ID W2T6H9_NECAM Unreviewed; 560 AA.
AC W2T6H9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Nematode cuticle collagen domain protein {ECO:0000313|EMBL:ETN77493.1};
GN ORFNames=NECAME_03157 {ECO:0000313|EMBL:ETN77493.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN77493.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI660167; ETN77493.1; -; Genomic_DNA.
DR RefSeq; XP_013299720.1; XM_013444266.1.
DR AlphaFoldDB; W2T6H9; -.
DR STRING; 51031.W2T6H9; -.
DR EnsemblMetazoa; NECAME_03157; NECAME_03157; NECAME_03157.
DR GeneID; 25343195; -.
DR KEGG; nai:NECAME_03157; -.
DR CTD; 25343195; -.
DR OMA; GAHQHED; -.
DR OrthoDB; 2883557at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR InterPro; IPR002486; Col_cuticle_N.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR PANTHER; PTHR24637:SF422; GENE, 37797-RELATED; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 4: Predicted;
KW Collagen {ECO:0000313|EMBL:ETN77493.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..57
FT /note="Nematode cuticle collagen N-terminal"
FT /evidence="ECO:0000259|SMART:SM01088"
FT REGION 80..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..355
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..491
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..536
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 51981 MW; 628F509484EE38E6 CRC64;
MGTTTLVGGV ATMSAVAVVI SLVSVTYIVN DINTFYEDAL LELDNFKDIA NSAWHKMRTA
SEVAREKRAV LIRRRNAGGS ACNCGHQASS CPAGPPGPPG EAGQPGDDGE AGALGQPGRD
GSSEGGNGSN GSCIQCPAGP PGPPGPDGDA GPAGPDGNPG APGAASGPGP AGPQGPPGDA
GQPGAPGEAG APGEVGAPGT SGKGLPGPAG PAGSIGAPGQ PGADGDAAGA GNPGPPGPSG
PAGSPGQSGT DGAPGNPGAD GTPGSDGEYC PCPARSSAPM DAPSSANYEN AALADNPEPA
EIGKDDNDSN SGSDSISGSD SSSDEGEDEK SRKALHRVAA TRRLAAKKVV KKVARNAAKK
PALPAGGASI GAPARGGHGQ YSASLPGAAS GPGSPGVPSA PACPGLPAGP AGPGGPGLAP
PPAPPSCPGC PAGPAGPAGP AGPGRPFPLV PGAPGCPGGP GGPAGPGPDP PPGAPGFPSG
PAGPASPSGP GGPGGPTGHV MQLPFEPSPP PELPSRPGCP GAPGSPSSPG SPASPGGPGG
PAGQLLACWP QLHPDPPPVA
//
