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Database: UniProt
Entry: W2STE0_NECAM
LinkDB: W2STE0_NECAM
Original site: W2STE0_NECAM 
ID   W2STE0_NECAM            Unreviewed;       663 AA.
AC   W2STE0;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=L-lactate dehydrogenase {ECO:0000256|ARBA:ARBA00012967, ECO:0000256|RuleBase:RU000496};
DE            EC=1.1.1.27 {ECO:0000256|ARBA:ARBA00012967, ECO:0000256|RuleBase:RU000496};
GN   ORFNames=NECAME_14040 {ECO:0000313|EMBL:ETN71967.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN71967.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC         Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC         Evidence={ECO:0000256|RuleBase:RU000496};
CC   -!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate
CC       from pyruvate: step 1/1. {ECO:0000256|ARBA:ARBA00004843,
CC       ECO:0000256|RuleBase:RU000496}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CC       {ECO:0000256|ARBA:ARBA00006054}.
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DR   EMBL; KI666148; ETN71967.1; -; Genomic_DNA.
DR   RefSeq; XP_013294194.1; XM_013438740.1.
DR   AlphaFoldDB; W2STE0; -.
DR   STRING; 51031.W2STE0; -.
DR   EnsemblMetazoa; NECAME_14040; NECAME_14040; NECAME_14040.
DR   GeneID; 25354067; -.
DR   KEGG; nai:NECAME_14040; -.
DR   CTD; 25354067; -.
DR   OMA; YTCWGIG; -.
DR   OrthoDB; 5344346at2759; -.
DR   UniPathway; UPA00554; UER00611.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd05293; LDH_1; 1.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 3.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR018177; L-lactate_DH_AS.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF16; L-LACTATE DEHYDROGENASE; 1.
DR   Pfam; PF02866; Ldh_1_C; 4.
DR   Pfam; PF00056; Ldh_1_N; 2.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   PROSITE; PS00064; L_LDH; 2.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU000496};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU000496};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT   DOMAIN          26..168
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          171..204
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   DOMAIN          236..351
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   DOMAIN          333..493
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          496..533
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   DOMAIN          537..640
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
SQ   SEQUENCE   663 AA;  72570 MW;  4C5946882850EF21 CRC64;
     MAEKMLKTVG AVLHEIAPPA EKSPQKITVV GTGQVGMACA YSILQQSDFK RTCSELVLVD
     VVANKVKGEV MDLQHGLAFT GRCVVKGDTT YECTAGSKLC IVTAGLRQKE GESRLSLVQR
     NTDIFKKIIP ELVKYSPETI IMVVSNPVDV LTYVTWKLSG LPRERVFGSG TNLDSARFRF
     LLSQRLNIAP SSCHGWIIGE HGDSSGTFVI AEGHDQKGNV LKVSKIISST EATECVPVWS
     GVNVAGVTLA EVSKTLSSKL SLESWEMDLH RQVVESAYEI IKMKGYTCWG IGLSVAKIAR
     GIIHNSRNVC ALTTNVKGMH GITDDVYLSL PCVVGMNGIT HIIKQNLSKE EGLCSELSLV
     DVVSNKVKGE MMDLQHGLAF TRRCVVNADT DYACTAGSNL CIVTAGLRQK EGESRLSLVQ
     RNTNILKKII PELVKYSPET LIMVVSNPGQ KHLPLNTKVM LRYKPIKFDP YSVDVLTYVT
     WKLSGLSRER VFGSGTNLDS ARFRFLLSQE LNVSPSSCHA WIIGEHGDSS VTACISSAYE
     IIKLKGYTCW GIGLSVAKIT RGIMRNSRNL NALSINVKVG IDFSQCVSAT RYVQGLHGIT
     DDVYLSVPCV VGVNGVTHVV KQTLNKEEIE KLHQSWKTLF TVQTQIEFDT TEKNTKKGGC
     LLS
//
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