ID W2TJQ8_NECAM Unreviewed; 516 AA.
AC W2TJQ8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=HEAT repeat protein {ECO:0000313|EMBL:ETN81849.1};
GN ORFNames=NECAME_00199 {ECO:0000313|EMBL:ETN81849.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81849.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit A family.
CC {ECO:0000256|ARBA:ARBA00038332}.
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DR EMBL; KI658623; ETN81849.1; -; Genomic_DNA.
DR RefSeq; XP_013304076.1; XM_013448622.1.
DR AlphaFoldDB; W2TJQ8; -.
DR STRING; 51031.W2TJQ8; -.
DR EnsemblMetazoa; NECAME_00199; NECAME_00199; NECAME_00199.
DR GeneID; 25340243; -.
DR KEGG; nai:NECAME_00199; -.
DR CTD; 25340243; -.
DR OMA; CRETVIM; -.
DR OrthoDB; 759105at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR PANTHER; PTHR10648:SF4; PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED; 1.
DR PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR Pfam; PF02985; HEAT; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 9.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 18..56
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 103..141
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 142..189
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 220..258
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 259..296
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 302..340
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 341..379
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 380..418
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 458..496
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 516 AA; 57657 MW; 54C199324D9DCE63 CRC64;
MATAVSQSPS ESDDSLYPIA VLIDELRNED VHLRLNSIRK LSTIALALGV ERTRNELIQF
LTVEQPLFFA DTIYDEDEVL LILAEQLGNF TPLVGGPEYV HCLLPPLENL ATVEETVVRD
KAVESLRKLA DKLSTPALEE YFIPMLKRLA TGGLFRQLCR DDTPMVRRAA AAKLGDFAKV
FERDYLVEEL HAMFCDLAVD EQGCIAMAGL LSEESRRDLV RPVLSGLIDD KSWRVRFMVA
EKLTEIQEAV GEDMTMTELV PAFTNLLKDP EGEVRGAAAQ KLNTFCANLK RSARETAILN
NILPVVKDLV IDPNQHVKTE LAGVIMGLAP LVGKENTISQ LLPIYMQLLK DSTAEVRLNI
ISSLDKVNDV IGASQLSQSL LPAIVELAED GKWRVRLAIV QFMPLLAAQL GQEFFDEKML
PLCLNWLCDH VYAIREATTS ILTELAKKFG CDWASKNIMP KLLTMSKDLN YLHRMTCLFC
LNSLAEAVGP QQTAKEIMPI IKEVFVSSLH FCFVFF
//
