ID W2TV90_NECAM Unreviewed; 339 AA.
AC W2TV90;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nucleoside transporter {ECO:0000313|EMBL:ETN84981.1};
GN ORFNames=NECAME_01543 {ECO:0000313|EMBL:ETN84981.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN84981.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; KI657838; ETN84981.1; -; Genomic_DNA.
DR RefSeq; XP_013307208.1; XM_013451754.1.
DR AlphaFoldDB; W2TV90; -.
DR EnsemblMetazoa; NECAME_01543; NECAME_01543; NECAME_01543.
DR GeneID; 25341585; -.
DR KEGG; nai:NECAME_01543; -.
DR CTD; 25341585; -.
DR OMA; RFYQYYS; -.
DR OrthoDB; 239997at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF80; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2, ISOFORM A; 1.
DR Pfam; PF01733; Nucleoside_tran; 2.
DR PRINTS; PR01130; DERENTRNSPRT.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 339 AA; 38341 MW; 7B9D66F77795DBB9 CRC64;
MKTFDENGTA HATEYSANFL NYLAIASQIP NLLLNFINIF VTVKGDLTKR ISLSLLIVGS
MIIFTMSFVY VDTWSWMGTF FAITLMSIVL LNGANGIYQN SIFGLASDFP FKFTNAVIIG
NNLCGTFVTI RFYQYYSKRA MQAGLTEGDV KKSGPSAQEY LDAFKQGWTQ MVNVYLVFFV
SLCVFPGIMV DVRDELVGQE YSFILPERFF VPITCFLLFN VFAFIGSMLA GRYQYPAPDK
LWMAVYPRLL FIPFFAFCNY RPLTRTWPVL FPSTWLYIFM GIIMSVSSGY LSGLSMMYAP
RIVEPSKGRM VSMMAGFFLI FGIVSGLAFT IVVSAFIEH
//
