ID   W2SY64_NECAM            Unreviewed;       588 AA.
AC   W2SY64;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=SPRY domain protein {ECO:0000313|EMBL:ETN73801.1};
GN   ORFNames=NECAME_13405 {ECO:0000313|EMBL:ETN73801.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN73801.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
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DR   EMBL; KI660413; ETN73801.1; -; Genomic_DNA.
DR   RefSeq; XP_013296028.1; XM_013440574.1.
DR   AlphaFoldDB; W2SY64; -.
DR   STRING; 51031.W2SY64; -.
DR   EnsemblMetazoa; NECAME_13405; NECAME_13405; NECAME_13405.
DR   GeneID; 25353433; -.
DR   KEGG; nai:NECAME_13405; -.
DR   CTD; 25353433; -.
DR   OMA; KYSHDSV; -.
DR   OrthoDB; 170308at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd16566; RING-HC_RSPRY1; 1.
DR   CDD; cd12883; SPRY_RING; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR045129; RNF123/RSPRY1-like.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035774; SPRY_RSPRY1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13363:SF6; RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          271..457
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   DOMAIN          502..537
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   588 AA;  65932 MW;  F4C473DD6B8E5F1C CRC64;
     MGSCLCKEKA RRNHDSNSSR GSRACRRTEE RNRSPQSFEQ EVDFETEGSS QLGRRMSMTN
     YVGNDVKDLI RQTLKVIRSL VNNEQDPPAS LLKLNMIAER EKGWLLVVES LIETVPDDDS
     LGPAVITLFL DECPLPSKDT VHRLLCSLRL DQASSSSSTR KRSWHRNTCI VLGSLAEKLA
     GSSSVAMCNP TTLNYLISRI VPPFTQARVV LFALLALEKF AQTSENQFLI SRTLEQAASH
     PLKQLEEWRH CTNNAMKRQV GFCATWALDN IFITPNRTYA YETTDVSKIN AMLNHEDVSE
     YLKIGPDGLE ARCDVSSFES VRCTFAVQDG VWFYEATVFT PGVMQIGFAT KRSRFLNHEG
     YGIGDDESSV AYDGCRQLLW HNAHSSRHEH EPWCPGDVVG CLLNIPMGTV MFFLNGRPLQ
     RPHLEFLRNR PAGDGVFAAA SFMSFQQCRF NFGAEPFKYP PEVAFSTFND GGATLTLEQK
     TILPRRRRLE LLQKEPIPED YCTICYANPG DTVLSPCMHG GICNTCSLQM DQCPMCRQPI
     ENRLAIDEAP PAVVRKVSAA QLYSSSSQHR LSAGQATFLP TQRVTTEL
//