ID W2TN74_NECAM Unreviewed; 1924 AA.
AC W2TN74;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Myosin head {ECO:0000313|EMBL:ETN83119.1};
GN ORFNames=NECAME_07589 {ECO:0000313|EMBL:ETN83119.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83119.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KI658303; ETN83119.1; -; Genomic_DNA.
DR RefSeq; XP_013305346.1; XM_013449892.1.
DR STRING; 51031.W2TN74; -.
DR EnsemblMetazoa; NECAME_07589; NECAME_07589; NECAME_07589.
DR GeneID; 25347619; -.
DR KEGG; nai:NECAME_07589; -.
DR CTD; 25347619; -.
DR OMA; TWDWFLL; -.
DR OrthoDB; 2878043at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 3.
DR Gene3D; 1.20.5.370; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF51; MYOSIN-1; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF50084; Myosin S1 fragment, N-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 14..62
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 66..770
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 645..667
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 909..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1107..1920
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 159..166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1924 AA; 221973 MW; D3D42B5FDD68DE81 CRC64;
MVMYHLQEHS RPYDSKKNVW VPDPEEGYVA ADIKSAKGDN VIVVIGDKEK TFKKDLLQEM
NPPKFEKTED MSNLTFLNDA SVLHNLRSRY AAMLIYTYSG LFCVVINPYK RLPIYTESVA
TMFMGKRRTE MPPHLFAVSD EAYRNMLMDH ENQSMLITGE SGAGKTENTK KVIAYFATVG
ASQQGAAAVT DGKKKVTLED QIVQTNPVLE AFGNAKTVRN NNSSRFGKFI RIHFSKLGKV
ASCDIEHYLL EKSRVIRQAP GERCYHIFYQ IFSDYKPELK QKLLLDKPLN EYYFVAQAEL
TIDGVNDTEE FQLTDEAFDI LNFSEQEKMD CYRLMAGHMH MGAMKFKQRP REEQAEPDGQ
EDAEKACAMY GVDVDQFLKA LVSPRVKVGT EWVSKGQNVE QVNWAVGAMA KGLYARVFHW
LVKKCNLTLD QQGTPRDYFI GVLDIAGFEI FDFNSFEQLW INFVNEKLQQ FFNHHMFVLE
QEEYAREGIQ WTFIDFGLDL QACIELIEKP LGIISMLDEE CIVPKATDMT LAQKLNEQHL
GKHPNFEKPK PPKGKQAEAH FAMRHYAGTV RYNVTNWLEK NKDPLNDTVV SVMKASKGNE
LLNEVWRDYV TQEEAANAAK SGGGGAKRGK SGSFMTVSMM YRESLNNLMN MLHKTHPHFI
RCIIPNEKKK SGLIDASLVL NQLTCNGVLE GIRICRKGFP NRTLHPDFVQ RYALLAAKEA
KGTDDPKTNA EAIMQALVNK KQLNEEQFRI GHTKVFFKAG VVAHIEDLRD AKLNALISGF
QACIRQYNAI IERADRQKQL NAYIVLQRNI RSWCILRTWD WFLLFGKLRP QLKSGKMAEE
LAKMTEEQKN LEAASAKAEN ERKAKEEMLN KLNADKNKLL EQLEMTKGGS ASIEEKLNKL
NNAKQELEKS LNDVNDKLSE QEERNAELER QKRKAQQEIE NMKKNMEGVD GNLLKSIEEK
EAKENQIRSL QDEINAQDET IAKLNKEKKH QEEVNRQLVD DLQAEEAKQA QAARLKQKLE
QTLDELEESI ERERRIRAET EKAKRKTEGE LKAAQENIDE ITKLKQEADI NLKKKEADLH
ALGVRIEDEQ AMGNRLTRQS KENAVRIIEI EDELEHERQS RAKADRARSE LQRELDELNE
RLDEQNNQMQ AQQELNKKKD AEILKCRRDL EDLNMSHEDQ LAALRKKNND QVAQLTSQLD
GLQKGKAKID KDKATLQKEL DDINAQVDQE SKARVEQERL AKQYEVQVAE LQQKVDEQTR
QISEFTSSKV RLVNDNSDLL HQMEELEVQL NNVNRAKAGF SSQLTEAKKA AEDETRERHD
LNATCKNLEH EIEQCREMLE EEINSKDDLQ RQLSRINSEI SQWKARYEGE GLVGADELED
LKRKQMARVM DLQEAISAAQ NKVNSLEKAK TKLMQETEEA RSDVDRHLTV IVSLEKKQKA
FDKIVDEWKQ KVEGIQKEID ATNRDSRNTS TEVFKVKSAM ENLSEQCETL RRENKNYAQE
IRDLNEQITQ GGRTFHDLQK AVKRMEIEKD ELQHALDEAE AALEAEESKV LRSQIEVQQI
RSDVEKRIQE KEDEFENTRR NHQRALESIQ ASLETEAKSK AELLRAKKKL ESDINQLEIA
LDHANKANVD AQKTLKRLFD QASRREVKEL QGQVDEEQRR REEIRENYLA TEKRLAIALA
ESEEILQRID AAEKNKKQLE LDQADLKSQN TELISSNSAL SAMKRKIESD VQVARNELDE
CLNELKASEE RARKAAADAD RLAEEVRQEQ EHAAHVDRHR KGLELAYKEL QSKIEDSEKA
MLQFGQKALA KVEERVRSLE NDYQAETRRH QEAIKGVTKQ ERRARELQFQ VEEDKKMFDR
LQEMVEKLQQ KIRVQKRQIE EAEEVATQNL SKFRQIQLAL ENAEERADVA ENSLVRMRSQ
KRVQ
//
