ID W2SYL0_NECAM Unreviewed; 322 AA.
AC W2SYL0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Nematode cuticle collagen domain protein {ECO:0000313|EMBL:ETN74643.1};
GN ORFNames=NECAME_03956 {ECO:0000313|EMBL:ETN74643.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN74643.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660344; ETN74643.1; -; Genomic_DNA.
DR RefSeq; XP_013296870.1; XM_013441416.1.
DR AlphaFoldDB; W2SYL0; -.
DR EnsemblMetazoa; NECAME_03956; NECAME_03956; NECAME_03956.
DR GeneID; 25343989; -.
DR KEGG; nai:NECAME_03956; -.
DR CTD; 25343989; -.
DR OMA; FMTIANE; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR PANTHER; PTHR24637:SF428; SCAVENGER RECEPTOR CLASS A MEMBER 3; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 3.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 4: Predicted;
KW Collagen {ECO:0000313|EMBL:ETN74643.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..57
FT /note="Nematode cuticle collagen N-terminal"
FT /evidence="ECO:0000259|SMART:SM01088"
FT REGION 80..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..110
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..195
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 32367 MW; 5C6239AAFDD9667A CRC64;
MSSTAVETGL TCFIGVATMS SVITVIYLVN EINNYHNNAI EELSDFMDLA NSAWQELSPS
GQQLQEKKNT LELSRHRRQL SSHCKCEPPP EGCPPGPPGP PGPPGRTGEP GLPGIPGRPG
HDGVTVNATL GLGGCIKCPP GPPGPPGPDG PVGAPGMDGK PGENVGGRTQ GLPGPPGPPG
EIGPPGLPGN PGPPGEPGAS GIRSIGLPGP TGPPGPIGPP GPVGANATFS GIGVPGPPGP
MGKPGNPGLP GPNGIPGKMG SPGFPGIDGQ YCPCPPRTKR MERSDIHDPG PGIGFSRQRG
RILSTGVRRR GVRIPNITAR QH
//
