ID   W2RRG6_9EURO            Unreviewed;       852 AA.
AC   W2RRG6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=alpha-glucosidase {ECO:0000256|ARBA:ARBA00012741};
DE            EC=3.2.1.20 {ECO:0000256|ARBA:ARBA00012741};
GN   ORFNames=HMPREF1541_05338 {ECO:0000313|EMBL:ETN39116.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN39116.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN39116.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN39116.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-
CC         glucose residues with release of alpha-D-glucose.; EC=3.2.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001657};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC       {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR   EMBL; KB822721; ETN39116.1; -; Genomic_DNA.
DR   RefSeq; XP_008717901.1; XM_008719679.1.
DR   AlphaFoldDB; W2RRG6; -.
DR   STRING; 1220924.W2RRG6; -.
DR   GeneID; 19972677; -.
DR   VEuPathDB; FungiDB:HMPREF1541_05338; -.
DR   eggNOG; KOG1066; Eukaryota.
DR   HOGENOM; CLU_005043_1_0_1; -.
DR   InParanoid; W2RRG6; -.
DR   OrthoDB; 5486960at2759; -.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06595; GH31_u1; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR   InterPro; IPR048395; Glyco_hydro_31_C.
DR   InterPro; IPR000322; Glyco_hydro_31_TIM.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR   PANTHER; PTHR22762:SF89; ALPHA-XYLOSIDASE; 1.
DR   Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR   Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|RuleBase:RU361185};
KW   Hydrolase {ECO:0000256|RuleBase:RU361185};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT   DOMAIN          217..532
FT                   /note="Glycoside hydrolase family 31 TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01055"
FT   DOMAIN          543..636
FT                   /note="Glycosyl hydrolase family 31 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF21365"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   852 AA;  95115 MW;  A47394C7F5E72FDA CRC64;
     MAPSSSPIEP NPNAHPSNII TAPGQNYRFT LLTPQLLRFE WSPSGAFEDR ASTFALHRGA
     FAPVAHRIKD NAPGAPGGTG QGGFEILTEF MHVDYDGKEF SPSGLVVDVK GRTTLWGTQW
     RYGSEEKVGA GRKGNLGGTA RTLDEVDGRC DVDVGVCSRL GFAVIDDSGT MLFDPASDWV
     AGRPGREAGY VDGYLFAYGR DYRAAVRDFY RLSGPQPVVP RWALGNWWSR YYRYSDTEYL
     ALMDAFAARN IPLSVAVIDM DWHYTYDERV PHAGWTGYTW DHSIFPDPAG FGKEIHKRKL
     KMSLNDHPHS GVHHHEESYE AMAKVLGHDT SEKNPILFDP TSKKFMDAFN GVLHRELERK
     GCDFWWIDWQ QGRFSRVPGI DPLWVLNHFC FEDNRNVASA SDSASKEGQQ QQPMIFSRYG
     GPGSHRYPVG FSGDTVTTWA SLQFQPEFTA TASNIGYGWW SHDIGGHMFG VRDDELVTRW
     VQLGVLSPIM RLHSTNSRWM GKEPWRYRPE SEKAVEAWMR WRHRLLPYLY SLDVRAARPG
     GEGMPLVQPL YWHFAELDEA YAVPNEYFFG SELLVAPIVT PRDGRTGLAS VKAWLPPRMG
     RFVDIFTGVI YDGDRELTLY RGLGEVPVLA HEGSVVPLDG ERVPGNGAEN PQRFEVLVVV
     GRDGEFELVE DQGDDGEGLK KEAEEKRGEE GAVERKSFVS WKQQDGKLTA NVAGRTWSFR
     FLGVTEVPSG LKILVDGKDV TSDANVAVQA YPEAPGLLIE CSPGLGFAKY DIAVEFGVAD
     PQLSVRDHRQ KVEEMLLSYQ VEFALKDKIW KIVEGKTPGN VKVGQVLALG LDEVLAGPVV
     ELLVSDIRGW GA
//