ID W2Z1X8_PHYPR Unreviewed; 5206 AA.
AC W2Z1X8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Dynein heavy chain linker domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=F442_11540 {ECO:0000313|EMBL:ETP41263.1};
OS Phytophthora parasitica P10297.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP41263.1, ECO:0000313|Proteomes:UP000018948};
RN [1] {ECO:0000313|EMBL:ETP41263.1, ECO:0000313|Proteomes:UP000018948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P10297 {ECO:0000313|EMBL:ETP41263.1,
RC ECO:0000313|Proteomes:UP000018948};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P10297.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP41263.1}.
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DR EMBL; ANIY01002400; ETP41263.1; -; Genomic_DNA.
DR EnsemblProtists; ETP41263; ETP41263; F442_11540.
DR Proteomes; UP000018948; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46454:SF17; DHC_N2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46454; DYNEIN AXONEMAL HEAVY CHAIN 7-RELATED; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018948}.
FT DOMAIN 1106..1537
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1687..2025
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 3034..3168
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3479..3666
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT REGION 764..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4965..4990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1051..1085
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3999..4072
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 772..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4972..4990
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5206 AA; 584371 MW; F10807A904DB02D0 CRC64;
MKPPMRPKSA NAVSRQVSRH RMQLVQDSAA VLSNNQQEDE SELMKQRDLE SVLMSNKEDA
LRSGVATAVK SSKRPFSAVS TPSFNRTGAK ISEESNRYAE MTTKFASAKA LSGVKRPHSA
AASTRYQPFR AREKSTSSLA SCLSVVSRAT NATRRMSASR SRPASSRADR LLASTRGHSD
NTFVYAVPRH FLEHGLPYDP YDIVPVTHEA LFGDGSISQM KDARWDYYTI SQSGYTFHLK
TDGFQSTFLS LRDWEGQKAN FTELRNLSTF SRFRYRKVFV AWRQWVQHNK REAAREHLLA
DCYFSYPVLL NGMEEIRMEL NSLSKLQLMW DFNGDTSSLE NFPTANVQFL KTRTKILRQI
TTRVQSILTK ICRVFLGDKA PLHAGFPGHE FALSVRKSSN YHILESYVQC EQGLASAHQQ
FLQHKHFRSS RFTTSEAAEA RSTLSSLPED AQTMRVLKPP RHSEELEDIR WTMASIKRRK
CKQLTKFVTL VDFLLLDAYS HVIKRSLDLF HAFILRGANA ATITRLTDHD DLALALHQTV
NVARQSISPS TEGSIDPSQP RQLAPLTRQQ IKAILHAAWK GKLGSNVTEE AVTVSIATME
NKLETLFFYG LSKKSGLNTD TFSVDDFYFV AENALIQLLV LPSFTASKTS IFTTENDANN
