ID W2QMF0_PHYPN Unreviewed; 2628 AA.
AC W2QMF0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=PPTG_08439 {ECO:0000313|EMBL:ETN13694.1};
OS Phytophthora parasitica (strain INRA-310).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=761204 {ECO:0000313|EMBL:ETN13694.1, ECO:0000313|Proteomes:UP000018817};
RN [1] {ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN13694.1, ECO:0000313|Proteomes:UP000018817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=INRA-310 {ECO:0000313|EMBL:ETN13694.1,
RC ECO:0000313|Proteomes:UP000018817};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Arredondo F., Hong C., Coffey M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Phytophthora parasitica INRA-310.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI669574; ETN13694.1; -; Genomic_DNA.
DR RefSeq; XP_008900770.1; XM_008902522.1.
DR STRING; 761204.W2QMF0; -.
DR EnsemblProtists; ETN13694; ETN13694; PPTG_08439.
DR GeneID; 20178243; -.
DR VEuPathDB; FungiDB:PPTG_08439; -.
DR OMA; WYQARRI; -.
DR OrthoDB; 48945at2759; -.
DR Proteomes; UP000018817; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF150; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00211; Guanylate_cyc; 3.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018817};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 405..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1187..1208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1220..1239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1267..1289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1309..1326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1338..1363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1383..1406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1573..1591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1597..1615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1627..1645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1657..1680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1701..1723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2105..2126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2146..2166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2203..2222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2242..2262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1774..1903
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 2310..2525
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 573..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2584..2628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2628 AA; 293935 MW; 09409BD14440F92B CRC64;
MALPLPQNAI RSGRSSFPGD VALVSQKVDA TSSANTVITS QSKKRHNKFD LLTSLLRRNR
VIDNTSEPSD NTQELIKSRL LFVNDVKRTM EYATYMQKFH HADPYSANTV RSSKYSALNF
