ID W2SR04_NECAM Unreviewed; 1705 AA.
AC W2SR04;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Transporter, cation channel family protein {ECO:0000313|EMBL:ETN72174.1};
GN ORFNames=NECAME_13952 {ECO:0000313|EMBL:ETN72174.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN72174.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI665384; ETN72174.1; -; Genomic_DNA.
DR RefSeq; XP_013294401.1; XM_013438947.1.
DR STRING; 51031.W2SR04; -.
DR EnsemblMetazoa; NECAME_13952; NECAME_13952; NECAME_13952.
DR GeneID; 25353980; -.
DR KEGG; nai:NECAME_13952; -.
DR CTD; 25353980; -.
DR OMA; TLFIAWN; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 203..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 906..928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1020..1046
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1173..1193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1205..1222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1243..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1338..1364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..353
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 406..630
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 750..1050
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1104..1375
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1620..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1651..1666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1705 AA; 197409 MW; A3292286A3614034 CRC64;
MLTRRKSSLP SDGKTDGGSG GQRKRRGESV VALTEIINLE PSAINKKPSE ILQNDVLKEL
VRLACLLSMI SVCLHTPETI QLWPPLNYAI FANDCIVTLV FLVEAAINIH HVGLWENESS
YLRAKWSQFD LFMLLMHVLS CALHCYELFT ILVPSIGLVY RPWFGVIRSP RPFIMLRFIR
SLVRFKLPKN RIKQIIKRSS QQIQNVTIFF MFFMALYAIM GVQLFGRMDY HCVLSGTDPR
NVTIADLAIP DTMCSQKGEG GYECPDNMVC MKLDMSAHVE GFYGMFNDFA SSLFTVYMAA
SQEGWVYVLY DCLDTLPSYV AFFYFVTLIF FLAWLVKNVF IAVITETFAE IRVQFSEMWQ
SNTSASEETY TQRLERFEDG WRLVEIDHYS RGTNSPQFLH LLVNSTAFQI AMMVLVLLNA
LINASFVYRH DNSDIVRKEI YYYVEICFTI IFNLEALIKV IGYGWKGYLR RGQHKFELIL
CVGSTLNLIR PLYSMNIFTY FQVFRIVRLI KASPMLEDFV YKIFGPGKKL GGLVVFTMVL
LFITSAISLQ LFCYVPNLKK FTTFPMAFMS MFQIITQEGW TDVVVEILRA TNESMVPFVA
IYFVGYHLLV TLIVLSLFVA VILDNLEMDE ELKKVKQLKA REQNTIKTTL PWRLRVFDRF
PTRPQMISLR KMTSEFPLPK IRDSFTRQFA DENERNNTDA NEADASNSRS ILRRGANIRA
QWKVRMRHIG QNSSRHILTS LLDDFIGLMT YLDWAMVFVT SLSCWSMLFE SPWPTNGENL
IFNNPYLQIT EYLYVASMTF ELVVKVIANG LFFTPKAVVK DVGDIMTFFI YFIARHTDKI
EFSRNSLKLH LQTSVIYLLW MPSHVEINSW AQMLMIMRAM RPLRIYTLVP HIRRVVVELC
RGFKEILLVT VLLIVLMFIF ASFGVQIVGG KLAACNDPTI TERENCTGVF EQKIFVTRME
VYGKNDDKLH PKILVPRVWT NPRNFNFDHI GNAMLALFET LSYKGWNVIR DILYLRQGPW
AVLFIHIYVF IGCMIGLTLF VGVVVANYTE NRGTALLTVD QRRWHDLKAR LKMAQPLHVP
PKPPESAKLR SYLYDLTLSR GFKQSFAILV VINSFTLVVP WNVEEEKQRR NFLFGLTILS
AFCNILFTIE IILKSVAFTV RGFWQSRRNR GDFLITILGL TWIVFHFLFQ VPAYIAGGIN
EWKRLTYTFG YMVVILRFFT IAGRKSTLKM LMLTVLMSMV RSLFIIAAMF LLVLFYAYTG
VILFGMVKYG QAVSKKIIDY SNENSREIRS EIFSFFSQKL NFLRESLNSE ERQRPVRSPP
FCYWAEGLNY WETDCGNYFG AIVYFCSFYL IITYIVLNLL VAIIMENFSL FYSSEEDALL
SYADIRNFQQ VWNIVDADQK RSIPTRRVKF LLRLLRGRLE VDPNKDRLLF KHMCYEMERL
HNGEDVSFHD VLNMLSYRSV DIRKSLQLEE LLQREELEYL IEEEVAKQTI RAWLEQCLRR
IKQKQNVVGP TVIVSGALEI TVNIFQQNQP ETVVPTSLAL HRLSCLIPLV PHVPSQLNLQ
TTLTTPQTTA PNFESFDSRE SGDEDGGSRK KQRRRNSIPE LVGEAKKFMF GSLAKRLEKA
AESKSGKDRR GTLKQLQMPT YELPDLEENL DEASDSPHER RHSVDTPLSN NPDLLIMNTS
TPSVEFQAIE PNPDLQQWWT DLFEL
//