CETSTGNMPL VEREVLSIPC LHPKPLFTLD ASTSAIVEKR GRQRYQLCFK PELTVLVRVL
QDIITGFTEA FRDVPPLLSN PELRSVLAFA DDIRALNLYS SFGSSASSRS LNSTRHERDE
GNSVSDDDDR FRCPADRLLE RMEEDIQFLS IRDEIQELVR SALNGAEELA ASYSTILELR
QQNESVNFEL KARLFRRNEY TLEEMKDDAQ NFTNQLRALE ALRMSTNVEF LHFSMEQLQA
ELLPSPSRCL DAMRDLLPRL TRERCDQFLQ YITVSSSKIE KPITHDLDAF TTYLLNLRDV
YDEIHDRELD LAFLHEFFGV LDTLKFPAPV ETIKVFVLCD PEFHALKSHV LEACTNRDND
LQSYTALLNE NLAKLTRRTN ILQSSASDQA MAAQSNTCQD ARDNAVKLNK EAEQMQEEAR
RLVRIQRVFE ESSTGTRPPT KNYEDLHELA AELKLKSELW EVVCEADGHL STCSVDTIRS
VDLEKMNEVA SHIDLVVDKI RACATQVASG FELERLEKLQ ATLHGLAPVI RDLRNPHLVE
RHWSKLEHKM QCSLMPVIVE TTESTEDEEA DTSTSTSTRL DLQMQQLLDA NVVAHATAIR
HVSEEASAEA AIAGSFMSLV RTWEAQEIPL EPRKDRDGRD AYCIGDCNEL TSLIEESQVL
LRVMDLSTYS LVIQERLPKM ISDLNHTKES LELLLVCQRK WDYTQRLVSI DFARTFPEQA
KQLQKHDTSW RTLTLGLFNR PKCLPFGVST EHRQSLLVIL EGFEAAAKIL AEHLEIKRQV
FPVFFQLSDL ELATLLSKCR DVSCIQSFLY QCFDNVGRIV FGTRDGFQDI LQITSRVYGE
AEATPMGKNL KARGPVEQWL AAVEKRLAEQ LRRSTKHAIE ILSRYTDDSE ASNLDTSHFS
IQSILLADRI VRCTIIENGA KDIMNSSDER TINELSVYSA RVSQNLPSHD EDLSPREITL
RTCLRLQELQ YRDSFSSHMA AKESNSLSLT SGGLAVDWEY QLKYRMDDAT TVGHECHIEM
NTLKIPYGFN YLSPYNDVVV TPSSLRSLFS IFACIRHAQG CALTGPSESG KRTLSVQVSS
ILGRRYFSAT LTSYTHATRL LIGALYAGGT FCANLQLKRS IQDNALLIKT LATTLASIEH
AVLTKNQIIA VHRSPINFIP GTAMFVIFPS NLVMKDAEEI RIWTENLSQF AIVQWDRDYI
VEALLMSRGY TGPRHLAKQL LVLWQHARST LDLSIRNPPG YETPFSFTAL KTVINDGGSK
LKLKQADQEG SIRAAVLGYF SVRMDDIQLK ALENIVKNSL PLSNETILQP RSGIRPELQE
AISGAVRELH FIPRQATLDS VSALATALTF SVSTVLVGPS GVGKTTTYQV LAKAFELSLQ
RQDEGAPAPS NDDTLTVTNT LTPPVKHFKS PSVSIHVVLP MALTVSQLYG GVSLDDHGRM
PSILGQLIRE AQERYTGHRD STPESLLDFD HQVWVIFDDA LDLRWLEVLL AVLVKSRASL
SPLLAFEDGE FMTLPPNLRF IFEILQLRDA TPSFLHVTSI LHLTGYSLTD AQESEPFSLV
GDQSKMDISI AYLYRYLVLE RERIAQSDAS KSQTWSSTDT FNVIEKWLMH SSLLGELAAV
IDGGAAEMVN LPPLQRVTNL VSLLQSLVST ASALSDPKLS SYPEFSDTIS TGQIRVEMAL
IYSLMWGFAA CTDTVIKRQV SDLLIRQFEH LKPAWISCGT HINLYETVLD LQGLRFVSVV
NSTGPVALPP PATTCNNISS LFIPTSSSLV IHAALREALR SGRGVLLIGA DSARRTTLAR
NFLSQFEVIR SIISAGGVSN MLQADKDNDK TRKPALSKSI EAATLASVKR LRLRQISLVT
VMAMRLQKEK NESDESTAND RSIVEEEEGI PLTITPSLDP VKTAMVRQFD RGDVIPFFFA
MPHGNADTVT ELSNCLERML QRERSGVFEP PPGKAALLIL DDLHLATPTE ECTLKQANPS
VYAYLRSIQE QRKVYRGSNC LPISVENLML LASINCEKFQ NFTIQGEDSA QKITTQFFPV
LAPSCELEEL HNIFNQALQT HWSLSTTSVT LSPAVRYAIP TIVAATTVLW DRLRRAYKFC
LHDLARVYEG LAVVVPSVIS DVETLIRLWT HESCRTLREP SMGLCSSQQD SEIATEIVRM
RSIVSQVTQR RASVRASLAI GPGSGLGFAK RQSIQVSPEN EENASPATLL ALFTARISAP
SGKRLSRPSL QFNSLQEQQH RAVIMGGLWA FVPASIYYGG APASLGQLGE NNVTNSGEKR
