ID W2YSW4_PHYPR Unreviewed; 693 AA.
AC W2YSW4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=F442_14244 {ECO:0000313|EMBL:ETP38066.1};
OS Phytophthora parasitica P10297.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP38066.1, ECO:0000313|Proteomes:UP000018948};
RN [1] {ECO:0000313|EMBL:ETP38066.1, ECO:0000313|Proteomes:UP000018948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P10297 {ECO:0000313|EMBL:ETP38066.1,
RC ECO:0000313|Proteomes:UP000018948};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P10297.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP38066.1}.
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DR EMBL; ANIY01002964; ETP38066.1; -; Genomic_DNA.
DR AlphaFoldDB; W2YSW4; -.
DR EnsemblProtists; ETP38066; ETP38066; F442_14244.
DR Proteomes; UP000018948; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR InterPro; IPR015914; Purple_acid_Pase_N.
DR InterPro; IPR025733; Purple_acid_PPase_C_dom.
DR PANTHER; PTHR45867:SF3; ACID PHOSPHATASE TYPE 7; 1.
DR PANTHER; PTHR45867; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|RuleBase:RU361203};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018948};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..349
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 364..583
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 603..660
FT /note="Iron/zinc purple acid phosphatase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 693 AA; 78380 MW; D84944151E487762 CRC64;
MPSSKNQVTE SFVKKTQHIN AYLSIEVEPC PEPPTSNLSA LDDSNRSRII SRLHLLLLLP
LLAVVIIGVA SSSTPLRTAE AVREQEPEDA HDYEKREVEN CVPYDIRSNI VGSLAVVEWS
TRRTYIPQVN LQKAGDDSPA LENPWRSCHD VADVEVRYRR LGANDTMLLI GDSNEPFTRK
VATTNTSDTA SFNAHSVRID LLEGEEDIAY EFTVGSAFHG WSAVHRLGFN VPYRGDEAER
CRPKHVHTAY GRTPGSLSVQ WMTKQFCAEG DTQLKLVEGY HAHIEVEGPK ATPVAAWANT
TLFEDEGEAQ SKRWMHVVRL EGLKPDTRYT YVVGNAHYSS WSIPYVTKTA PALLHPREKP
KPTRFLVTGD IGYQNAATLP MMQSEVAEGF VDGVVSIGDY AYDLDMMDGH VGDIFMQQIE
PFAASVPFMV CPGNHEHHNT FSHYSERFRL MPSNENEGVQ TVHIGGRSKE ARPKEVPNNW
FYSFDVGLVH FAVISTEIYF KKTFDVDGDV IARQEAWLEQ DLAKANANRE QTPWLVVIGH
RPMYCTSDST NCGDKAAMLR DRLEDKFFKH GVDVYLCGHQ HNYERAFDVY KSQTWKRTHN
MRATTHILTG ASGQYLTTIM RKAFERPAEP WDAFRNNVFG YSRMEVVNAT HLHWQQIEAD
PENPAARGHY GEIIDDVWLV QERHGSYETS AVS
//
