ID W2QLU4_PHYPN Unreviewed; 5552 AA.
AC W2QLU4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=PDZ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PPTG_07814 {ECO:0000313|EMBL:ETN14157.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN14157.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN14157.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN14157.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; KI669573; ETN14157.1; -; Genomic_DNA.
DR RefSeq; XP_008900426.1; XM_008902178.1.
DR EnsemblProtists; ETN14157; ETN14157; PPTG_07814.
DR GeneID; 20177653; -.
DR VEuPathDB; FungiDB:PPTG_07814; -.
DR OMA; IECDNEV; -.
DR OrthoDB; 71227at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 2.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 4411..4483
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 5416..5529
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 590..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1474..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1895..1929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2103..2135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2171..2197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2359..2410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2506..2529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2660..2718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2945..2987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3823..3842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3977..4000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4241..4314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4374..4410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4515..4534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2103..2120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2362..2410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2506..2525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2945..2972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4282..4307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5552 AA; 615652 MW; AE62DF22C8A3CB48 CRC64;
MFLQRYVHVV LDAILGSYVK NIDPAALQIS IWNGKIEVEA VELQPDAFPL PKQMRLVKGT
LRQLRIDLPW TNLANQPIRV DIQDVSLLLE VCADDRADSD SDETPEKQRR QKLQTLQRKR
AALDAMEKAA EFNEKNKTQT PPGQSWTQSF LFKLMVKVLD NVQVHVQHLH LRMEDAISDP
RHRYAVGMTL EAIIIKSADE GWNYTMVGRG RQQVQDGVSF IRKKMDINKF GIYWSLPLVP
VPATVLNDAE AFATLMRSNF SIGKKLEELE PSPSPPTSEI VETMKMTSPP LFKQSDYIVH
PLTVSMKLTV NDGNAKLPIT HQELSERVLS RLGTPWMVET IDAIGDEAWS EFLEMMPKLA
GERKYTLGFV FSEAWSVARD LTEEEDEIPS VRQFKEALSS CMQWSLEEVG RVEPCIVKYR
EAVVHVMEEK STYIDAQASI DQISTSLHRQ QYLSALSFIS FLTVKRRQAR YLVLRPKRIR
VKDNPRRWWR YAINAVLLDV RERLAHVDWE ALEKKRQQRN RYKELYLVLE HGTTFAATLV
