ID W2TH59_NECAM Unreviewed; 407 AA.
AC W2TH59;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Ligand-gated ion channel {ECO:0000313|EMBL:ETN81168.1};
GN ORFNames=NECAME_02211 {ECO:0000313|EMBL:ETN81168.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81168.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; KI658833; ETN81168.1; -; Genomic_DNA.
DR RefSeq; XP_013303395.1; XM_013447941.1.
DR AlphaFoldDB; W2TH59; -.
DR EnsemblMetazoa; NECAME_02211; NECAME_02211; NECAME_02211.
DR GeneID; 25342251; -.
DR KEGG; nai:NECAME_02211; -.
DR CTD; 25342251; -.
DR OMA; GGAIMEY; -.
DR OrthoDB; 2967760at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF13; IONOTROPIC RECEPTOR 31A, ISOFORM C; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 97..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..365
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 407 AA; 46530 MW; 4E797F4FAF8ACE70 CRC64;
MEILKDLAEL LDLKYEILPW STTEAVEMNW DDVFDALRRK KDADIVAGTS IMTYNRSLIA
DFTYPIQFVH TGILTAAPKR SRNDAMLIIT ESLQWEVWMA TAICIFVSAL VLFFLSNTLR
RVYDEEAFSL FGSVWVFFSI FVQQGIPEQP RSWSIRILIS MWWLASITLM ATFTGSLVAI
FAVEKAYLPF NSFEELVNLV KQGKYMILMS KQSMAKSDII KISPLPIHKE LWYEVNVNNK
IKYANNTKDA VDFMLNDPSY VILGSTTILR MYAQTDCRLA LLQETILPTL ISIALTKDSP
YTTFFSNRIQ NLVELGFTAK WIRDYSSYMA SKNTVFCNET FSPAMKGTLD LKRAQGAFWI
LIGGLLVAII TLFIEITVHS MNNGAASEDG RIARYKQWLC SCIRHIR
//