ID W2XAP8_PHYPR Unreviewed; 3861 AA.
AC W2XAP8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETP19587.1};
GN ORFNames=F441_06494 {ECO:0000313|EMBL:ETP19587.1};
OS Phytophthora parasitica CJ01A1.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317063 {ECO:0000313|EMBL:ETP19587.1, ECO:0000313|Proteomes:UP000018958};
RN [1] {ECO:0000313|EMBL:ETP19587.1, ECO:0000313|Proteomes:UP000018958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ01A1 {ECO:0000313|EMBL:ETP19587.1,
RC ECO:0000313|Proteomes:UP000018958};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica CJ01A1.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP19587.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ANIX01001318; ETP19587.1; -; Genomic_DNA.
DR EnsemblProtists; ETP19587; ETP19587; F441_06494.
DR Proteomes; UP000018958; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022527}.
FT DOMAIN 3426..3763
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3829..3861
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3731..3769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3861 AA; 431861 MW; 1B16BF601EFACF9E CRC64;
MNVLKFADKR VTSDDIEPRA YVEKLFYDIK FSKATQTAKG QMMEVIGYLV GKFPKEVDEN
VPTLLSWIEN ELEKQFSSNS PEMMMVNGLL FALARLLECD VERYKRDGAL QKKIYSYLLT
VFATTVSGNL SRYQVTNSSE TFLARHAQIF QQEIGPNGYL WFSYMKFCCQ SENKTIKEHA
FTCSNAILQV LNKYLVEAKD DARKKCLNKI LKEILPTVSD SAANTSMTAF AVQCLGWLAS
SIYVYLGAKG YGKIEDKLKT FGESLLALDT KVTAWRWPLF SQYVQCIGQF VQERHGVPLD
EGYVKFLGDM LCHVMAAYPQ CLWKSKVVVH KSIAAVFAAL SNWTVIDPLV DRFVLHTLML
SISNITDSEV IIYHPDTGEL VTNLLYEYES FWLAMLGRCT EMAAEPTLVA MKTGSDDVEM
KEPSDVGRSL QTIIFDSTVK HVLGIIGQLN LSYQFDLQTT NNGKNATGYL PTVPRDHSIM
LNMTEFVERV LGQVLRPLLR PWIPLIMQRV MSSASKLPLV SSFYRIGTVV AIAMDDLKFF
DSPPIIDDRL SRFRDDFKTF VQRVCAQARF YQDELLLTCS EFVLTAPIEL IAVHTMIGIV
RSVLELGRSY LPAAIVAVTA LERWQKQCLN DLEDVISEVI PLLSAYLDQE ALSDEESSLV
KLSGKGMRNT SSNETSDLAQ LQRRILLLLG KCGGKISLLM SEPPSLINAD GSMGSISSPF
FRLELQLSEL SISLAMDPIL SHLGNLATHS SVRRVKASAS EGYHALVCYL CGKTATYPHA
AGKKSEFYDT WRGVFARIVR LATDPEKICR SLFEPLLFQL LRWMAANSDT FPFEYSSMLD
ELTRSLSDSE TAVRTMSARC IAVFLSLALE NSKAQANADD IFERVFSLCR HPGAVQRSGA
AASISYFLRS FKEEDGQILT QFALPCLKNL LYALRLCDND VRNRIGGVDI SRDVISKAVM
KIKRGICRFP QLFLKGSTSA RDVDEDSVLQ RTTLWLFQQT GAREVLFRRL CQQLFMSFST
LISKSSAEWI QKYASTHGSE SVVTVLVPMS SLAHTSITVQ WMEQLSASIE SYVWCVEMLG
DKAKDIFENS LTSRQESMKR KHFADVSAQE YSCQQTLSWA IATFLKNGGP WEDSLKGSHW
TGAYLSVLTS LCCCVMSFMK TGNVVLRNVA DMDTQSFRGA VAEKLLQAIL HLPDTQVHDA
NSLDGIEEFC SGVITRSPDW AQQMQETVDS MLSNLQLCLA NVNSSESFVE HSITIGLLSF
FGSKVLSAGI ISFPVADKYV EMFAMVASKA MEYGHGSPHD RLVAIAALKA AAACGWRITD
IFANPADRQV YGPVYSDVIH FMPTLAVWNR CASELVSQSL KNDFVVNVLA DILCQVTSFK
VYPSKSADWD VFTKTLVANV KQFVSNLEAV KADTQRVLST LQVLRHFLEL CQHCSESLVE
