ID W2YYA4_PHYPR Unreviewed; 704 AA.
AC W2YYA4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN ORFNames=F442_12588 {ECO:0000313|EMBL:ETP40008.1};
OS Phytophthora parasitica P10297.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP40008.1, ECO:0000313|Proteomes:UP000018948};
RN [1] {ECO:0000313|EMBL:ETP40008.1, ECO:0000313|Proteomes:UP000018948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P10297 {ECO:0000313|EMBL:ETP40008.1,
RC ECO:0000313|Proteomes:UP000018948};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P10297.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP40008.1}.
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DR EMBL; ANIY01002604; ETP40008.1; -; Genomic_DNA.
DR AlphaFoldDB; W2YYA4; -.
DR EnsemblProtists; ETP40008; ETP40008; F442_12588.
DR Proteomes; UP000018948; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd06457; M3A_MIP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR033851; M3A_MIP.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804:SF79; MITOCHONDRIAL INTERMEDIATE PEPTIDASE; 1.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000018948};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 256..703
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 704 AA; 80030 MW; 53E080E930AEFFBF CRC64;
MLPLRSVVGR RQLTRHARLL SVAGTPGRPE GVSAAASVSS TAEPKPGLFQ LPDLHTPSDF
PRLTRDVKLQ CHQLRQELAA SSPGLETLRT LDDISNAICS VIDAAELCRN VHPNENFRRA
ASECFTELSD FIQNLNADVE LYRALKTVTE DKISMKSFTP EQRRMGILLR NEFERDGIHL
SRSDRQRVIS LQNDITQLSM QFQSTMYSAR DYVEVPAKLI RGMPHSITSV CERKWMSRDT
LRVPTDMHVM NTILKWVGDP EVRRKMYIAA NSCAKDNLPI LDKLRAKRHE LAQLLGFPTY
AHLATSDRMI GSPEAVESFI EDIAKQLMSK AKLEQQLLLD AKRKHEGRSV DHVYMWDLPY
YMGMLKAHKH RIDSRVISAY FPLENCLKGL HLLCSALFGL ELKQIPMLNA SERWHEDVVK
LALTRNGETL GYIYFDLYPR PNKYNHAAHF TIRCGKRMSE TTYQKPIVAL VCNFNKPAPD
SPSLLSHAEV ETLFHEFGHA MHSLLSRTEF QHLSGTRATL DFVETPSHLF EYFAWDYRVV
SEFAHHYRTG APLPAEMMQG LRASKTMFAA MDTQTQCLYS MLDLQLFGQQ PLPCIPPTTT
QMLHELQNSS TLVPHVDGTY WHTRFGHLIG YGAGYYSYLY ARVFAADIWH TNFLGSQGPL
NREAGDKLYQ KLMGHGGAKD PNDLLVDMLG REPSPVNYLH ELGV
//
