ID W2TS12_NECAM Unreviewed; 480 AA.
AC W2TS12;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=CDP-alcohol phosphatidyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=NECAME_01699 {ECO:0000313|EMBL:ETN83906.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83906.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC family. {ECO:0000256|ARBA:ARBA00010441}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI658066; ETN83906.1; -; Genomic_DNA.
DR RefSeq; XP_013306133.1; XM_013450679.1.
DR AlphaFoldDB; W2TS12; -.
DR STRING; 51031.W2TS12; -.
DR EnsemblMetazoa; NECAME_01699; NECAME_01699; NECAME_01699.
DR GeneID; 25341739; -.
DR KEGG; nai:NECAME_01699; -.
DR CTD; 25341739; -.
DR OMA; DAPNWIY; -.
DR OrthoDB; 5482983at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1760; -; 1.
DR InterPro; IPR043130; CDP-OH_PTrfase_TM_dom.
DR InterPro; IPR014472; CHOPT.
DR PANTHER; PTHR10414; ETHANOLAMINEPHOSPHOTRANSFERASE; 1.
DR PANTHER; PTHR10414:SF71; FI05338P; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 480 AA; 54121 MW; 0FA84923E14ABAED CRC64;
MRLFALVKGE ELPVGKSDVT NVATCTEMKK ATPSAVTVTE GRTIQIFLGS GFVARKRRKI
LMGLFETKYL SASQLKGFDS YKYSCVDTSP ISKYISHPFW NWLVTFYPRT WAPNVLTLLG
WSLVMACFLV ESVLDYDLTA NSVGSEQPIP DWFWMFAAIC TWLGYTLDGT DGKQARRIGA
SGPTGELCVF LLQILKSRFV FMLILSVDHG LDSWSTVPFT ITIFSVFGRG EYSVSPIHLL
SVLISVQIVF IVTHWEKYNT GILFLSWGYD ASQYTLVFVY LFTYFVGYKW YKFYVFGEVT
LAVVFEATFY FCCVGSLIMS AYNMWYSYAV ENTFKQLNAF QPSIYEASRP IIPSFILFAI
SLAWAVYSPT DVCGKDPRIF FFAMGTVFSN IACRLIIAQM SNHRCEVMNL LLAVYASSAG
FSFFMPSMEL IILRLMCLLV VVAHVHYGVC VVSPAIVRSF QNPCSGCFLL AKTTITKVTL
//
