ID   W2RQM2_9EURO            Unreviewed;       389 AA.
AC   W2RQM2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=GPI-anchor transamidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1541_07631 {ECO:0000313|EMBL:ETN38008.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN38008.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN38008.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN38008.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
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DR   EMBL; KB822723; ETN38008.1; -; Genomic_DNA.
DR   RefSeq; XP_008720177.1; XM_008721955.1.
DR   AlphaFoldDB; W2RQM2; -.
DR   STRING; 1220924.W2RQM2; -.
DR   GeneID; 19974970; -.
DR   VEuPathDB; FungiDB:HMPREF1541_07631; -.
DR   eggNOG; KOG1349; Eukaryota.
DR   HOGENOM; CLU_044656_2_2_1; -.
DR   InParanoid; W2RQM2; -.
DR   OrthoDB; 1122658at2759; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:InterPro.
DR   GO; GO:0003923; F:GPI-anchor transamidase activity; IEA:InterPro.
DR   GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR028361; GPI_transamidase.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR48067; GPI-ANCHOR TRANSAMIDASE; 1.
DR   PANTHER; PTHR48067:SF1; GPI-ANCHOR TRANSAMIDASE; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
DR   PIRSF; PIRSF500138; GPI8; 1.
DR   PIRSF; PIRSF019663; Legumain; 1.
DR   PRINTS; PR00776; HEMOGLOBNASE.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..389
FT                   /note="GPI-anchor transamidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5027877210"
FT   COILED          302..336
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   ACT_SITE        142
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT   ACT_SITE        184
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ   SEQUENCE   389 AA;  43951 MW;  FF6267FD93EB26C3 CRC64;
     MRLLGWLAPL AIFSLTHAAH TSNWAVLVST SRFWFNYRHL ANTLSLYRTV KRLGIPDSQI
     ILMLPDDMAC NPRNAFSGTV YSNSDRRMDL YGENVEVDYR GYEVTVENFI RLLTDRWEHG
     VPASKRLQTD EGSNILIYMT GHGGSEFLKF QDSEEISSWD LADAFAQMQQ KKRYNEMLFM
     IDTCQANTMF RHFYSPGVVA TGSSEEDESS YSHHADNDVG VAVIDRWTYY VLEFLETHVT
     SPTSDKTLGD LFDSYDVKKI HSNPGVRWDL FPGAEAAGRN RRVVDFFGNV QSVELQGNQT
     KSAALQSDLA GLMKLVQEYQ QQAAAQESNK TEMAQTLAQR GVKTTTKKPQ QTTINRMSVT
     ESNKWVRQVG GATVLSGLAA LWYFAPKLV
//