ID W2TQH7_NECAM Unreviewed; 559 AA.
AC W2TQH7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=SnoRNA binding domain protein {ECO:0000313|EMBL:ETN83929.1};
GN ORFNames=NECAME_01722 {ECO:0000313|EMBL:ETN83929.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83929.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family.
CC {ECO:0000256|ARBA:ARBA00009211}.
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DR EMBL; KI658066; ETN83929.1; -; Genomic_DNA.
DR RefSeq; XP_013306156.1; XM_013450702.1.
DR AlphaFoldDB; W2TQH7; -.
DR STRING; 51031.W2TQH7; -.
DR EnsemblMetazoa; NECAME_01722; NECAME_01722; NECAME_01722.
DR GeneID; 25341762; -.
DR KEGG; nai:NECAME_01722; -.
DR CTD; 25341762; -.
DR OMA; YIETFIR; -.
DR OrthoDB; 5489581at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR GO; GO:0030515; F:snoRNA binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP58/56_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58; 1.
DR PANTHER; PTHR10894:SF1; NUCLEOLAR PROTEIN 58; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..559
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004826736"
FT DOMAIN 321..440
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 467..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 62502 MW; 1317D2A679B2F8F9 CRC64;
MSCAWLFFAR ISILTSAHSY FRVKMLVLFE TAAGYAMFKL HNEKKLKNVD NIYDEFNTAE
KAQENLQLVA FKKFKSTADA VECASSLHDG KMNKTLKKLL KGKVDENEQL AVGDAKLGNL
IKASLCGSLE AKKWCSFKHE KLEVPCVHSP AVAELMRSIR SHIDSLLGEH KAELNAMNLA
VAHSLGRYKV KFNPEKIDTM IVQAVSLLDD LDKELNNYVM RCREWYGWHF PELGKIVQDH
QAFAKVVKAI GMRQNAATTD LSEILPEELE AKVKEEADIS MGTDISDLDL IHIRGLCDQI
IELSQYRAQL FDYLKNRMTA LAPNLTCLLG ELVGARLISH AGSLVSLAKA PASTVQILGA
EKALFRALKT KKDTPKYGLI YHAQLITQAP AKLKGKMARK LAAKCALATR IDALADESKG
AEIGLECRAA LEAVLRGEQE RGPKKISGGS HKHEKYHFKS ETFEYDNAND VPKKPLKRKY
EDDEENTASK KPKIEEEAFA FFFASAEGSE MTLLLLKLAH LLVIAMGNSK PWLLESFDVF
LMAYHKCRLG YESTRCLDA
//
