ID W2SG99_NECAM Unreviewed; 340 AA.
AC W2SG99;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Fz domain protein {ECO:0000313|EMBL:ETN68573.1};
GN ORFNames=NECAME_05537 {ECO:0000313|EMBL:ETN68573.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN68573.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; KI669240; ETN68573.1; -; Genomic_DNA.
DR RefSeq; XP_013290800.1; XM_013435346.1.
DR AlphaFoldDB; W2SG99; -.
DR STRING; 51031.W2SG99; -.
DR EnsemblMetazoa; NECAME_05537; NECAME_05537; NECAME_05537.
DR GeneID; 25345569; -.
DR KEGG; nai:NECAME_05537; -.
DR CTD; 25345569; -.
DR OMA; DTIMEHF; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF148; SECRETED FRIZZLED-RELATED PROTEIN 1; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..340
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004824318"
FT DOMAIN 35..158
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 195..311
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 90..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 121..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 340 AA; 38802 MW; B43077936C523547 CRC64;
MSRVSLLLAA LLLTTNSAYL SDSWMLSSER PVGPRCVPIP HNLTICYGMQ VDSDIFQYTQ
MRLPNLLEHE TINEAIHQSS DWKSLLQLNC HPDTQLFLCS LFAPICLPTM DKEILPCRSL
CQAVKQGCEG RMSVYGFPWP EMLSCDKYPE DNDMCIKAMN TEKQGKLARP MHGEKSNVRV
STEELHHFAA RDISCPACSQ VGTYENLVDH FCRSQLVVKA RVDAVSGTHI SLRNARSLKK
GDRRRSIDDT DVRLSSDSSE CPCNVTDGVE RRFLVMASKN NDGQLVANLI LPWKKEKGFK
RAIHQFQRLN CKSLGREIRE SASRRPHYYS MRRHNQRRLL
//
