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Database: UniProt
Entry: W2TH59_NECAM
LinkDB: W2TH59_NECAM
Original site: W2TH59_NECAM 
ID   W2TH59_NECAM            Unreviewed;       407 AA.
AC   W2TH59;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Ligand-gated ion channel {ECO:0000313|EMBL:ETN81168.1};
GN   ORFNames=NECAME_02211 {ECO:0000313|EMBL:ETN81168.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81168.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|ARBA:ARBA00008685}.
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DR   EMBL; KI658833; ETN81168.1; -; Genomic_DNA.
DR   RefSeq; XP_013303395.1; XM_013447941.1.
DR   AlphaFoldDB; W2TH59; -.
DR   EnsemblMetazoa; NECAME_02211; NECAME_02211; NECAME_02211.
DR   GeneID; 25342251; -.
DR   KEGG; nai:NECAME_02211; -.
DR   CTD; 25342251; -.
DR   OMA; GGAIMEY; -.
DR   OrthoDB; 2967760at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR   PANTHER; PTHR42643:SF13; IONOTROPIC RECEPTOR 31A, ISOFORM C; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        97..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..365
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00060"
SQ   SEQUENCE   407 AA;  46530 MW;  4E797F4FAF8ACE70 CRC64;
     MEILKDLAEL LDLKYEILPW STTEAVEMNW DDVFDALRRK KDADIVAGTS IMTYNRSLIA
     DFTYPIQFVH TGILTAAPKR SRNDAMLIIT ESLQWEVWMA TAICIFVSAL VLFFLSNTLR
     RVYDEEAFSL FGSVWVFFSI FVQQGIPEQP RSWSIRILIS MWWLASITLM ATFTGSLVAI
     FAVEKAYLPF NSFEELVNLV KQGKYMILMS KQSMAKSDII KISPLPIHKE LWYEVNVNNK
     IKYANNTKDA VDFMLNDPSY VILGSTTILR MYAQTDCRLA LLQETILPTL ISIALTKDSP
     YTTFFSNRIQ NLVELGFTAK WIRDYSSYMA SKNTVFCNET FSPAMKGTLD LKRAQGAFWI
     LIGGLLVAII TLFIEITVHS MNNGAASEDG RIARYKQWLC SCIRHIR
//
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