ID W2SJE5_NECAM Unreviewed; 130 AA.
AC W2SJE5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Low-density lipoprotein receptor domain class A {ECO:0000313|EMBL:ETN69725.1};
GN ORFNames=NECAME_15147 {ECO:0000313|EMBL:ETN69725.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN69725.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KI669059; ETN69725.1; -; Genomic_DNA.
DR RefSeq; XP_013291952.1; XM_013436498.1.
DR AlphaFoldDB; W2SJE5; -.
DR STRING; 51031.W2SJE5; -.
DR EnsemblMetazoa; NECAME_15147; NECAME_15147; NECAME_15147.
DR GeneID; 25355174; -.
DR KEGG; nai:NECAME_15147; -.
DR CTD; 25355174; -.
DR OrthoDB; 4337612at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Lipoprotein {ECO:0000313|EMBL:ETN69725.1};
KW Receptor {ECO:0000313|EMBL:ETN69725.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DISULFID 23..35
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 30..48
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 42..57
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 130 AA; 14481 MW; 9B0BF9487A6C9636 CRC64;
MGVDATFELR VSEDAVKPAS VGCPKNERMC RSGHCLPVSQ FCDRIVQCPD GDDEQNCTTI
KCSSSEFRCE STNSCVPDVV RCDGWKDCHD GSDEASSFHF HAKLRVDITE EDEQEKRPSG
IRAFVTINNM
//
