ID W2TRN4_NECAM Unreviewed; 336 AA.
AC W2TRN4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Nucleoside transporter {ECO:0000313|EMBL:ETN83692.1};
GN ORFNames=NECAME_17372 {ECO:0000313|EMBL:ETN83692.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83692.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; KI658129; ETN83692.1; -; Genomic_DNA.
DR RefSeq; XP_013305919.1; XM_013450465.1.
DR AlphaFoldDB; W2TRN4; -.
DR EnsemblMetazoa; NECAME_17372; NECAME_17372; NECAME_17372.
DR GeneID; 25357398; -.
DR KEGG; nai:NECAME_17372; -.
DR CTD; 25357398; -.
DR OMA; NEWWFTI; -.
DR OrthoDB; 239997at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF28; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 29..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 336 AA; 37760 MW; 4E4A2358DFE02B9E CRC64;
MSGSGSPSSS ASSPSDFPSL ISVVDRKHAV YGIFLLHGVG MLMSWNMFIT IAPQYYVDYW
FTVDGNATDY AESFMSVIGV TSQIPNVGVM FINMAITVAG SMMMRIAVPL VINCCLVMVI
ILLVIFVQPS DNDRNWFYIV TLIIIMLMNL CNGVYQNSIY GVVADFPDNY PNSLIIGNNL
CGIFTSVMSI FTTIVSPNDI MLNALLYFSI SLGVLVICGL SLIVLVKLPY YNYIMGIGER
ARQDDDAERP NLRQYLECFS YCWVQLFNNF FVYFVTLIIF PAMMSETPFY RQPGEPWGSV
FPENLYFAIN TFLNFNVFAS LGSLSANYVQ FVSIFW
//
