ID W2RW53_9EURO Unreviewed; 353 AA.
AC W2RW53;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Glycoside hydrolase family 43 protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1541_04827 {ECO:0000313|EMBL:ETN40550.1};
OS Cyphellophora europaea CBS 101466.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN40550.1, ECO:0000313|Proteomes:UP000030752};
RN [1] {ECO:0000313|EMBL:ETN40550.1, ECO:0000313|Proteomes:UP000030752}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN40550.1,
RC ECO:0000313|Proteomes:UP000030752};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phialophora europaea CBS 101466.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
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DR EMBL; KB822720; ETN40550.1; -; Genomic_DNA.
DR RefSeq; XP_008717393.1; XM_008719171.1.
DR AlphaFoldDB; W2RW53; -.
DR STRING; 1220924.W2RW53; -.
DR GeneID; 19972166; -.
DR VEuPathDB; FungiDB:HMPREF1541_04827; -.
DR eggNOG; ENOG502S9PF; Eukaryota.
DR HOGENOM; CLU_009397_8_0_1; -.
DR InParanoid; W2RW53; -.
DR OrthoDB; 1435052at2759; -.
DR Proteomes; UP000030752; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd08999; GH43_ABN-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF5; ENDO-ARABINASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT ACT_SITE 49
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 236
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 165
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 353 AA; 36472 MW; 009E470A27C36E9A CRC64;
MVAIPTYLLA ASAASQIKSR SPEPAVESQD SAGFYGSVIG PVVGGNFPDP AVIYDAGTSY
AYSTNSAGVH IPMASSQDNA SWSVMTGHDA LPSLGPWETD GQIWAPDVIR TDSGFVLYYA
AATKASNGQY HCIGVATSED PTGPFAPQDQ PLICPDGPST GGAIDPDGFQ DSDGKRYIAY
KLDGNANGNG GNCNNGIAPF QNTPIMLQEV DQDGVTLIGG PTQILDRDEA DGPLVEAPSL
HRSDEGIYFL FFASNCFSSP QYATSYATAT SVGGPYTKAA RPLLVTGDGP DVYGPGGLDI
MAGGNLVSFH GILGQSASPA RADVGGTQGP LVRGMYTGQM TFGGREVSFQ VSS
//
