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Database: UniProt
Entry: W2SS74_NECAM
LinkDB: W2SS74_NECAM
Original site: W2SS74_NECAM 
ID   W2SS74_NECAM            Unreviewed;       113 AA.
AC   W2SS74;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-SEP-2017, entry version 14.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
DE   Flags: Fragment;
GN   ORFNames=NECAME_14122 {ECO:0000313|EMBL:ETN71696.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Ancylostomatoidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN71696.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K.,
RA   Martin J., Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V.,
RA   Minx P., Warren W.C., Wang Q., Zhan B., Hotez P.J., Sternberg P.W.,
RA   Dougall A., Gaze S.T., Mulvenna J., Sotillo J., Ranganathan S.,
RA   Rabelo E.M., Wilson R.K., Felgner P.L., Bethony J., Hawdon J.M.,
RA   Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KI667198; ETN71696.1; -; Genomic_DNA.
DR   RefSeq; XP_013293923.1; XM_013438469.1.
DR   GeneID; 25354149; -.
DR   KEGG; nai:NECAME_14122; -.
DR   CTD; 25354149; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053676};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM      6     23       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   NON_TER     113    113       {ECO:0000313|EMBL:ETN71696.1}.
SQ   SEQUENCE   113 AA;  12918 MW;  A696F63CD3FBF161 CRC64;
     MFFGGRYIIL LMGIFSIHAG LLYNDLFAKS FNIFGTSWLN PYSRDELMTW INQSEVAHKE
     MLLEINPGYS YQHAEGPYLY GMDPIWNIAG NKLNFLNSLK MKLSVIAGIA QMT
//
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