ID   W2THY6_NECAM            Unreviewed;       894 AA.
AC   W2THY6;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE            EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN   ORFNames=NECAME_08684 {ECO:0000313|EMBL:ETN81204.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81204.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- SIMILARITY: Belongs to the RNase H family.
CC       {ECO:0000256|ARBA:ARBA00005300}.
CC   -!- SIMILARITY: Belongs to the SNF7 family.
CC       {ECO:0000256|ARBA:ARBA00006190}.
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DR   EMBL; KI658822; ETN81204.1; -; Genomic_DNA.
DR   RefSeq; XP_013303431.1; XM_013447977.1.
DR   AlphaFoldDB; W2THY6; -.
DR   STRING; 51031.W2THY6; -.
DR   EnsemblMetazoa; NECAME_08684; NECAME_08684; NECAME_08684.
DR   GeneID; 25348713; -.
DR   KEGG; nai:NECAME_08684; -.
DR   CTD; 25348713; -.
DR   OrthoDB; 3280806at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR   GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR   CDD; cd09280; RNase_HI_eukaryote_like; 1.
DR   Gene3D; 6.10.140.1230; -; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 4.
DR   InterPro; IPR009027; Ribosomal_bL9/RNase_H1_N.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR005024; Snf7_fam.
DR   PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR   PANTHER; PTHR10642:SF26; RIBONUCLEASE H1; 1.
DR   Pfam; PF01693; Cauli_VI; 4.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF03357; Snf7; 1.
DR   SUPFAM; SSF55658; L9 N-domain-like; 4.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT   DOMAIN          534..680
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
FT   REGION          292..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   894 AA;  101355 MW;  B5D09CC5F63CECC8 CRC64;
     MMGLFGKKKD PKEQVREMQR KMRGEIRALD RQIYGIQREE QKVTKEIKEA AKKGDRDVCV
     VLAKSLLQSR KAVAKIHVSK AQINSVIMCM QEQLATMRMA GSLQKSTQVL QAMQSLVKVP
     EIMKTMREMS QEMMKLGIIE EMIEETMDSM EPADLEEAAQ IIPITKKNYI GLRMSKFYAV
     AHGFERGIYE NWDDAKKQID DFPQAVYKKF STREEAEEYF NARQPKKVEL AFPEPNLEKY
     YAVARGYSVG VFTNYEDVKK YIEDYPQPLY KKFDNLDDAV AYFNKFFHGN EKKDPEQEKQ
     EKAPQNEESS NKKIPKEDKT VTYYAVARGH TTGVFLSWEE CKKQTAGFKG AKFKKFDNEE
     EAKMFAEGKT LKQIEEAVAG RKRPAETSSS SDNAAPEKKL KNSSSFVKLD KVEIPIKLYE
     KLLNSMAKSG FYAVAKGRKV GIYTTWDQCR VQVDGYPQAR FKKFGTENEA REFIASFQLA
     RTAAVSSKSS RGNSLVQAST QLFMSNIISR KRKSTESTDL AVPKRLKDCD EAIWEDAPVV
     YTDGACSGNG QNSAKAGYGV YWGADHVDNK WGPVHGVATN NRGELLAVDV ALKQAISKKM
     ECLIVRTDSQ LLMKSMDCYI ENWKRNSWKT STGEAVKNQD LLRSIDESIR KIHVKFEYVP
     GHSGVDGNEA ADELARRGAE IEEALSWLVE TASRKNISPE EFRVLHFERP WATAPVVITH
     GWKAELGMSA NGLIRWLHNP ERDVNIEFDS QDSLYTVQVK AVFYAILSSF LETVTHCVQI
     HEHAVRTNAA EDLMMQARKF EYDVIGLTET RRRRPLYAVY DTGEGLFLGT CDSGGIGGVG
     VLVNTNMAAK LHVLDGDALK KLHVTLEEAT SRKNVSLCSE NLFRERHSNE LVRM
//