ID W2TKR4_NECAM Unreviewed; 490 AA.
AC W2TKR4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Tetratricopeptide repeat protein {ECO:0000313|EMBL:ETN81612.1};
GN ORFNames=NECAME_08410 {ECO:0000313|EMBL:ETN81612.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN81612.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI658687; ETN81612.1; -; Genomic_DNA.
DR RefSeq; XP_013303839.1; XM_013448385.1.
DR AlphaFoldDB; W2TKR4; -.
DR STRING; 51031.W2TKR4; -.
DR EnsemblMetazoa; NECAME_08410; NECAME_08410; NECAME_08410.
DR GeneID; 25348440; -.
DR KEGG; nai:NECAME_08410; -.
DR CTD; 25348440; -.
DR OMA; PFAHFQH; -.
DR OrthoDB; 178259at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44140; LD25575P; 1.
DR PANTHER; PTHR44140:SF2; LD25575P; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13414; TPR_11; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50005; TPR; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..490
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004825561"
FT REPEAT 29..62
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 97..130
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 211..244
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 330..363
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 384..452
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
SQ SEQUENCE 490 AA; 56216 MW; 7C5C410FC8F15CF0 CRC64;
MRPLITGIST SFLTFSVYLT VVHGNKAEVN KHLELGKSFL AKGQFADALT HYHAAIEMDP
TNYLTFYRRA TVYLAMGKSK QAIPDLDKVV ELKGDFTAAR IQRGNVLLKQ GEIDAAESDF
HAVLATEPSH SEVSAKLDLI ADLRQYVHQA KSFYERDDQH SAEYYLNKAL EHLVWDPSLY
RMRAKCLESR GEIRKAIADM RTLTKLVADS TEDFLKISHL YYGIGDVEEA LSQIRECLKL
NPDHKECFPF YKKVKKLAKM RESLNDAKQR EDWMGCLEKG QQILKYENKV LGIQMDTFRQ
LCKCNMEAGH ITEAIQQCTE VLTNSDPNDV DVLCDRAEAY IMDERYDEAI EDYQKAQQVN
EDSRRVREGL DKAQKLKKQA GKRDYYKILG LKRNASKRDI TKAYRKMAQK WHPDNFNDAA
EKKKAEQKFI DIAAAKEVLS DDEKRAQYDQ GIDPLDPEAQ QQGHTHFHSG FPGGFMFREG
GGPFSFKFNF
//