ALRMGPIPDI QDAIIKLLKQ RGCSYLVKAE VLRMFALLGP TSLLVSNEEQ ASKAMLDALV
ALVFDEFPIV SVDVARGSKE FDVFYLLFSE LLGVIERSNS IAYLKIIYPS LKEADNHLFR
TEIKQMLARF SISLGSQTGH ATSGERIRHQ LVELLDVLLD PTLDIAIRKT LLEEVFTPLV
ECQTGETLLQ FYLMESLTKK STIISLLATL VSTAAEVSSG GSRIGVFVAF SLVEILYRLI
DPEIIRTEIN SAFLGHKNGK GREFTMLVCK CASKVVTKTY GDVDDLVRLA CCAAYNCLLT
AVSRTQKQEK FFDQILFQPA LWSNILDLSR EYELHAETET FATIPLSSLS AISLEARLDT
NATTNAKSKR NESAALRFFT ASSLSMDTDS QTASTLTASL DVNQVGSTYE NIEIELDTFN
QHPCMIPLLR VLVQMKTDFG SSWSEKAMPG WMKKIFDVIV DPSTGLNVRL FVAKVVLNVP
NVFAMYSSPW LRAVMEALLD ASAAQKAPEF NYILRDCCNL VLNSWKDVAV SSLSDTASRF
VNELVKICPE LNNLIRNSNV LLITELIALW KDSASVDAGV LITYMINDDD DSKMKSAKQF
AALQIVSAML TTGLESELLV EEGGQTIEDG ILLVMTSKTT SLYTLAAEVG GLYLQTAGHS
EGEEFMCKVR NLIIGSYNEE NFGRFLALLR NASMHQPEII DSVMLQRLSF VLPKAVAVDA
WALLAADSLN NAAGNESVVK DIFTHAQSVL GRFVAHRHAG VQLSTLGAIS RLLDHLNLSE
LERLIANTSE GGIGTLKCYE GHDLSEYRRL LFTVGKKLYE KDLSDQVKSR VRVSLLHGLC
DSDDQRRKEA FEYWNTSAAI VNSCSDRLLS IFGSLYSSEF DEKWILYATN LLVGMSKESS
EFERPLFTSA LGSGEYAETP IDASWEAKTQ SMAPLFSVEA DLFSARPEFT QQSTSLTYTA
SQADGSLGST IQSQLFLSKP ASIGASYSQS FGESDVVQQR PGRNRFFKRR AAAVNSAVKD
PSSYDKKASK RFFQDQYALL KKKEEAQKTR ERKQRQGHVS MKRTYRVGEF PDIQITQQDI
VDPIMALCET SIETSSLVFG ALFSSIVASP QFEKSGITHE LTERLEETLT LSQSSSVYVG
CIVSAYFASI VRNPRLCEML PVRPKTVGEA GLSSGKYHIS ELTLEEQLLH EIQGKTRDLN
LASNELVTNC WDLLHKLLST MHKRNLLIAL SMACSTTAES KLALQAQLSG DLPLAIASYK
KAESILDSQM EILDGDNSFA TETDATRCRW QRRNCLETLN NWDTLKNELT DATQTDSDFL
WKQRPPYLEQ GVGHYLRSCL GLVEAKQTNS DLASLRSFIE GAMRDSAKME LVQSRFPVEM
CLTYLSSSDK NQARVCVETF YTNFLKMWRQ TSPMASTSRM QLLQSLSSMV EIDEVLSRFG
RDYSDIGKMG HQSVTAFMDA WRRSPPSTGE EGMVLWSQHS MVQNTVAGFM LNYARDQRLY
SDEIGLAVLG GKSNTMLQYA NAAISCNILA LASKMLKNYR ELCNTHQLPK LSVQMVEVFV
SHVLKLVDRQ EHQSDKSGSN SSSIKLITRY YETATKMFDN VEIMNMMETA GASDKVAMGY
LEAKTFASAA GFYAVNDVDD NLKEEYLSRS LDMFKVSCKR IDAVSRKEME DGASSAFLRC
RLTFIEFLND LFFKRKMEKL AKLTDRKALT KLLAENVLGG MAAGDRECAN YFPQLCDVIA
PYPDIVAEFE QCVLTNVPLW TCLQWSAQLM ALLNGPIGKT IVAILEKMAE KYPVALFYDF
MVTCRSSLGK FKVDLHRLEV LLSNTVMEKF VTALRLIHHP DFRLKEGLRE IAKLIEDNRM
SDARQKVEHI WKDCFSPDHP LLGTQIGRYN RDWSRKAKRD VEKIMGKDGS KMTAKTVNTA
REWIMNHFGV TPGRYGITKD MKAHLGDFAE WLEEFDHSSC ILELPGQYTS YWRPPDPSTH
IRILSFDSML GVLASKQLPK RLTMHCSDEK DYTFLVKGGE DLRLDQRIEQ LFGVMNQILE
ADPRCCDQRL SLTTYDVIPM TQEIGLLEWV GGTTTLKAVI EAQLQIDERC VDLKSNKRQK
LELFNTTAAK TYESFLLKQR GASFSAKVVA PRSKDVVDQF AKVQAMIPAD LLRRQLLGLG
SNFEAFLLVR DQFLKSVAVF SACSYVLGIG DRHLDNFLLD LASGRVIGID FGVSFGSGAS
VLPVPELIPF RYTRQMDFVF QPYDGANLLA QEMQAVFDAL RSKRQVVESV MNVFLHEPLL
DWQQSTTTRQ KALFESKGDD QSTLQDSDVE MEDVEEPRKT TSPAGGNETT AWLPDVKITI
ARRKLEGVSP ALLLKEELAQ NPHLKPHLSK FHVLVDTANI GEDGADEMVE LSSLTQAQEL
LAMATAPDLL GRTFQGWMPW L
//