ID W2SUJ2_NECAM Unreviewed; 269 AA.
AC W2SUJ2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=ATP citrate synthase {ECO:0000256|ARBA:ARBA00012639};
DE EC=2.3.3.8 {ECO:0000256|ARBA:ARBA00012639};
DE Flags: Fragment;
GN ORFNames=NECAME_18354 {ECO:0000313|EMBL:ETN73414.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN73414.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660918; ETN73414.1; -; Genomic_DNA.
DR RefSeq; XP_013295641.1; XM_013440187.1.
DR AlphaFoldDB; W2SUJ2; -.
DR STRING; 51031.W2SUJ2; -.
DR EnsemblMetazoa; NECAME_18354; NECAME_18354; NECAME_18354.
DR GeneID; 25358378; -.
DR KEGG; nai:NECAME_18354; -.
DR CTD; 25358378; -.
DR OMA; EACIMCI; -.
DR OrthoDB; 3626847at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003878; F:ATP citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd06100; CCL_ACL-C; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR Gene3D; 3.40.50.261; Succinyl-CoA synthetase domains; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR005811; SUCC_ACL_C.
DR InterPro; IPR016102; Succinyl-CoA_synth-like.
DR PANTHER; PTHR23118; ATP-CITRATE SYNTHASE; 1.
DR PANTHER; PTHR23118:SF42; ATP-CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR Pfam; PF00549; Ligase_CoA; 1.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:ETN73414.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..74
FT /note="ATP-citrate synthase/succinyl-CoA ligase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00549"
FT NON_TER 269
FT /evidence="ECO:0000313|EMBL:ETN73414.1"
SQ SEQUENCE 269 AA; 28543 MW; A0E99FCDC1B3ACF4 CRC64;
MIVLLGEVGG VEEYKIVDAL KNGTITKPLV AWCIGTCVDQ ISSEVQFGHA GASANAQGET
AVAKNAALKA AGALVPKSFD DLGKLIKTTF DGLVAKGIVT LQKELPPPAV PMDYAWAREL
GLIRKPASFM TSICDERGEE LNYAGVPITK VLQQDIGIGG VLGLLWFQKR LPAYANKFIE
ICLMLTADHG PAVSGAHNTI VCARAGKDLI SSLVSGLLTI GDRFGGALDG AARQFSEAVD
KGWSPMQFVN EMRKQGKHIM GIGHRVKSV
//
