ID W2WGM7_PHYPR Unreviewed; 1523 AA.
AC W2WGM7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=FYVE, RhoGEF and PH domain-containing protein 4 {ECO:0008006|Google:ProtNLM};
GN ORFNames=F441_14454 {ECO:0000313|EMBL:ETP09730.1};
OS Phytophthora parasitica CJ01A1.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317063 {ECO:0000313|EMBL:ETP09730.1, ECO:0000313|Proteomes:UP000018958};
RN [1] {ECO:0000313|EMBL:ETP09730.1, ECO:0000313|Proteomes:UP000018958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ01A1 {ECO:0000313|EMBL:ETP09730.1,
RC ECO:0000313|Proteomes:UP000018958};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ01A1.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP09730.1}.
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DR EMBL; ANIX01002836; ETP09730.1; -; Genomic_DNA.
DR EnsemblProtists; ETP09730; ETP09730; F441_14454.
DR Proteomes; UP000018958; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00821; PH; 1.
DR CDD; cd00160; RhoGEF; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00325; RhoGEF; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS50010; DH_2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 98..353
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 382..490
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 527..588
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 914..1176
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1201..1451
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..86
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1523 AA; 170087 MW; DEA3ABD8E8C2D3FD CRC64;
MSSQQQTVVE TSRAPRRRRG DAKPSRKKVT LRPGIVLFDP KDLVASSADD WTSSLDVELV
EDNQVDIEDD EEADNAEDNQ EENIDVDPDS PEAKQARLRA LVIEEICETE KSYVTDICTL
NDHYIVALED KTYRIMEDAQ IAVFFNNLRH LVMLNSKLLE DLEEIRQRRA GETKTEAAPK
SLSRTKSFKS VAEKRIGEAT KGLTRTSSFK SVAEKRIGEA TKGLTRTNSF KSSMPVAVQS
EAAGVGAIFC RYAPLFKLYG DYAKDYEEVA ALLQNFRRDT RLGFSQFLDS CREKSGSSKP
FESLLIMPIQ RIPRYKLLLE RLCELTPPEH PDASFLTEAV SRVRTVASGI NETVRRQENL
ETVLQAQQKF SGQLSLFTAD RRLLKSGKLI KMSTKRQEDV MIHLFNDILL YSNVLINGGY
RVRRIVHLQS KAVGVKTELP APVQALFDQQ AKRRKDCGFV VTSREKTFIL FTETPEAQRE
WVDAIASAVK EAQNQKKAGT GDEADGEGNN LESCEGPADA AALWVPDEMA ESCINCKASF
RAYYRRKHHC RRCGAVVCDT CSSGRAPLFV GESSRTERVC KPCFKVLDLV RQIAMHWLSR
VVEFRGVLRR RRFNKWSEHY YELRAGVLKQ FTVDTGAASA DQNGNVAGLT SSGSSGSALT
NSNTSRCCTD ELNLAGAIVI HRSDSRAHKN RFCFQISTTE YDETDPKNKA GANGANALKG
SPMQRRLSQI AVRQNRSKLS PLKLAVSRLN DAVSRRRESA LPPGVSAEGA MPLVSPPPLV
PAPSSSPTSS SSSNAAAMQE TEWILCATTI QEEVAWRVAI QSSADKALHR MRRSRVTDFP
GSLAQSGILS LSMSLPPTNV RASMSVITTG SFIGAPERRR LSSLDRGRAT DAELSMEMAQ
AAGDDREAFL LERRRRQILK EVIRSEESYV QCLGECIRLF VQPLLLRQLE GRQMYRRRQN
KRRGSMRPVL GTVNTSSGSA VPSRIRRRAG SSGNIGPAAA ANSASTQAPK MLVMDADLSI
FFSSVDQIYT LNQQLLDHLS RHLEETTTST QPPNAENGQK KGESPEFPGV RVHRAGAIFH
AYAPLMQLYT SYASRHSGAL TALDSPQFAG FLRELPPEAD VNRLRRYLNM PVERIPRYKM
LLQELLGSTP PEHVDYVPLQ SAISSVDRVA HKIEEISERR ENARTLATVS AKVGIDLSGR
HFVRDGMLRK VCRSKVQTYY FVLLEDAMVY GRQGGLHKKK FRLLDLWECK VAEDTEMMPG
VITTVVNSNN AFCFYSPLKS FILLTESEGE KKAWTTDISE CIDRNLRGKT HPRRASVRSE
VLTDNDDECS SGYELEGGFV IKNGWLNVSG GAAGSMSPSP TSSFSVGKKP RRLWITLSLQ
TISLGSTFKT AQPEETIPIE LCEVAPLQNE KCFRLQFLQD TKMRTQTTYV FEAQALVERD
EWVRALTHCI SGGDELDLRR RSLKTATLAP IFMFDKVSNV CTICTHSFAV YRPRHHCRYG
HMTHWQSLAC IRHMESSSRG AIC
//
