ID W2SZ43_NECAM Unreviewed; 574 AA.
AC W2SZ43;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN ORFNames=NECAME_03895 {ECO:0000313|EMBL:ETN74980.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN74980.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR EMBL; KI660323; ETN74980.1; -; Genomic_DNA.
DR RefSeq; XP_013297207.1; XM_013441753.1.
DR AlphaFoldDB; W2SZ43; -.
DR STRING; 51031.W2SZ43; -.
DR EnsemblMetazoa; NECAME_03895; NECAME_03895; NECAME_03895.
DR GeneID; 25343929; -.
DR KEGG; nai:NECAME_03895; -.
DR CTD; 25343929; -.
DR OMA; DMIMVIP; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF51; GLUTAMINASE 3-RELATED; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 27..115
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
SQ SEQUENCE 574 AA; 65523 MW; D1CF498CB6EA2E20 CRC64;
MRENTIVGGL LLGRSLSHDI NYHAHLQALI FDLYRDEKAN KIYIPKFFKE LVDAGIRKDD
PRLREMIKQV REAEHEDEVA HDKEHLFMNK EAFCKCVGGS IGVIGKALKK QLVIPDWPSF
TSVMTEIFEE CCKYSSGQNF VRFPHNVVMF PVATYIPQLA RADPNTFAAS VCTVDGQRKS
WGEALMPFCL QSVSKPFTYA LVHEELGPDE LHNHVGQEPS GRLFNDISLD HNKKPHNPLI
NAGAIVVASL MKRRASLSDR FDFVRFRKQF RLCALTNVPR FQAIHQMRRF CGVGYVGFNN
AVFLSERETA DRNYALSYYM REHKVFPPDT HLQDTLDLYF QLCSIETNCD TLAVMAATLA
NGGVNPMNGE RVINNRCLPF RSTFLFVGLP AKSGVSGDMI MVIPNVMGIA IYSPRLDSLG
NTYRGLKFAE AFIEKFNFHN YDSLVYSDCQ KMDPRKTVVE NDLDNASRFM YAAKQGDISA
MKRYQHNAKE VAIARKILAT APATGYEPAR AFFLESSNRS ENFSFIYSEP EDKFQRTPLD
DAKFFNHREC MDVIEKAIER WKAAEEQPRT DWQP
//