LPKSLFEQFR RVANFYFLII SLLQLCTDLS PTNEYSTIGP LMLVLTATMI KEGLEDRARH
QQDWVVNHGK VETLDGMVEP GKKLKSAGDI SRTNHLGDFQ SIFWKNVRVG HVIKIHDQEQ
VPADMVLLFS SQETGEAMCE TSSLDGESNL KVRHCIKWNH IIPHTPKEFG DSVHAEIRCE
APNKRLYSFD GVMRISRSKT QAIGEPPRSY LEARSLENGD EENAPEAEEI PITIENVLLR
GMKLCNTKWA IGVVVGGGND TKLVQNMKSI PSKFSRLDRI ANRCIFLIFS VLFGVCCFSS
IQASLFVVKV HRKPGYASAY PFIAKFHPAY VLEAWVTYLI LYNNMVPISL YISLEVVKWY
QARRIENDPK MYCPTTGRGV TARTSNVNED LGQIKYIFSD KTGTLTKNQM LFKVCSIGGI
IFDGSNMQHR RAAQAGSDDL SIGSDMMLKF GSASTVRGSS TGREGSADGR RKSKHVSVTE
KDVRSYSQMM KFVENPSRFS GKELHAVELA RPFFRCLLLC HSASVAIEDP SGHADAHSTA
SRTPTESSIR TESRRHSAGY NSFTSNLAAA EATDAFPSLI KGDHKFFGSS PDEVALLNAA
LEFDCVYERR DGDVIHIRLF GIPESYQLLA LNEFDSTRKC MSVVVKRLNR DDCHDSKLAR
VQDNLGDLEH TDLDGLINES ESEEQDILVF SKGADTVMFA NASKDQDINK LALHVHYFAA
MALRTLLLGY RTLSMAEYME WKSEFDLAKK ALSNREQLCV EVARKIEKST KLLGATGVED
LLQDGVRECI SQLSLGGINI WMLTGDKDET AISVAHMCGL IGPKSKIIII KGKTKQDCLD
EIAKARRKLK REGVWVPGVA SQDISLVING EALELLLADA LTSSKIKSQI SYINGNQTSP
NAEPHSATID ALRSERDTRF SGSMSAKSMG NLPFPATPNS RHRSSSRPGS TRSSITDTNG
NVQLAHELFL ELASQCRTVV ACRLSPMQKA QVVSLMKAAP GTPLTLAVGD GGNDVSMIQE
AHVGIGIYGH EGMQAVRAAD FAIATFRHLS RLLLVHGRWN HRRVARVILF SFYKNMALIM
TLFLYSFYNG YSGQTLYESY LMVGWNVLYT VLPIFVLGIT DEDIRDSAVL RFPFVYRSSL
RKSELSIRIL SFWVANALFH SLLVFYFVMK TMGGVSSKHS HTNGLFPDGT AVYGALIITV
TLKASLHTQC LYRWTRAHYI SLVGGFLAYI LFVGAYSQAY RMFPTFDVFR DFQGLAHILF
SEMLYWAMLF YTSVTCLCVD LAVMYLRKMY LPSSNDIILE IDSGLGDIPS LPVRNADGSI
DNSRAAKLIY SSSGRSEEGS YSGASSAVGG STKGELTPSL LEGEWSQQFR DFDLPTEHDE
LSKQLVSIQR ELAQEIGHPD PLTQEDDAHS SRALRVQPPV HPLTLEFMGE EHQRLEMEYE
ITFAFRERSR VMLCLKVMAF MVPLYAAYEL LWERESSYIY IRVGYFVCDV LFMRFARTKY
FVQYYQIAIL LPYCMSGMAL TLTISDTGKF AAALYPVVLF VVIRVKFLYA LMLSIYNFAF
YMLADRLSSM NYNNSVDLTD LMLFALYLVF VITFGAYACY SLQITMRRDF LQSRSLLIEQ
KRSTQILKNM LPEHVVQRMQ KGDTNISEDE QDVTILFCDI ADFASFVNRF SPTEVVSLLD
RVYSLFDQIC QKHGVRKMET VGKTYMACAG LQGKDHGREA ALRAVSMALD MLACLDKCRA
SNGSGIKLRI GVHSGRVVSG LVGMKKQQFS LFGDTVNTAS RMQSTGVTGR CQISQITYKK
LVGHFTFEER QIDVKGKGTM TTYLVGEPLT EVAQLSCLGQ LEFSSKRDSV MMSSSIINVR
RAFEQDFLAA TRNKILHSAR QRWKKYDPIR MLLGTPPDLA SWGGTDTSES VEQHMLTEIR
LLNMCFKDDD MENKYLESTL SNRVEGARTT LLALAAYASF TCMRDLLVEV FSVISAYAPQ
KEISATMYAI LLFIRSPFVI VAILVARRVR DEFVFYSETK LRNVLLGFYL VGLFVFTLTQ
ALLWGLNYEA DLDTSPRYVN LCLDTVLAMF VVSNGRSILY RHVVVFNVIA LFMVSITTLV
SLQRYHQDAA KFNSKFKTSY PIVLTYFSVV ANIIASQSVE FFTRRQIWLK TRTQLETMNA
DRLLYQMLPA AVVMRLKEGE MVCDQHQQVG ILFSDIKGFT SIASQAATAQ VVNILASLFC
AFDKLTEKHG VFKMQTIGDA YVIVSGLPYV DMSLGPGVVT SSASTADMSI ADVGSTSTPS
IAGIASGFMR ISSNRVLPLE RKTEVMEGQN GSPRGSGSKL RSHLLRRSTL KHKHQMHLRS
HIRDLLAMAR DMHKEVRKVQ DPNTGERLQM RIGIHIGNII GGVIGTTTLR YDMWGPDALT
ANELESNGVP EKILVSPVVQ EVVKDMIDIR CTFHRKINFT NVPMMDTYLV EFIEPDGTGG
RASGCIAGSN VRENSGIPPE QLNPAPGYVG SDDDTTRPQS PREHTTPN
//
