ID W2STE0_NECAM Unreviewed; 663 AA.
AC W2STE0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=L-lactate dehydrogenase {ECO:0000256|ARBA:ARBA00012967, ECO:0000256|RuleBase:RU000496};
DE EC=1.1.1.27 {ECO:0000256|ARBA:ARBA00012967, ECO:0000256|RuleBase:RU000496};
GN ORFNames=NECAME_14040 {ECO:0000313|EMBL:ETN71967.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN71967.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC Evidence={ECO:0000256|RuleBase:RU000496};
CC -!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate
CC from pyruvate: step 1/1. {ECO:0000256|ARBA:ARBA00004843,
CC ECO:0000256|RuleBase:RU000496}.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CC {ECO:0000256|ARBA:ARBA00006054}.
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DR EMBL; KI666148; ETN71967.1; -; Genomic_DNA.
DR RefSeq; XP_013294194.1; XM_013438740.1.
DR AlphaFoldDB; W2STE0; -.
DR STRING; 51031.W2STE0; -.
DR EnsemblMetazoa; NECAME_14040; NECAME_14040; NECAME_14040.
DR GeneID; 25354067; -.
DR KEGG; nai:NECAME_14040; -.
DR CTD; 25354067; -.
DR OMA; YTCWGIG; -.
DR OrthoDB; 5344346at2759; -.
DR UniPathway; UPA00554; UER00611.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR CDD; cd05293; LDH_1; 1.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR018177; L-lactate_DH_AS.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF16; L-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02866; Ldh_1_C; 4.
DR Pfam; PF00056; Ldh_1_N; 2.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS00064; L_LDH; 2.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU000496};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000496};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 26..168
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 171..204
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT DOMAIN 236..351
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT DOMAIN 333..493
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 496..533
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT DOMAIN 537..640
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
SQ SEQUENCE 663 AA; 72570 MW; 4C5946882850EF21 CRC64;
MAEKMLKTVG AVLHEIAPPA EKSPQKITVV GTGQVGMACA YSILQQSDFK RTCSELVLVD
VVANKVKGEV MDLQHGLAFT GRCVVKGDTT YECTAGSKLC IVTAGLRQKE GESRLSLVQR
NTDIFKKIIP ELVKYSPETI IMVVSNPVDV LTYVTWKLSG LPRERVFGSG TNLDSARFRF
LLSQRLNIAP SSCHGWIIGE HGDSSGTFVI AEGHDQKGNV LKVSKIISST EATECVPVWS
GVNVAGVTLA EVSKTLSSKL SLESWEMDLH RQVVESAYEI IKMKGYTCWG IGLSVAKIAR
GIIHNSRNVC ALTTNVKGMH GITDDVYLSL PCVVGMNGIT HIIKQNLSKE EGLCSELSLV
DVVSNKVKGE MMDLQHGLAF TRRCVVNADT DYACTAGSNL CIVTAGLRQK EGESRLSLVQ
RNTNILKKII PELVKYSPET LIMVVSNPGQ KHLPLNTKVM LRYKPIKFDP YSVDVLTYVT
WKLSGLSRER VFGSGTNLDS ARFRFLLSQE LNVSPSSCHA WIIGEHGDSS VTACISSAYE
IIKLKGYTCW GIGLSVAKIT RGIMRNSRNL NALSINVKVG IDFSQCVSAT RYVQGLHGIT
DDVYLSVPCV VGVNGVTHVV KQTLNKEEIE KLHQSWKTLF TVQTQIEFDT TEKNTKKGGC
LLS
//