SSDLRSLTKE MARGELDELE FTMDVQELMR LRRAVRKDIA EKEKEKEVLK KLQSQRDNED
GIPISQGSDV PASSRLWSYA SWLTGAGGAH GGHDTGSRRG GEIRVEDVKW SDQDTKDLYD
AIDFHPEEDD KESRSSESGE IEDAAARKKR SLQEHQHILY RFQLTLCKAR FGLSLEDVPT
DLSGLTLHEG IDKAIPTKSS SPSHLIASLD DVEIQFQVRS SCVEVGLQLR DAFFCQSSIP
SVHDNLSRKR RSLSSSGTDF FLQRMDMDEI LEYHPVGVRN QMSSVRLRHC ERELPLMQLH
IESERQPKLD EEADTKREAS TEDAVAGAHL LRVSLVTQPI KCNVNLMFLL DVVAVFSRPI
NVDLSGLEHS AWKRAQSLQR YSTAQLRDAV ARRTKVDMRL DVISPLINII QSPPSDTGIP
TGDEVSLLVF LGHLKAQTKH PGDIIDDTDI TSDLGDDEPA DSRRIAVASP EESLYDVLEI
SISGIEVQII DGGNSGIARN VFRLRTHSSK KSAWHYLLEK TSLTFSFYMS VTPDDPSIPL
LKLFGGVDSV NLNLSATSFR SLMQLLHSFG DNFSAHAQRR IDRDAATVVD IANLPSTRIG
PSTAAPQRSK PKLVRKVSSY VKPGAVALSS SDSSGRPAAS ESSPYLGLAR KIQLERRRTF
GEKDIDDHDL LKLWKRVICQ LQFGVGEVIL TLQVRDMENG SGKIVRVRAV DINTRLKVRS
YDRRLEFALG TFLVEDILLS KPSPSSKVVE KKRFLMKSGN HGVVTDLEDK AEEENIAAKP
PPSSEQLIHV AITSIVSDAV LPKDKKLWKN ARHSPLSPSS FENSIWQDSL ITSLSVDASL
RVLTIDVYQD TLAEVFVFFF QHNNEDTESS VQEQSPPPPP PSLRSISEGS TGKKGNMEEQ
SVLSSVDAEA NERTFSRKLS GWVASSFLEN LGVSPEKEND LSDSTTDAND GTEEELPASM
QLRLHVEGLS MFLHLDDKQR PEGMPSAFAS LTAQQFCCCV QRFPRYLSIF AYLTSLKICD
VSLPDQHLSE IISHGSTSPE PKEDKVWINR DDAREYDDSI AVGHVPTLSE ILVMLDDVPA
VFSCAAQFYG ADSIQEAWHP GYSSRYSVRL KSPRIRFLYS FVDDMRNYWV KGVLLETVLS
ILSRDQADMF WEGDFQLADI QGGPTQAYMN EEMEENLDDA APSGGFLGSD VVSMFPLVDI
RLEDTVLEMP PHRMSSESLL LRFDSFRVSN EGVVNSFLGM ENRIVAKVLL NSSLKQLQLD
MKALRIVSVI LVDRNDVDKR LDGGGFITQS LLGLTNYCLS VDFRSHDDLK LNLSFNPVRL
VCNQEQYAFV LRVPFQNYRE RSRYRFSQGA EVPAKPRARI SSSRSRSVDG ASSSGGIMEV
GDEGSNGMSV SEAEAANDRH IMLDLHVPEI TMEILQGQHG YHPSSSGDLD MVEKGKTIDG
SICLLALSVL SGRADYNLAN GRLTANVDLE GIHMRDSRVK SKMSASYRDV VVFERYKEGL
PKAIKIQFGR ESFDVDVATI GFDPAFTAHG NGLRTPRTQF RSVSSRAIVG LFGSELSLRR
TDSEMSAYSQ MSSTVTSHGA HSEKPSEEKS PPVVGTEGRM DLVVDIAGFK VIPSNIHYDL
IQFLTIPPGL SGDSEGSESS RGDTDVDGDP DPENTVTVPP VYRRISLELN LGPSALLLVE
NPHKLKSRAL MLSWEASIIL NYLQQANEDE CPNIEDKVKE SPTHSRNQLQ FCIALENIHA
TSRLSEESVW AAEQSATAAS ADCLKPIDME TVLQMDLRSR FLRFRTTFNR VMELRFGYLD
FCTMLAALEH IFRRPISVQP SAPGQKRRSM SGSSISSLSG GGADSDTSSW SGRRRSPSSP
RSGLVLSSSK KAERQRTAAL YGSSLIYLVS ASFRGRLETR PVVGFYNSTW RKRYLVLPYT
AQQRQLVESV AFRILPATGS RRQIGDEIYY GDRIILEAVI DNKSDNDEKT AREKSLSKEE
SAETPTSDAA KAAQSTLIRK YDQLGAIGYL GPEGSAGAFE TTIWKHGSTM FNSDKSVIYD
RELIVFEELT IYRSFSKGKK FGVADATGQQ MDFNSARSGP QAEGAHTVDT TGARGGGYLM
FNGVGDAPIP FALSIVSSKP SSRFQQREEQ TSTPVDDGEP DGEAADTVVD ADANTSAADA
GDTVEENQTP PRKKRRTKRK SLFTYSSFLE NLKILEFTLP GVNATVVNDF HNMLLPLLHF
RVATLHADIR GRLEDKFTAL TSLRFGIQAY NSQLAVWEPV LEDFEVNMAY HGKGGVLCDY
CMSERQSISP TGAALRCDGM PLCLFRSSRT EVFTNAAAHS WESKNFIYRE LLEQPDVQDG
AKLANTFMIV VKDDFNINVS RNVINVLVHF FALVTKVTAA DEALSSRLGP FIYVDNQSGI
PFVVATHPSS SSGAPPTAGG TPSSSRRPTS SIEMPTEVPG ADTNDDIMKT GTAMFNSNAW
SRRRLTTMLN DISSSDTKWI RVESGERVAT EIVAHEAPAG CVTSPLRRLL WLKPQSPTQR
