ID   W2RZE0_9EURO            Unreviewed;       329 AA.
AC   W2RZE0;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN   ORFNames=HMPREF1541_03636 {ECO:0000313|EMBL:ETN41700.1};
OS   Cyphellophora europaea CBS 101466.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Cyphellophoraceae; Cyphellophora.
OX   NCBI_TaxID=1220924 {ECO:0000313|EMBL:ETN41700.1, ECO:0000313|Proteomes:UP000030752};
RN   [1] {ECO:0000313|EMBL:ETN41700.1, ECO:0000313|Proteomes:UP000030752}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 101466 {ECO:0000313|EMBL:ETN41700.1,
RC   ECO:0000313|Proteomes:UP000030752};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phialophora europaea CBS 101466.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000256|ARBA:ARBA00038157}.
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DR   EMBL; KB822719; ETN41700.1; -; Genomic_DNA.
DR   RefSeq; XP_008716209.1; XM_008717987.1.
DR   AlphaFoldDB; W2RZE0; -.
DR   STRING; 1220924.W2RZE0; -.
DR   GeneID; 19970975; -.
DR   VEuPathDB; FungiDB:HMPREF1541_03636; -.
DR   eggNOG; ENOG502SI2J; Eukaryota.
DR   HOGENOM; CLU_023205_1_1_1; -.
DR   InParanoid; W2RZE0; -.
DR   OrthoDB; 1379250at2759; -.
DR   Proteomes; UP000030752; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd19075; AKR_AKR7A1-5; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43364:SF4; NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030752}.
FT   DOMAIN          5..305
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
SQ   SEQUENCE   329 AA;  35846 MW;  95BA9F07EC5F4957 CRC64;
     MPSVKVVFGA HAIGDPADPL TGFATPEAAQ SALNICRKHG CTIIDSARGH PPHVPHTSEP
     LLGQTDVATW ATIDSKVDSV YPGDHSADRI AASIDAILKD LNVPSVNVLY LHIPDRSVPL
     KETLQALDTA HKAGKFKELG ISNYEPDEVL DILHLCRTNN YLPPTVYQGQ YNAIVRSITP
     TLLPILRAHN IRLYAWSPGC AGFFHRGARH RHTSNSRIGQ ALSSIYSKPS FTHALENFHA
     AADRAGGVEG HEVALRWLRF HSELSGEAGD GIVFGARTEA QVEGSLTALE KGPLSEELVA
     AVERCFEEVK GDVPYFNPFR DDEKAWARS
//