ID   W3AMQ0_9FIRM            Unreviewed;       366 AA.
AC   W3AMQ0;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Pyridoxal phosphate biosynthesis protein {ECO:0000313|EMBL:ETP72301.1};
GN   ORFNames=UYO_1739 {ECO:0000313|EMBL:ETP72301.1};
OS   Lachnospiraceae bacterium JC7.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1165092 {ECO:0000313|EMBL:ETP72301.1, ECO:0000313|Proteomes:UP000018967};
RN   [1] {ECO:0000313|EMBL:ETP72301.1, ECO:0000313|Proteomes:UP000018967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC7 {ECO:0000313|EMBL:ETP72301.1,
RC   ECO:0000313|Proteomes:UP000018967};
RA   Rosewarne C.P., Cheung J.L., Evans P.N., Tomkins N.W., Denman S.E.,
RA   O Cuiv P., Morrison M.;
RT   "Isolation and genomic characterisation of Lachnospiraceae sp. JC7, a newly
RT   identified member of the bovine rumen core microbiota.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the PdxA family. PdxA2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00009464}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETP72301.1}.
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DR   EMBL; ALYD01000017; ETP72301.1; -; Genomic_DNA.
DR   AlphaFoldDB; W3AMQ0; -.
DR   PATRIC; fig|1165092.3.peg.1721; -.
DR   OrthoDB; 9801783at2; -.
DR   Proteomes; UP000018967; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR005255; PdxA_fam.
DR   PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR   Pfam; PF04166; PdxA; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
SQ   SEQUENCE   366 AA;  39912 MW;  882201B69A924DCC CRC64;
     MADNRPIVGI SMGDPFGNGP EISVKSLNDK TLYDRCKPLI VGDKTSMEYA LKVAKKVDGI
     DLKLNIVKEP EEGKYEYGTI DLIDLGLVKT EDIPDSLNNE KGPQPFGIGA CALGGEAAFQ
     YVVYVIKLAL EDKVDATVTN ALSKEAINMA GHHYSGHTEI YADYTKTKKY AMMLAHEELR
     VVHVSTHVSL REACDRVKKD RVLDCIHMAN EACKALGIKE PKIGVAGLNP HCGEDGMFGR
     EEIEEIQPAI DEALKEGIII PEKKPTPPDT VFSKALGGWY DIVVVMYHDQ GHIPLKVKGF
     VYNKEEKHWE AVAGINMTLG LPIVRVSVDH GTGFGHAGNG GANELSLVNA IDAALQMASY
     RKSLKA
//