TTSSKAIPVP IGYSNRSYLH LESSGKQRDS WHGESIICET VAEQGTLVLR LRGKIQLANF
FSVPIQVIYN DQREETIEPG GKTAHYIPIQ YLESGTIAFR PLLSNGKVQH SEPLSIASLL
RSNDSKYRGR SNRRQNVGSL ELRKALTFYW DVHPSSGSED APDFSFGVSL PPFQVILTAL
RKSERHETTI TLRPPIVLEN LVPYELSYRT VCMKSEAEVV WVAKNAASFS GVNGKVSSGS
SACIAELDVL ERDMENREVV QTPTVVGLSL ALPQIQLGRF SRWSRDTFIY GCQSFCERIE
LNMRDDSELE APTPANKLTI CVEITQLEKL RSRALNTLCP VVCRVFTEYW LIDRTSLSLA
FYTADDYLIP SNHPGRLYDD KSDAENESSS VSLSVFSCES KQVVSKMKIG IKGETGEREV
QSEPFDISAV GVRGQILVPT NRSRDARSLL STITEFGAPS NGLRTTFKQY EFGVMIEQGP
EKFSRSRVVT LVPRYYFINT SNRFEIRVRQ ERSTDASAVI VLRPQETKIF HWSDSRLPSR
VQICFVLPDN RHDDRDTVSF ANSSQWSAPF ELSSVGNFVL RVKSKVRPAP PCLPECFEGN
VAKREQIEDD DEADMFFDEE DEYSDAERML ANGTQLNVAV ELHDPSFLVY LEEGKQSIHS
SPLSSYEYEE DDREHTLTVK HKENEEFVPF KIKNECSNLA LVVWQKTLIK DDKGNVTIGF
EGGEPVLPFH TIDYVPFRFS AFPTVFVQVQ KVAGLGIGAL RKEHPLHGHR SNTKTSADRK
GKDPPITALT RAAIVGQTQV VASFEVQLKK LQRLPTIDVS EGVVKKRLWA EVLLDETTKT
LLVTDMLPGF SGEHKRRRRA TLLRSWKRYN TSIVFISHVL AAHRAQLMDG SEEDNAHDVP
AKKKRVRFAS DVVEMKGKSG ADEAGSSEAQ QGAEASSIPP AIEEEKEIEA LVLCVRLVEA
MCLEDVFLQA GRSDLTSCQP FITFSLKSDG EEARTKLVPQ STTMFPRWLP APNSRAVLSA
LMLSDGGEES SSYEFGAGAE IIVEIREADK ILFGSSVIAT ARIPLQEYCA AAMISARGGA
NNELQVVEFL APVRVARKGG GWSHPVENEA RIRFQMCCRR TLTTRSAAAE SSGEGRDSLE
TVKELKDILS AYNMKKELDV LVSSKSQLKL LLEREAVDTS TSGTNIPAAL RSVPDASSGE
EKKDSGLLQF VARPAGSDDD SVGARSRSSS SARGSAVSAT TDESTSDGTY EEMGDEKRLS
AVLIGVSNLQ IPTEIIRNNF KHAHGTTDHL EPKVYCTITY QESTRSALSA VAKPSSVSAA
TDQNIPDDNG SSSPDRSSMT GPPGSNDHLQ QVRTHEFPRG QMLGLDLVYR NGRVLVQGVV
CDGPCGALVY EGKIRIGDTV VAANNKSIVN LHRDASFAVI EKAMHWGEGV GTPTPEQASA
TFTLSFLYQP TTPERMRFSD TSRPPCAQAT DDDTGVRKYD AEWNRRVEFV ETANKKPAAG
SGEDQVLVRV YLRNETSDHG LSASQESSIV PFLYFFGDDA MMDHLDHSKQ DSRFDVLLAE
CWVPLPPSSL SSAANPMSMD GNPMAEPSAL TFNERICALY SPQQRTHQHS ALEMIGQLRL
ALKWDFINPL RAAHQQGDLS LHFQLEVARI CISVVDDGAW SSVTSAAGPQ QPQEVLCISL
SDQNASAGVQ LSYGQITDGK QVINARFGHF QIDNQLLDTN YPVLLRPMRL VDAQMQEEGY
TMSREKGGKN NDADSPMLLP TVQLMAVFSR QPNVIQFDYI FGQLQELEIK LEDATLVALA
HVFSGVEWSH TASNTRTSKK KKRPGDEFGS NLALKLLEIE WSTPTLLSTA AGGRLGSTRD
GGGANMKVLL RWLLLCPVKV NVTFTSTADR SLLLSLLSPD MSSVLSTLIS AAAALVSNLD
QAPIRIPEFY VENLLETTHT LAFYAMQHYL HHGLRSWYSI MGSVDFLGNP IGLVSTLGTG
VKDFFYTPAQ MLLEDENGLR IDNLRTGMTK GSKSLLRNTA VGIFHTTGKI TETLGKGIAL
LAMDEQYNVQ RQRASTRQIK KINDLGDAIA EGSKGLVGGV WDGIKGVVAA PVRGAEQDGA
GGFVVGIGKG VAGLIVKPTA GFLDLLTSLS RGAKTSAESL DGTDRNAFDT VTRFRLPRRI
CSDGVLVSYS DREARGYAVL LLTSLDATDD YVYHVDYGIE PHRGLLLLTD KRLICLSGKT
GQKLWEVALD STLEVVVEGA TLKIGQTTSP SRSYNIECDN EVAATNFRVA VDSARVDVSA
TRYLLLNLEK SQEESRIIGG GRFGSGAAGL MNNDEDRTDL HVLMESVQDT TVSGLSNDDL
RSQPLRSVRV EVCHLQNKDA HANVPNRAID KLLSFSVFQI QVYGGPYQWT VFRRFSEFRE
LCATLESAGY VLEGLPPLPP RTFLPSTRAP VAKYRQEALN MFLQAAIMHS AISRSAAMLN
FLTCAAREVR VSLPPLSPTG EREASQRAGD SP
//
