB:PPTG_10264; -.
DR OMA; PGRDFYT; -.
DR OrthoDB; 50275at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR027272; Piezo.
DR InterPro; IPR031334; Piezo_RRas-bd_dom.
DR PANTHER; PTHR13167:SF25; PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL COMPONENT; 1.
DR PANTHER; PTHR13167; UNCHARACTERIZED; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12166; Piezo_RRas_bdg; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 820..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 852..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..958
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 984..1007
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1013..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1037..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1237..1264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1276..1297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1405..1428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1434..1451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1472..1497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1517..1548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2327..2346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2372..2392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2404..2421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2433..2451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2550..2571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2793..2814
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1616..1714
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1718..1849
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1181..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1869..1908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2230..2260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2890 AA; 326077 MW; 418F2531D424F3C4 CRC64;
MSRPKTRRLG INGTAQVEPF RLRHSLSMRR PTASFHSQPG VEPSSSFIGA DGRILLTPTR
PQDAGAAYGQ VATPSFGSFH REQSQRLHAS GLHSARSSQR RPGRKLSLRA LSALRMTAEV
LFASCLMVAV GARASLVSLY YLLVFCYGVV QSFQSRSITL LTLAVAAMAC VCHGAIKGVY
GDASYAGADM ADLFGFRPMN NSTEYLRGIG VDVLVLVCSA IHYWYVLKRL NSRSKEQEEE
ERAQQHFDLF EMGERLMNGK EPKRDRRRSM LRAVELFSAV FLFLTSVSVP AFASGLLYVV
LLVRLIGYTV FVRRMTIQEL LSRRSGVKFS SYFLGPGVTK LVLSLSLVTI VAWYCFHLDQ
LADDDMVQTI ANYLGFANFR EGGVQWQYFF FAGFLFLLFV SCAKLHNLHS EAKDAEASGT
ASLASGFSQN GPTAVDLGAV DAEVAQSLLD QRNRATTADI KELLSKQSIV VRAFARDGGL
LLGSAAAIVW CVSYPSYLSA PFLGLAFVTI ALFGVLSSSL FMWLLIAYGT LMAMAEYTSN
LTIDFVPEDY TTYGLGVFDY PFLDIGAHTL CLVFMFLAIR TQWRYQDILR ESRKRRNTAK
