ID W2WW56_PHYPR Unreviewed; 1052 AA.
AC W2WW56;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Upf1 domain-containing protein {ECO:0000259|PROSITE:PS51997};
GN ORFNames=F441_10645 {ECO:0000313|EMBL:ETP14413.1};
OS Phytophthora parasitica CJ01A1.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317063 {ECO:0000313|EMBL:ETP14413.1, ECO:0000313|Proteomes:UP000018958};
RN [1] {ECO:0000313|EMBL:ETP14413.1, ECO:0000313|Proteomes:UP000018958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ01A1 {ECO:0000313|EMBL:ETP14413.1,
RC ECO:0000313|Proteomes:UP000018958};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ01A1.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP14413.1}.
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DR EMBL; ANIX01002129; ETP14413.1; -; Genomic_DNA.
DR AlphaFoldDB; W2WW56; -.
DR EnsemblProtists; ETP14413; ETP14413; F441_10645.
DR Proteomes; UP000018958; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 111..268
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 119..151
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 133..161
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 179..209
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 909..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 117245 MW; 63F01308671327D0 CRC64;
MSDSFGFNAY DDFLQTQPAQ SQSSQSFPLT QASQSQYAFV DPSDAGTSAD SFYDQYQAPV
GSGTSFFDQS ATADDVSSTF QSQLDDASLA GDFQSLTFDE TADEDALDYT ARELPKHACA
YCGLHDPASV VKCVATEKWF CNSRGNTSGS HIIQHLVRSK NKEVSLHPES PLGETVLECY
NCGCRNAFLL GFIPAKQDSV VVLLCRDPCL QMNALKDMSW DMSQWLPIID DRSFLPWLVK
FPSEHEQLRA RQITSTQIAK LEELWRDNPL ATVEDLDRPG IDDEPIKVLE VYDDGYQYQN
IFGPLVKMES DYDKKMKESQ TQEGVMVRWD TGLNKKRNAI FTCSRPDSDL RLVPGDEIRL
RLGPSASMLY GKDWEGTGHV LRLEESEVAL EMRSNNVPIE IADGYLVDFV WKSTSFDRMQ
AAMKTFAVDD TSLTGYLYHK ILGHDVGVQP LRIPRSVGTH FSAPGLPELN TWQMEAVKGV
LEQPLSLIQG PPGTGKTVTS ASIVFHMSKQ NMGQVLVTAP SNIAVDHLTM KISATGLRVV
RLAAKSREAV ASSVEHLSLH AMIKSLDSPD KADLRKLMQL KDDIGELSSQ DEKRFKSLKR
QAEREILQAA DVICTTCVGA GDPRLSNFRF RQVLIDEATQ ATEPECLIPI VQGAKHVVMV
GDHCQLGPVV MNKKAANAGL KQSLFDRLVL IDKKHRPFRL RVQYRMHPFL SEFPSNEFYE
GDLQNGVAAS ERQLSSVDFP WPNPNKPTFF YICLGAEEIS SSGTSYLNRT EASNVEKIVT
TFLKAGVMPS QIGVITPYEG QRAYVVSYMQ RNGPLRSQLY KDVEVASVDS FQGREKDLII
LSCVRSNENQ GIGFLSDKRR LNVALTRAKY GVILLGNPRV LAKQELWNKL LNHYRDNHLI
VEGPLNNLTP SHMQFPLQKH TRGPRREGNG FNRRGPAPPL DSRFDPRYEQ TGVPPIDPLS
TGLPPPAPQR GTRRGPSSYV PGSMGPLTQD GMTQSSMGMD GPFTQMAQTQ SFSQMSSDKF
AMSQDSFGYE HDFKSQNIPM SQDTRNPGSD FY
//
