ID W2TPL0_NECAM Unreviewed; 399 AA.
AC W2TPL0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=FYVE zinc finger {ECO:0000313|EMBL:ETN82927.1};
GN ORFNames=NECAME_17601 {ECO:0000313|EMBL:ETN82927.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN82927.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI658335; ETN82927.1; -; Genomic_DNA.
DR RefSeq; XP_013305154.1; XM_013449700.1.
DR AlphaFoldDB; W2TPL0; -.
DR STRING; 51031.W2TPL0; -.
DR EnsemblMetazoa; NECAME_17601; NECAME_17601; NECAME_17601.
DR GeneID; 25357626; -.
DR KEGG; nai:NECAME_17601; -.
DR CTD; 25357626; -.
DR OMA; EIRCLRW; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15718; FYVE_WDFY1_like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR042234; WDFY1/WDFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46189; LD41958P; 1.
DR PANTHER; PTHR46189:SF1; LD41958P; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT REPEAT 191..224
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 234..275
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 277..348
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REPEAT 369..399
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 399 AA; 44416 MW; 134E2406FAADEC82 CRC64;
MRQYSAGHTS ALLHKIEGHV ARINDVVLLS KEEGVWTASD DRSVRLYLKR DNGQFWPSIH
KIMPVAPTCI HYSEETSRLL VGLLNGHVYE YHVADDYNSM SDPEARRWTI HAGPISGLGI
ALNAELVFSC SKDKSVVWHC SETGIKRGAF HCDSSCTAMA IDLPFVFVGD HGGNVVVVRL
TGETAQMVSK LSAHTGPVSS LAWNRTKEIL YSGSHDNLVI MWDIGGKRGE AYELNGHSSK
ITSLVVAPGA ARLFSADDAG KLVCWDMSAH RLETPGWKTA DNCEVCDAPF FWNLTAMWQR
KTVGQRQHHC RTCGKAVCGS CCSNWTVFPR MGYELPVRIC NMCHKKMEDN PQQFDLTPLS
VQHEIRSGVT AMHLQETSGR LVTATQNRVV MIWDIRSML
//