VADVDEENHE DVVADRASFA NFVRLAKMRS VSIDRGLPGM VQLLILIRDI QQIQQGWRSA
ARLWLVDAKR VVFTHLDALV LATILIVALS THVSFLQIGY LVLAALLMLF FEKRRRFWRV
LLLYALGACF AVFIRNIDCT ESSEMELIGL QCYNPGLYTW KSLWPTLFSA QLLIIFQLVF
QLVIYVANSE EIEERMRTKE HVRQNPVFFV SRLAVEVDNW FRICGVLLCY TAFIVVAIQF
ESGPTTLSTN MVGALQLAMF LIIFGNHLGG FQSAPRTSLR LKLLWSLALL IEVLILVARY
VYQFEEVAAY LEKNLFTSSF ISAQDFGLEY HASNSGISDV FLYLLPTAIM TGLCFWQLSS
MMKDVTPYDL FTAGRSRAAD GIRFIMDTLQ HLLISFSATA LVIVTMWVAL DQISFIGLLY
ILILIVGRAL SDSWKQLWFP LFCLASLSML MKYLIQLSTF NTEQADAGVL FKPGDDSDWV
GTIRLDERYE ESEGKSKLWD LLSGEFWIIL LCSFQRMAQY FDSSSSAQRQ LDLEELTARF
EEQYALYAAN NLDSYHPTSS CEVDDDDDDL KDRARAFTYD DESMPPRSRK TQQSEGNADT
KREDHAHLSS ISSDDKDFFS CLRSFGTTYA SKASVNVVML LLTVSCFVHQ DIIAMIYLLI
VYSMMYAYPA TVCRRWWALA WLLSLVIVLE YAVILWLPPF MDVEMEETFP WRVISDTYEK
WLMLSNQHKW GLMADFVALL SVYLLPDSDR FTEEEEVITV VDESAPLLKL THDNGLEEDA
EGATKTPYPV SSGEVTYTLL MRKYVWYYLE FVFLANWLPL LLLLVFVFGA KQGGAVSIAY
LLGSLVMLYR LDEAREPSNP WIQYLRKWNW AHLFMITVIN APYVYSALSN CLIGAKADND
DSCMSVSNFL GVEANKVPYG LIALFVLISI QCEILIAPTY QTVFAILVSE QNRASVRREE
IVRDFYRRRT EQWYKMKKDK NAAIQRLKII VSKLVHKVEE LMDIALGLHH NLPPMAPSKP
IAVERSQNSA TISWEKPSNS YHKIRYYRIS RQQFPSLTLL GDFGDIVEIS GDRCEARIEG
LRPGTSYQFK VCAVSRMGEG PFSVASDPIA TYSLNLDGST TAGWMKYRRE KLPAPRLGFF
VSWMKAKYLH RYVVIDSSHL VFYQDEERAL KHRSRKHRKR LKTSFKWRDV ISLKLSDFKV
QYDDMSPSLY CFEVVVRHAG SRGDVKYVFQ SELSKEFNMF LSALAFAVPR EALDGSIVEC
LKERNLPNPL DVAPPSQNID EDANFDENKS EWSSVTGDES TLGDPEDEEF DDKSGFAWHT
PLYRLLYKFQ NAGFKLETPQ YEEDDMNEPT IPEIVQLVIN GVRSKSGSIC CLALVICFTV
QADLLNMVYV LAAFGFLIVE NPRPAPTVWT HLLVYTCCII ALRYVFQLSI FCTGMTTRGY
FYPSFEPYCT TATAAATNAK SIQPMVLFGL YKFDGIAMDD VTSVYDGLQW DFYVMLFLLW
HQRELRLQGF WVETQSGDID QASSRYKSEV MRGLRTSFSS SHDSIDDAFL YDAPAPGKKL
GARPSFTSQR SSRRFPAIDR APTNASVLSM DNSDIVNEVA AQVLQEMKEQ EKLEAEKKAA
EAALAANSDD NVAHSPSSRR SLEYEASAAN ISPNSPNAAR DNFVSKQVDM DADESEVGFH
ARAKQSWLEK KYPKAHAYFQ TVICKPPAQW DKDIQVAITG EKPGRDFYTA SLSVLLFSSV
YAVIFYEELG EADSSSTSVA DANSRVSSSS LLSGYLVLLV LIELIFIIWD RVAYVTASLQ
SKVILQYSYT LVLHTTVWYF LPSNTNIYFQ QRPALVAFYL FQCVYLWLGA LQIRYGYPAY
LGSRYNYTEE TKVTQASETL FGLMMQAPFL FEMRALLDYM CTKTSLSWQH WVLLEDTAAH
LFGVKGDMKG RVENAEILQG KKRQPMMTKL TSAGVMLLFL LICLVGPLAM FSSINPSTTA
NDVTLTTVVF GIVDEQETMN QLYSNSDSNS PSCKVDLNTD SASVQCVEFD VFSYDVWALS
PPRMDLLVTQ LQSTQVLNWT ISFTFTRPGP TDDEVISTKY SVRITDEHRN ALIPMIKQTV
TDDDSTTLSA IQIDNLFPAV VQLTASSGVL QRSTQMRSVA ITKHASDGST WWTIEPVVSS
SGTNYCSSDY PFCIVAVSDR IVQGLTTLGI SSYGLTAVYI FVVVTVGSAV KGFFRGKLYQ
IQYEELPDPE DVLELVEGIY IARHEHYVGH LKDEVRIFET LVRVLRSPET LIKVTGTNII
HIPTAKEKLD
//
