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Database: UniProt
Entry: W2TPL0_NECAM
LinkDB: W2TPL0_NECAM
Original site: W2TPL0_NECAM 
ID   W2TPL0_NECAM            Unreviewed;       399 AA.
AC   W2TPL0;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=FYVE zinc finger {ECO:0000313|EMBL:ETN82927.1};
GN   ORFNames=NECAME_17601 {ECO:0000313|EMBL:ETN82927.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN82927.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
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DR   EMBL; KI658335; ETN82927.1; -; Genomic_DNA.
DR   RefSeq; XP_013305154.1; XM_013449700.1.
DR   AlphaFoldDB; W2TPL0; -.
DR   STRING; 51031.W2TPL0; -.
DR   EnsemblMetazoa; NECAME_17601; NECAME_17601; NECAME_17601.
DR   GeneID; 25357626; -.
DR   KEGG; nai:NECAME_17601; -.
DR   CTD; 25357626; -.
DR   OMA; EIRCLRW; -.
DR   OrthoDB; 5385125at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15718; FYVE_WDFY1_like; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR042234; WDFY1/WDFY2.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46189; LD41958P; 1.
DR   PANTHER; PTHR46189:SF1; LD41958P; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   REPEAT          191..224
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          234..275
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          277..348
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
FT   REPEAT          369..399
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   399 AA;  44416 MW;  134E2406FAADEC82 CRC64;
     MRQYSAGHTS ALLHKIEGHV ARINDVVLLS KEEGVWTASD DRSVRLYLKR DNGQFWPSIH
     KIMPVAPTCI HYSEETSRLL VGLLNGHVYE YHVADDYNSM SDPEARRWTI HAGPISGLGI
     ALNAELVFSC SKDKSVVWHC SETGIKRGAF HCDSSCTAMA IDLPFVFVGD HGGNVVVVRL
     TGETAQMVSK LSAHTGPVSS LAWNRTKEIL YSGSHDNLVI MWDIGGKRGE AYELNGHSSK
     ITSLVVAPGA ARLFSADDAG KLVCWDMSAH RLETPGWKTA DNCEVCDAPF FWNLTAMWQR
     KTVGQRQHHC RTCGKAVCGS CCSNWTVFPR MGYELPVRIC NMCHKKMEDN PQQFDLTPLS
     VQHEIRSGVT AMHLQETSGR LVTATQNRVV MIWDIRSML
//
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