ID W2TFH5_NECAM Unreviewed; 547 AA.
AC W2TFH5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=KH domain protein {ECO:0000313|EMBL:ETN80339.1};
DE Flags: Fragment;
GN ORFNames=NECAME_09277 {ECO:0000313|EMBL:ETN80339.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN80339.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI659137; ETN80339.1; -; Genomic_DNA.
DR RefSeq; XP_013302566.1; XM_013447112.1.
DR AlphaFoldDB; W2TFH5; -.
DR STRING; 51031.W2TFH5; -.
DR EnsemblMetazoa; NECAME_09277; NECAME_09277; NECAME_09277.
DR GeneID; 25349306; -.
DR KEGG; nai:NECAME_09277; -.
DR CTD; 25349306; -.
DR OMA; CETIRIV; -.
DR OrthoDB; 2995592at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IEA:InterPro.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF7; SYNAPTIC FUNCTIONAL REGULATOR FMR1; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF17904; KH_9; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 212..287
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 291..363
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 386..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..476
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETN80339.1"
SQ SEQUENCE 547 AA; 60831 MW; C7C891677C10B5E0 CRC64;
VYIDGVYYPA IAERISEDEK TLETSFPGDW RARESVSFGN CRVLQATTSH PIHKGDIIEA
LFQQQNGQTG WQKASVREIK ADFIVVDSVE GPQHTDVVAA NKCRSSGAQY LKITPADLRT
DTISVPEDLV DYFSSEKNLL EFQNTVKDIA MSFDKEKREI KLSSFGTISL KKAIVLSEMY
FRDVRLKNQL RARAEEAERM LQHGGQRSDR DSPFVDEFEV AADLMGLAIG THGSNIQRAR
NVEDVDDIQV FEGGGDGQPC IIKVSIRKYS ICSQIFAKTA AAAQKARAQL DFGVECVHVP
RFLVGKLIGK NGKCIQEIVD KSGVVRVQIA GEDDDTMDPV PFTFTGTRES TSMASFLVDF
QINHLKETEG LRNNIEDMMR QAYSNNERYQ RNDSFQRNGY GDRGGFDRRG RRGRGRGGYR
NGNSQNGGSA NGSSSNVGKP WRGGDGARYS DEEWSGTEES KHREEHVEDQ ERRQGRQRGG
GSGSGERGGS AGRRRGMHLL LVMTHTILRS EQFILVVQIH CARVEPTCNS NNPINVVGRA
GFNRNGA
//
