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Database: UniProt
Entry: W2SIB7_NECAM
LinkDB: W2SIB7_NECAM
Original site: W2SIB7_NECAM 
ID   W2SIB7_NECAM            Unreviewed;       435 AA.
AC   W2SIB7;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-SEP-2017, entry version 14.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=NECAME_15715 {ECO:0000313|EMBL:ETN68626.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN68626.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K.,
RA   Martin J., Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V.,
RA   Minx P., Warren W.C., Wang Q., Zhan B., Hotez P.J., Sternberg P.W.,
RA   Dougall A., Gaze S.T., Mulvenna J., Sotillo J., Ranganathan S.,
RA   Rabelo E.M., Wilson R.K., Felgner P.L., Bethony J., Hawdon J.M.,
RA   Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KI669228; ETN68626.1; -; Genomic_DNA.
DR   RefSeq; XP_013290853.1; XM_013435399.1.
DR   GeneID; 25355741; -.
DR   KEGG; nai:NECAME_15715; -.
DR   CTD; 25355741; -.
DR   KO; K02154; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053676};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    236    257       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    355    384       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   435 AA;  48834 MW;  1B4B33A65DC12EDC CRC64;
     MFSQISNFAG VGVKLAKLLF VEVYKVSFLL QQDTFTKSIT SGGHISGQND VPLTPLLNDE
     KGENAWFVAG VIPLDKKNTF ERVLWRACRR TAFVRISDIT LTLEDPVTLA PIMKCVFIVF
     FKGESLKLII DKKASGCDVS PILNEMARQT APPTFHRTNK FTSVFQSIVD SYGVASYREI
     NPGSYCAPSL LIGLINMFML KERPVGYMLE NNSTAHHPTC YLNQWYPEQA FVEKCLIFTA
     LGCIPVMLLG RPLAAYLDQK KMAGRRKFLN GILADDSEHL IAIDRYLHEH SLADAFVNQA
     IHTIEFVLGC VSHTASYLRL WALSLAHAQL SEVLWHMVLI PGISSEGNIL TTSAATYVVF
     FFFAIMSLSI LVMMEGLSAF LHALRLHWVE FQSKFYQGAG HPFRPYSLQE CLETAQHLSE
     VTEDHTQCSE VTDEL
//
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