ID W2SZ04_NECAM Unreviewed; 104 AA.
AC W2SZ04;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Kunitz/Bovine pancreatic trypsin inhibitor domain protein {ECO:0000313|EMBL:ETN74191.1};
GN ORFNames=NECAME_13135 {ECO:0000313|EMBL:ETN74191.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN74191.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660379; ETN74191.1; -; Genomic_DNA.
DR RefSeq; XP_013296418.1; XM_013440964.1.
DR AlphaFoldDB; W2SZ04; -.
DR EnsemblMetazoa; NECAME_13135; NECAME_13135; NECAME_13135.
DR GeneID; 25353163; -.
DR KEGG; nai:NECAME_13135; -.
DR CTD; 25353163; -.
DR OMA; VATQECY; -.
DR OrthoDB; 3558236at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR PANTHER; PTHR47248:SF6; BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47248; PROTEIN CBG06772; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..104
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004824708"
FT DOMAIN 36..97
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 104 AA; 11516 MW; EA58BB47A2176822 CRC64;
MYSVKLLLLS LAALVCGGRF PDPPVFAAPQ HYPSICYLPP DSGLCPQNGA SAEELSPDLL
TRYYFDVTTE QCYPFGVQNC GGNENRFKSR ADCQNFCRLD NKSL
//