LSTRALRRSS ASFMRRKSLE TVVDGSSSHV GRSGNWIYAE ISFEDDNEAV STAAMQAYFR
DLRTFSSTLR SLDAKKTTAL PRDVPYVPFK LALSVVRIDR VLARPAARLV LLDNNCSGAD
TLLRYATTSR TPEGHEDSAI LTLSGLQDDP NITTNVNFCL MTRWKRLLLD LYERVGVCGQ
EATLVIKRLD LLPTTIVNQI QVLMTTGEVP GILSLEEQVN LATRVCDERL LALKTQHAAK
VAQIRAEAEA TRDQALAVLH QKQREAPSTP MLEAFQQVET RYQRELRSKL ARVDLRYQQD
SDDLRRQREV ESESVAATVM ALTRPLGVTS GKWASAVARM CSKLRVVLLV DQEHEKFVRA
ACPSIFSTCD IVSVPQLDRD SLRTIVYAHF HAQILDQISK NDGILADTLH QVHRSLWSVA
CMATDMHLAV ANMFKCEFPP TSRIFAMAEF FSRLFIENFK REEAFRAKTA WFLDLSNRLD
RDLGALRSSD KLLTEQLSTI DQQLINDEVK LTEQKQDAER IRLIMERFRT AADEQILVTT
EAQEQAQKEL REPMVCLEEA NRALLLVDRR HIVEIKSFVS PPPLVQLVLG AVCVLFQLES
SWESARRLLL GDANFVQNLL QFNKDAVSAA TLSKLETEYL NDERFRRDEV ERQSVAAASM
VVWVRAIHQY ATSRQKVQPT LDTLEKAQGR LQLIMKEFQV SKDRVVQADA AWQATQAGID
TANTKKEALK SEITSLSARC DSGDRAMEAL KEDRKLQNEA ASAISMRRGF SLTTWNTLLS
AGALAYACEL SVSSQRDRVF QAWEQAYCVY GGLTPGCPPT STCCTFIPSI IVVLKETEPQ
SGELETPLTS LFSGEYTPDG SEMEETTKLV TSVGDLGFSR RRLWDAWLLS LVVFTSSVPV
AMITRFSYEM EELLITCARR VWHWNQLYMV YARAADFDDV FKVAARSGHQ LLVLDVEPID
CESREENNYL QAALNWNVKC IDGTAHLVLN KKLPEDEASN TDTIALHPNF RLILTSHASR
AAFGELLDIL PTLDGNLHSS DVHDIMLDKI SLETEKFTLK TALKEHAQLA QQYEAAQNQL
TKLLEAAAVT SQFPLSQTKA LRERVTAIHE ARQILRDKRR EIQEQLRLVK LQCTPMARTG
VAVFNAFNAT ISGNTSPPLT LQVILPILLD SVSTILSKTN ATTGVPITPD VKKSSASRRF
GILARTAATF AMSSRGQSNS TGVLSEVLTS LLGRIAPLIP NRDWYCFILQ LVRNLEETPS
PKEASVPKER RNRFENEVTI SRSVDTILLQ AKLKRGLNDT TSCLITAETC KTVALSSSRA
DFQRRIVSTI LNGSKGEHIL PDAQDVNSIV HLAIPEDASK SERLRGVLVL FPYLVQHVCD
RMLASYGVSL NVQQRGSVET EKGFWLRTLR KLPEKTAVVV RTRHEFNSFI FARRVFFQGL
NGSTSLQLRV LQILVERKFR TGKQDKSANL TPLSELYTFP RSVDTEDEEH VKQLLLVLND
FKQILEMEKT ELEALEEAPL AIINMKDKSG TAQNWEELFQ ILNRASARTS STTFQRYNSV
DTVPKETVKR PSVVKEHSMT GHRVSTCQSM MTRISAKDLV TPTYPRLVAA VDEWTSLPIH
LRSSIVCFRD EYEEESCASV SLSKCLQSTI LRLSMYPSVQ TLYSLVQAED NTVRIPVTPI
WQVLAGLVLF HATLVFRANV LRSAYPDFKA VFYYYDDDFL TAVNQYLATV LEKKQHYSPQ
RRRTGKTTDY SAVLERRIYQ QVVLSSYTRI MNGHQEAELL KRLFAECLQL VSWNPSSERE
RMGSLSSIRG RSRQMSVREQ IRSPELTPST HSPSMPLIKG ISTLSVVNSS LRLGFLVFPS
EALQTPDLSM NQWLELVWSY SASIDKNKDS KLQALLLGYQ QSSTRRGSLE DTTRDLFATP
QDAEMAKLLE PKWMKAFGWI NENRIAVLSD AEMISTMLLR DAIEIIRAII DEAVPPRLDS
DQEASDLIEA RTAMAICSVY NQHVEGCLVT LETILSSLQA AVPVDTPEQD DSLVEHSEDE
DDDDDDDVEQ EEGNLLHLAH IKDTHVRQQI VAILRSEIPP DLFSHGTLPP PISSTWSLHD
VLQHYRDWHN FLISSNLNVT PSRWWLPGIL AARLPLTYIL DIAQPSDKSM LFTLRLLSDE
SEREPPETPT APIPANAIAI IDGIVLLGAK WNETLQSLEQ GNDLQQQQRV QLVCFLSTNT
SSIIQRVPLF ASHDGTLLLE CALPVDQNGL NPLATPFMVP LGPHYR
//